Cutting edge: conventional CD8 alpha+ dendritic cells are generally involved in priming CTL immunity to viruses
Dendritic cells (DCs) play a central role in initiating immune responses. Despite this, there is little understanding how different DC subsets contribute to immunity to different pathogens. CD8alpha(+) DC have been shown to prime immunity to HSV. Whether this very limited capacity of a single DC sub...
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| Veröffentlicht in: | The Journal of immunology (1950) 2004-02, Vol.172 (4), p.1996-2000 |
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| container_end_page | 2000 |
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| container_issue | 4 |
| container_start_page | 1996 |
| container_title | The Journal of immunology (1950) |
| container_volume | 172 |
| creator | Belz, Gabrielle T Smith, Christopher M Eichner, Daniel Shortman, Ken Karupiah, Guna Carbone, Francis R Heath, William R |
| description | Dendritic cells (DCs) play a central role in initiating immune responses. Despite this, there is little understanding how different DC subsets contribute to immunity to different pathogens. CD8alpha(+) DC have been shown to prime immunity to HSV. Whether this very limited capacity of a single DC subset priming CTL immunity is restricted to HSV infection or is a more general property of anti-viral immunity was examined. Here, we show that the CD8alpha(+) DCs are the principal DC subset that initiates CTL immunity to s.c. infection by influenza virus, HSV, and vaccinia virus. This same subset also dominated immunity after i.v. infection with all three viruses, suggesting a similar involvement in other routes of infection. These data highlight the general role played by CD8alpha(+) DCs in CTL priming to viral infection and raises the possibility that this DC subset is specialized for viral immunity. |
| doi_str_mv | 10.4049/jimmunol.172.4.1996 |
| format | Article |
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Smith, Christopher M ; Eichner, Daniel ; Shortman, Ken ; Karupiah, Guna ; Carbone, Francis R ; Heath, William R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c346t-cee3675b83f908f62fed97aee5f5c25d4f4f86c38625c9ce51f76596ff1af2283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>CD8 Antigens - biosynthesis</topic><topic>Cell Division - immunology</topic><topic>Cell Separation</topic><topic>Dendritic Cells - immunology</topic><topic>Dendritic Cells - metabolism</topic><topic>Dendritic Cells - virology</topic><topic>Herpes Simplex - immunology</topic><topic>Immunity, Cellular</topic><topic>Injections, Intravenous</topic><topic>Injections, Subcutaneous</topic><topic>Interphase - immunology</topic><topic>Lymph Nodes - cytology</topic><topic>Lymph Nodes - immunology</topic><topic>Lymph Nodes - virology</topic><topic>Lymphocyte Activation - immunology</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Transgenic</topic><topic>Orthomyxoviridae Infections - immunology</topic><topic>Spleen - cytology</topic><topic>Spleen - immunology</topic><topic>Spleen - virology</topic><topic>T-Lymphocytes, Cytotoxic - immunology</topic><topic>T-Lymphocytes, Cytotoxic - virology</topic><topic>Vaccinia - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Belz, Gabrielle T</creatorcontrib><creatorcontrib>Smith, Christopher M</creatorcontrib><creatorcontrib>Eichner, Daniel</creatorcontrib><creatorcontrib>Shortman, Ken</creatorcontrib><creatorcontrib>Karupiah, Guna</creatorcontrib><creatorcontrib>Carbone, Francis R</creatorcontrib><creatorcontrib>Heath, William R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Belz, Gabrielle T</au><au>Smith, Christopher M</au><au>Eichner, Daniel</au><au>Shortman, Ken</au><au>Karupiah, Guna</au><au>Carbone, Francis R</au><au>Heath, William R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cutting edge: conventional CD8 alpha+ dendritic cells are generally involved in priming CTL immunity to viruses</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>2004-02-15</date><risdate>2004</risdate><volume>172</volume><issue>4</issue><spage>1996</spage><epage>2000</epage><pages>1996-2000</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><abstract>Dendritic cells (DCs) play a central role in initiating immune responses. 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| ispartof | The Journal of immunology (1950), 2004-02, Vol.172 (4), p.1996-2000 |
| issn | 0022-1767 1550-6606 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals CD8 Antigens - biosynthesis Cell Division - immunology Cell Separation Dendritic Cells - immunology Dendritic Cells - metabolism Dendritic Cells - virology Herpes Simplex - immunology Immunity, Cellular Injections, Intravenous Injections, Subcutaneous Interphase - immunology Lymph Nodes - cytology Lymph Nodes - immunology Lymph Nodes - virology Lymphocyte Activation - immunology Mice Mice, Inbred C57BL Mice, Transgenic Orthomyxoviridae Infections - immunology Spleen - cytology Spleen - immunology Spleen - virology T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - virology Vaccinia - immunology |
| title | Cutting edge: conventional CD8 alpha+ dendritic cells are generally involved in priming CTL immunity to viruses |
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