Toll-like receptor-4 Asp299Gly polymorphism does not influence progression of atherosclerosis in patients with familial hypercholesterolaemia

Background Toll‐like receptor‐4 (TLR4) is a major receptor for inflammatory stimuli potentially involved in the pathogenesis of atherosclerosis, such as lipopolysaccharide (LPS) and heat‐shock proteins. The Asp299Gly polymorphism of the TLR4 gene has been associated with a reduced intima‐media thic...

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Veröffentlicht in:	European journal of clinical investigation 2004-02, Vol.34 (2), p.94-99
Hauptverfasser:	Netea, M. G., Hijmans, A., Van Wissen, S., Smilde, T. J., Trip, M. D., Kullberg, B. J., De Boo, T., Van der Meer, J. W. M., Kastelein, J. J. P., Stalenhorf, A. F. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Atherosclerosis Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels C-reactive protein Cardiology. Vascular system Carotid Artery Diseases - etiology Carotid Artery Diseases - genetics Cohort Studies cytokines Disease Progression Disorders of blood lipids. Hyperlipoproteinemia familial hypercholesterolaemia Female General aspects Genetic Predisposition to Disease Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Hyperlipoproteinemia Type II - complications Hyperlipoproteinemia Type II - drug therapy Hyperlipoproteinemia Type II - genetics inflammation Inflammation Mediators - blood Male Medical sciences Membrane Glycoproteins - genetics Metabolic diseases Middle Aged Polymorphism, Genetic Receptors, Cell Surface - genetics Toll-Like Receptor 4 Toll-Like Receptors
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