Modification of phagocytosis and cytokine production in peritoneal and splenic murine cells by erythromycin A, azithromycin and josamycin
Objectives: The aim of this study was to determine whether pre-incubation of peritoneal or splenic cells with different doses of the macrolides erythromycin A (14-membered ring), azithromycin (15-membered ring) and josamycin (16-membered ring) affects their phagocytic activity or cytokine production...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 2004-02, Vol.53 (2), p.367-370 |
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| container_title | Journal of antimicrobial chemotherapy |
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| creator | Ortega, Elena Escobar, M. Antonia Gaforio, José Juan Algarra, Ignacio Alvarez de Cienfuegos, Gerardo |
| description | Objectives: The aim of this study was to determine whether pre-incubation of peritoneal or splenic cells with different doses of the macrolides erythromycin A (14-membered ring), azithromycin (15-membered ring) and josamycin (16-membered ring) affects their phagocytic activity or cytokine production. Methods: Peritoneal and splenic cells from BALB/c mice were pre-incubated with different concentrations of these antibiotics, those similar to serum levels attained with the treatment schedules used in human therapy. Results: From our observations of phagocytic activity and IL-12 production by peritoneal cells, these macrolide antibiotics seem to act mainly as immunosuppressive agents, although they induce peritoneal cells to increase IL-18 production and splenic cells IL-4 production. Conclusions: Macrolide antibiotics can interfere with the Th1 cell-amplifying activity of IL-18 in conjunction with IL-12 and, in contrast, may induce a Th2 cell response in an IL-4-dependent manner. These results could improve their therapeutic use especially in immunosuppressed patients. |
| doi_str_mv | 10.1093/jac/dkh069 |
| format | Article |
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Antonia ; Gaforio, José Juan ; Algarra, Ignacio ; Alvarez de Cienfuegos, Gerardo</creator><creatorcontrib>Ortega, Elena ; Escobar, M. Antonia ; Gaforio, José Juan ; Algarra, Ignacio ; Alvarez de Cienfuegos, Gerardo</creatorcontrib><description>Objectives: The aim of this study was to determine whether pre-incubation of peritoneal or splenic cells with different doses of the macrolides erythromycin A (14-membered ring), azithromycin (15-membered ring) and josamycin (16-membered ring) affects their phagocytic activity or cytokine production. Methods: Peritoneal and splenic cells from BALB/c mice were pre-incubated with different concentrations of these antibiotics, those similar to serum levels attained with the treatment schedules used in human therapy. Results: From our observations of phagocytic activity and IL-12 production by peritoneal cells, these macrolide antibiotics seem to act mainly as immunosuppressive agents, although they induce peritoneal cells to increase IL-18 production and splenic cells IL-4 production. Conclusions: Macrolide antibiotics can interfere with the Th1 cell-amplifying activity of IL-18 in conjunction with IL-12 and, in contrast, may induce a Th2 cell response in an IL-4-dependent manner. These results could improve their therapeutic use especially in immunosuppressed patients.</description><identifier>ISSN: 0305-7453</identifier><identifier>ISSN: 1460-2091</identifier><identifier>EISSN: 1460-2091</identifier><identifier>DOI: 10.1093/jac/dkh069</identifier><identifier>PMID: 14729765</identifier><identifier>CODEN: JACHDX</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Animals ; Anti-Bacterial Agents - pharmacology ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Azithromycin - pharmacology ; Biological and medical sciences ; Candida albicans - immunology ; Cytokines - biosynthesis ; Enzyme-Linked Immunosorbent Assay ; Erythromycin - pharmacology ; IL-12 ; IL-18 ; IL-4 ; immunomodulation ; In Vitro Techniques ; Interleukin-12 - biosynthesis ; Interleukin-18 - biosynthesis ; Interleukin-4 - biosynthesis ; Josamycin - pharmacology ; macrolide antibiotics ; Macrophages, Peritoneal - drug effects ; Macrophages, Peritoneal - metabolism ; Male ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Phagocytosis - drug effects ; Pharmacology. Drug treatments ; Spleen - cytology ; Spleen - drug effects ; Spleen - metabolism</subject><ispartof>Journal of antimicrobial chemotherapy, 2004-02, Vol.53 (2), p.367-370</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Feb 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-c41ed6593a13ef29581e766aad3d1ebe4f176f91eb3a68409adf9d7d9916069b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15485775$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14729765$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ortega, Elena</creatorcontrib><creatorcontrib>Escobar, M. Antonia</creatorcontrib><creatorcontrib>Gaforio, José Juan</creatorcontrib><creatorcontrib>Algarra, Ignacio</creatorcontrib><creatorcontrib>Alvarez de Cienfuegos, Gerardo</creatorcontrib><title>Modification of phagocytosis and cytokine production in peritoneal and splenic murine cells by erythromycin A, azithromycin and josamycin</title><title>Journal of antimicrobial chemotherapy</title><addtitle>J. Antimicrob. Chemother</addtitle><description>Objectives: The aim of this study was to determine whether pre-incubation of peritoneal or splenic cells with different doses of the macrolides erythromycin A (14-membered ring), azithromycin (15-membered ring) and josamycin (16-membered ring) affects their phagocytic activity or cytokine production. Methods: Peritoneal and splenic cells from BALB/c mice were pre-incubated with different concentrations of these antibiotics, those similar to serum levels attained with the treatment schedules used in human therapy. Results: From our observations of phagocytic activity and IL-12 production by peritoneal cells, these macrolide antibiotics seem to act mainly as immunosuppressive agents, although they induce peritoneal cells to increase IL-18 production and splenic cells IL-4 production. Conclusions: Macrolide antibiotics can interfere with the Th1 cell-amplifying activity of IL-18 in conjunction with IL-12 and, in contrast, may induce a Th2 cell response in an IL-4-dependent manner. These results could improve their therapeutic use especially in immunosuppressed patients.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Azithromycin - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Candida albicans - immunology</subject><subject>Cytokines - biosynthesis</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Erythromycin - pharmacology</subject><subject>IL-12</subject><subject>IL-18</subject><subject>IL-4</subject><subject>immunomodulation</subject><subject>In Vitro Techniques</subject><subject>Interleukin-12 - biosynthesis</subject><subject>Interleukin-18 - biosynthesis</subject><subject>Interleukin-4 - biosynthesis</subject><subject>Josamycin - pharmacology</subject><subject>macrolide antibiotics</subject><subject>Macrophages, Peritoneal - drug effects</subject><subject>Macrophages, Peritoneal - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Phagocytosis - drug effects</subject><subject>Pharmacology. 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| ispartof | Journal of antimicrobial chemotherapy, 2004-02, Vol.53 (2), p.367-370 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Anti-Bacterial Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Azithromycin - pharmacology Biological and medical sciences Candida albicans - immunology Cytokines - biosynthesis Enzyme-Linked Immunosorbent Assay Erythromycin - pharmacology IL-12 IL-18 IL-4 immunomodulation In Vitro Techniques Interleukin-12 - biosynthesis Interleukin-18 - biosynthesis Interleukin-4 - biosynthesis Josamycin - pharmacology macrolide antibiotics Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - metabolism Male Medical sciences Mice Mice, Inbred BALB C Phagocytosis - drug effects Pharmacology. Drug treatments Spleen - cytology Spleen - drug effects Spleen - metabolism |
| title | Modification of phagocytosis and cytokine production in peritoneal and splenic murine cells by erythromycin A, azithromycin and josamycin |
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