The sodium/calcium exchanger family-SLC8
The Na(+)/Ca(2+) exchanger gene family encompasses three distinct proteins, NCX1, NCX2, and NCX3, which mediate cellular Ca(2+) efflux and thus contribute to intracellular Ca(2+) homeostasis. NCX1 is expressed ubiquitously while NCX2 and NCX3 are limited to brain and skeletal muscle. NCX1 exchanges...
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| Veröffentlicht in: | Pflügers Archiv 2004-02, Vol.447 (5), p.543-548 |
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| creator | Quednau, Beate D Nicoll, Debora A Philipson, Kenneth D |
| description | The Na(+)/Ca(2+) exchanger gene family encompasses three distinct proteins, NCX1, NCX2, and NCX3, which mediate cellular Ca(2+) efflux and thus contribute to intracellular Ca(2+) homeostasis. NCX1 is expressed ubiquitously while NCX2 and NCX3 are limited to brain and skeletal muscle. NCX1 exchanges 3 extracellular Na(+) for 1 intracellular Ca(2+). In addition to transporting Na(+) and Ca(2+), NCX1 activity is also regulated by these cations. NCX1 is especially important in regulating cardiac contractility. |
| doi_str_mv | 10.1007/s00424-003-1065-4 |
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| fulltext | fulltext |
| identifier | ISSN: 0031-6768 |
| ispartof | Pflügers Archiv, 2004-02, Vol.447 (5), p.543-548 |
| issn | 0031-6768 1432-2013 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Biological Transport - physiology Calcium - metabolism Humans Multigene Family - physiology Myocardium - metabolism Sodium - metabolism Sodium-Calcium Exchanger - chemistry Sodium-Calcium Exchanger - physiology |
| title | The sodium/calcium exchanger family-SLC8 |
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