Long‐term up‐regulation of eNOS and improvement of endothelial function by inhibition of the ubiquitin–proteasome pathway

The ubiquitin‐proteasome system is the major pathway for intracellular protein degradation in eukaryotic cells. Endothelial nitric oxide synthase (eNOS) is the key enzyme of vascular homeostasis involved in the pathophysiology of several cardiovascular diseases. The aim of our study was to investiga...

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Veröffentlicht in:	The FASEB journal 2004-02, Vol.18 (2), p.272-279
Hauptverfasser:	Stangl, Verena, Lorenz, Mario, Meiners, Silke, Ludwig, Antje, Bartsch, Cornelia, Moobed, Minoo, Vietzke, Angelika, Kinkel, Hans‐Tilmann, Baumann, Gert, Stangl, Karl
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cattle Cysteine Endopeptidases - metabolism endothelium Endothelium, Vascular - drug effects Endothelium, Vascular - enzymology Endothelium, Vascular - physiology Enzyme Induction - drug effects inhibitors Leupeptins - pharmacology Male Multienzyme Complexes - antagonists & inhibitors Multienzyme Complexes - metabolism nitric oxide synthase Nitric Oxide Synthase - genetics Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type III proteasome Proteasome Endopeptidase Complex Pulmonary Artery Rats Rats, Wistar RNA, Messenger - genetics RNA, Messenger - metabolism Time Factors Ubiquitin - antagonists & inhibitors Ubiquitin - metabolism Vasodilation
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