Methamphetamine induces neuronal apoptosis via cross‐talks between endoplasmic reticulum and mitochondria‐dependent death cascades

Methamphetamine (METH) is an illicit drug that causes neurodegenerative effects in humans. In rodents, METH induces apoptosis of striatal glutamic acid decarboxylase (GAD) ‐containing neurons. This paper provides evidence that METH‐induced cell death occurs consequent to interactions of ER stress an...

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Veröffentlicht in:	The FASEB journal 2004-02, Vol.18 (2), p.238-251
Hauptverfasser:	Jayanthi, Subramaniam, Deng, Xiaolin, H. Noailles, Pierre‐Antoine, Ladenheim, Bruce, Lud Cadet, Jean
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects apoptosis‐inducing BiP/GRP78 Calpain - metabolism Carrier Proteins - genetics Caspases - metabolism CHOP DNA fragmentation Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - metabolism Enzyme Activation - drug effects factor gamma-Aminobutyric Acid - pharmacology Heat-Shock Proteins Male Methamphetamine - pharmacology Mice Mitochondria - drug effects Mitochondria - metabolism Models, Biological Molecular Chaperones - genetics Neostriatum - cytology Neurons - cytology Neurons - drug effects Neurons - enzymology Neurons - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction - drug effects transcription factor
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