Risk of Vaccinia Transfer to the Hands of Vaccinated Persons after Smallpox Immunization
Transmission of vaccinia virus after smallpox vaccination is a concern. We conducted a prospective examination of the protection afforded by vaccination-site bandages in recently vaccinated individuals. After smallpox vaccination, inoculation sites were covered with 2 occlusive dressings. Site asses...
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| Veröffentlicht in: | Clinical infectious diseases 2004-02, Vol.38 (4), p.536-541 |
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| creator | Talbot, Thomas R. Ziel, Ellis Doersam, Jennifer K. LaFleur, Bonnie Tollefson, Sharon Edwards, Kathryn M. |
| description | Transmission of vaccinia virus after smallpox vaccination is a concern. We conducted a prospective examination of the protection afforded by vaccination-site bandages in recently vaccinated individuals. After smallpox vaccination, inoculation sites were covered with 2 occlusive dressings. Site assessment and bandage changes occurred every 3-5 days until the site was healed. At each visit, specimens from the vaccination site, outer dressing surface, and contralateral hand were obtained for vaccinia culture. For 148 vaccinated subjects, vaccinia was detected from vaccination lesions of every subject on several occasions. Only 6 (0.65%) of 918 dressing (95% CI, 0.24%-1.4%) and 2 (0.22%) of 926 hand (95% CI, 0.03%-0.78%) specimens tested positive for vaccinia. The mean number of bandage changes was 9.6 (95% CI, 9.17-10.0). Vaccinia autoinoculation did not occur. The rate of vaccinia recovery outside occlusive bandages covering smallpox vaccination sites was remarkably low, suggesting excellent protection against inadvertent transmission. |
| doi_str_mv | 10.1086/381205 |
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We conducted a prospective examination of the protection afforded by vaccination-site bandages in recently vaccinated individuals. After smallpox vaccination, inoculation sites were covered with 2 occlusive dressings. Site assessment and bandage changes occurred every 3-5 days until the site was healed. At each visit, specimens from the vaccination site, outer dressing surface, and contralateral hand were obtained for vaccinia culture. For 148 vaccinated subjects, vaccinia was detected from vaccination lesions of every subject on several occasions. Only 6 (0.65%) of 918 dressing (95% CI, 0.24%-1.4%) and 2 (0.22%) of 926 hand (95% CI, 0.03%-0.78%) specimens tested positive for vaccinia. The mean number of bandage changes was 9.6 (95% CI, 9.17-10.0). Vaccinia autoinoculation did not occur. The rate of vaccinia recovery outside occlusive bandages covering smallpox vaccination sites was remarkably low, suggesting excellent protection against inadvertent transmission.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1086/381205</identifier><identifier>PMID: 14765347</identifier><identifier>CODEN: CIDIEL</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; Biological and medical sciences ; Disease transmission ; Female ; Hand - virology ; Human viral diseases ; Humans ; Infectious diseases ; Lesions ; Major Articles ; Male ; Medical sciences ; Occlusive Dressings ; Risk Factors ; Smallpox ; Smallpox - prevention & control ; Smallpox Vaccine - administration & dosage ; Smallpox Vaccine - adverse effects ; Smallpox, monkey pox, tanapox ; Specimens ; Surveillance ; Tropical viral diseases ; Vaccination ; Vaccination - adverse effects ; Vaccinia ; Vaccinia - transmission ; Vaccinia virus ; Viral diseases ; Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye ; Wound dressings</subject><ispartof>Clinical infectious diseases, 2004-02, Vol.38 (4), p.536-541</ispartof><rights>Copyright 2004 The Infectious Diseases Society of America</rights><rights>2004 by the Infectious Diseases Society of America 2004</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-cf830c4269909411fe8417ece3edcf686dd191ea74a883cb20c693aaa8bc6fde3</citedby><cites>FETCH-LOGICAL-c453t-cf830c4269909411fe8417ece3edcf686dd191ea74a883cb20c693aaa8bc6fde3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4483761$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4483761$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27903,27904,57995,58228</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15707566$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14765347$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Talbot, Thomas R.</creatorcontrib><creatorcontrib>Ziel, Ellis</creatorcontrib><creatorcontrib>Doersam, Jennifer K.</creatorcontrib><creatorcontrib>LaFleur, Bonnie</creatorcontrib><creatorcontrib>Tollefson, Sharon</creatorcontrib><creatorcontrib>Edwards, Kathryn M.</creatorcontrib><title>Risk of Vaccinia Transfer to the Hands of Vaccinated Persons after Smallpox Immunization</title><title>Clinical infectious diseases</title><addtitle>Clinical Infectious Diseases</addtitle><addtitle>Clinical Infectious Diseases</addtitle><description>Transmission of vaccinia virus after smallpox vaccination is a concern. We conducted a prospective examination of the protection afforded by vaccination-site bandages in recently vaccinated individuals. After smallpox vaccination, inoculation sites were covered with 2 occlusive dressings. Site assessment and bandage changes occurred every 3-5 days until the site was healed. At each visit, specimens from the vaccination site, outer dressing surface, and contralateral hand were obtained for vaccinia culture. For 148 vaccinated subjects, vaccinia was detected from vaccination lesions of every subject on several occasions. Only 6 (0.65%) of 918 dressing (95% CI, 0.24%-1.4%) and 2 (0.22%) of 926 hand (95% CI, 0.03%-0.78%) specimens tested positive for vaccinia. The mean number of bandage changes was 9.6 (95% CI, 9.17-10.0). Vaccinia autoinoculation did not occur. The rate of vaccinia recovery outside occlusive bandages covering smallpox vaccination sites was remarkably low, suggesting excellent protection against inadvertent transmission.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Disease transmission</subject><subject>Female</subject><subject>Hand - virology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Lesions</subject><subject>Major Articles</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Occlusive Dressings</subject><subject>Risk Factors</subject><subject>Smallpox</subject><subject>Smallpox - prevention & control</subject><subject>Smallpox Vaccine - administration & dosage</subject><subject>Smallpox Vaccine - adverse effects</subject><subject>Smallpox, monkey pox, tanapox</subject><subject>Specimens</subject><subject>Surveillance</subject><subject>Tropical viral diseases</subject><subject>Vaccination</subject><subject>Vaccination - adverse effects</subject><subject>Vaccinia</subject><subject>Vaccinia - transmission</subject><subject>Vaccinia virus</subject><subject>Viral diseases</subject><subject>Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye</subject><subject>Wound dressings</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U1rFDEcBvAgFvuifgKR6UFvo8nm_WiLdSsFy7pK8RL-m0kw7cxkTTJQ_fSmzNI9iacEnh9P4AlCLwl-R7AS76kiC8yfoCPCqWwF1-RpvWOuWqaoOkTHOd9iTIjC_Bk6JEwKTpk8QjerkO-a6JvvYG0YAzTrBGP2LjUlNuWna5YwdnkvoLiuuXYpxzE34EuFXwfo-228by6HYRrDHyghjs_RgYc-uxe78wR9u_i4Pl-2V18-XZ5_uGot47S01iuKLVsIrbFmhHinGJHOOuo664USXUc0cSAZKEXtZoGt0BQA1MYK3zl6gt7OvdsUf00uFzOEbF3fw-jilI3CpNYS_V9IpOZ1HbqHNsWck_Nmm8IA6bch2DyMbeaxK3y9a5w2g-v2bLduBW92ALKF3tdlbch7xyWWXIjqTmcXp-2_H3s1m9tcYnpUrH6vFKTG7RyHXNz9YwzpzghJJTfLmx9mvdCfz8T1yqzoX1osqHc</recordid><startdate>20040215</startdate><enddate>20040215</enddate><creator>Talbot, Thomas R.</creator><creator>Ziel, Ellis</creator><creator>Doersam, Jennifer K.</creator><creator>LaFleur, Bonnie</creator><creator>Tollefson, Sharon</creator><creator>Edwards, Kathryn M.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20040215</creationdate><title>Risk of Vaccinia Transfer to the Hands of Vaccinated Persons after Smallpox Immunization</title><author>Talbot, Thomas R. ; Ziel, Ellis ; Doersam, Jennifer K. ; LaFleur, Bonnie ; Tollefson, Sharon ; Edwards, Kathryn M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-cf830c4269909411fe8417ece3edcf686dd191ea74a883cb20c693aaa8bc6fde3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Disease transmission</topic><topic>Female</topic><topic>Hand - virology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Lesions</topic><topic>Major Articles</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Occlusive Dressings</topic><topic>Risk Factors</topic><topic>Smallpox</topic><topic>Smallpox - prevention & control</topic><topic>Smallpox Vaccine - administration & dosage</topic><topic>Smallpox Vaccine - adverse effects</topic><topic>Smallpox, monkey pox, tanapox</topic><topic>Specimens</topic><topic>Surveillance</topic><topic>Tropical viral diseases</topic><topic>Vaccination</topic><topic>Vaccination - adverse effects</topic><topic>Vaccinia</topic><topic>Vaccinia - transmission</topic><topic>Vaccinia virus</topic><topic>Viral diseases</topic><topic>Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye</topic><topic>Wound dressings</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Talbot, Thomas R.</creatorcontrib><creatorcontrib>Ziel, Ellis</creatorcontrib><creatorcontrib>Doersam, Jennifer K.</creatorcontrib><creatorcontrib>LaFleur, Bonnie</creatorcontrib><creatorcontrib>Tollefson, Sharon</creatorcontrib><creatorcontrib>Edwards, Kathryn M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Talbot, Thomas R.</au><au>Ziel, Ellis</au><au>Doersam, Jennifer K.</au><au>LaFleur, Bonnie</au><au>Tollefson, Sharon</au><au>Edwards, Kathryn M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk of Vaccinia Transfer to the Hands of Vaccinated Persons after Smallpox Immunization</atitle><jtitle>Clinical infectious diseases</jtitle><stitle>Clinical Infectious Diseases</stitle><addtitle>Clinical Infectious Diseases</addtitle><date>2004-02-15</date><risdate>2004</risdate><volume>38</volume><issue>4</issue><spage>536</spage><epage>541</epage><pages>536-541</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><coden>CIDIEL</coden><abstract>Transmission of vaccinia virus after smallpox vaccination is a concern. We conducted a prospective examination of the protection afforded by vaccination-site bandages in recently vaccinated individuals. After smallpox vaccination, inoculation sites were covered with 2 occlusive dressings. Site assessment and bandage changes occurred every 3-5 days until the site was healed. At each visit, specimens from the vaccination site, outer dressing surface, and contralateral hand were obtained for vaccinia culture. For 148 vaccinated subjects, vaccinia was detected from vaccination lesions of every subject on several occasions. Only 6 (0.65%) of 918 dressing (95% CI, 0.24%-1.4%) and 2 (0.22%) of 926 hand (95% CI, 0.03%-0.78%) specimens tested positive for vaccinia. The mean number of bandage changes was 9.6 (95% CI, 9.17-10.0). Vaccinia autoinoculation did not occur. The rate of vaccinia recovery outside occlusive bandages covering smallpox vaccination sites was remarkably low, suggesting excellent protection against inadvertent transmission.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>14765347</pmid><doi>10.1086/381205</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Biological and medical sciences Disease transmission Female Hand - virology Human viral diseases Humans Infectious diseases Lesions Major Articles Male Medical sciences Occlusive Dressings Risk Factors Smallpox Smallpox - prevention & control Smallpox Vaccine - administration & dosage Smallpox Vaccine - adverse effects Smallpox, monkey pox, tanapox Specimens Surveillance Tropical viral diseases Vaccination Vaccination - adverse effects Vaccinia Vaccinia - transmission Vaccinia virus Viral diseases Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye Wound dressings |
| title | Risk of Vaccinia Transfer to the Hands of Vaccinated Persons after Smallpox Immunization |
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