PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide
Platelet-activating factor (PAF) induces pulmonary edema and has a key role in acute lung injury (ALI). Here we show that PAF induces pulmonary edema through two mechanisms: acid sphingomyelinase (ASM)-dependent production of ceramide, and activation of the cyclooxygenase pathway. Agents that interf...
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| Veröffentlicht in: | Nature medicine 2004-02, Vol.10 (2), p.155-160 |
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| creator | Göggel, Rolf Winoto-Morbach, Supandi Vielhaber, Gabriele Imai, Yumiko Lindner, Karsten Brade, Lore Brade, Helmut Ehlers, Stefan Slutsky, Arthur S Schütze, Stefan Gulbins, Erich Uhlig, Stefan |
| description | Platelet-activating factor (PAF) induces pulmonary edema and has a key role in acute lung injury (ALI). Here we show that PAF induces pulmonary edema through two mechanisms: acid sphingomyelinase (ASM)-dependent production of ceramide, and activation of the cyclooxygenase pathway. Agents that interfere with PAF-induced ceramide synthesis, such as steroids or the xanthogenate D609, attenuate pulmonary edema formation induced by PAF, endotoxin or acid instillation. Our results identify acid sphingomyelinase and ceramide as possible therapeutic targets in acute lung injury. |
| doi_str_mv | 10.1038/nm977 |
| format | Article |
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Our results identify acid sphingomyelinase and ceramide as possible therapeutic targets in acute lung injury.</description><identifier>ISSN: 1078-8956</identifier><identifier>EISSN: 1546-170X</identifier><identifier>DOI: 10.1038/nm977</identifier><identifier>PMID: 14704790</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Animals ; Antibodies - metabolism ; Antibodies - therapeutic use ; Biomedical and Life Sciences ; Biomedicine ; Bridged-Ring Compounds - metabolism ; Cancer Research ; Ceramides - metabolism ; Dexamethasone - metabolism ; Edema ; Endotoxins ; Female ; Glucocorticoids - metabolism ; In Vitro Techniques ; Infectious Diseases ; Metabolic Diseases ; Mice ; Mice, Inbred BALB C ; Molecular Medicine ; Neurosciences ; Phosphodiesterase Inhibitors - metabolism ; Platelet Activating Factor - metabolism ; Pulmonary Edema - drug therapy ; Pulmonary Edema - metabolism ; Rats ; Rats, Wistar ; Sphingomyelin Phosphodiesterase - antagonists & inhibitors ; Sphingomyelin Phosphodiesterase - metabolism ; Steroids ; Thiones - metabolism</subject><ispartof>Nature medicine, 2004-02, Vol.10 (2), p.155-160</ispartof><rights>Springer Nature America, Inc. 2004</rights><rights>COPYRIGHT 2004 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Feb 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-e45fc3a0a7dc1c9c507b3115704daa3b1d4d01e4c166deae2414accaea3f7efb3</citedby><cites>FETCH-LOGICAL-c509t-e45fc3a0a7dc1c9c507b3115704daa3b1d4d01e4c166deae2414accaea3f7efb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nm977$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nm977$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14704790$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Göggel, Rolf</creatorcontrib><creatorcontrib>Winoto-Morbach, Supandi</creatorcontrib><creatorcontrib>Vielhaber, Gabriele</creatorcontrib><creatorcontrib>Imai, Yumiko</creatorcontrib><creatorcontrib>Lindner, Karsten</creatorcontrib><creatorcontrib>Brade, Lore</creatorcontrib><creatorcontrib>Brade, Helmut</creatorcontrib><creatorcontrib>Ehlers, Stefan</creatorcontrib><creatorcontrib>Slutsky, Arthur S</creatorcontrib><creatorcontrib>Schütze, Stefan</creatorcontrib><creatorcontrib>Gulbins, Erich</creatorcontrib><creatorcontrib>Uhlig, Stefan</creatorcontrib><title>PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide</title><title>Nature medicine</title><addtitle>Nat Med</addtitle><addtitle>Nat Med</addtitle><description>Platelet-activating factor (PAF) induces pulmonary edema and has a key role in acute lung injury (ALI). Here we show that PAF induces pulmonary edema through two mechanisms: acid sphingomyelinase (ASM)-dependent production of ceramide, and activation of the cyclooxygenase pathway. Agents that interfere with PAF-induced ceramide synthesis, such as steroids or the xanthogenate D609, attenuate pulmonary edema formation induced by PAF, endotoxin or acid instillation. 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Academic</collection><jtitle>Nature medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Göggel, Rolf</au><au>Winoto-Morbach, Supandi</au><au>Vielhaber, Gabriele</au><au>Imai, Yumiko</au><au>Lindner, Karsten</au><au>Brade, Lore</au><au>Brade, Helmut</au><au>Ehlers, Stefan</au><au>Slutsky, Arthur S</au><au>Schütze, Stefan</au><au>Gulbins, Erich</au><au>Uhlig, Stefan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide</atitle><jtitle>Nature medicine</jtitle><stitle>Nat Med</stitle><addtitle>Nat Med</addtitle><date>2004-02-01</date><risdate>2004</risdate><volume>10</volume><issue>2</issue><spage>155</spage><epage>160</epage><pages>155-160</pages><issn>1078-8956</issn><eissn>1546-170X</eissn><abstract>Platelet-activating factor (PAF) induces pulmonary edema and has a key role in acute lung injury (ALI). Here we show that PAF induces pulmonary edema through two mechanisms: acid sphingomyelinase (ASM)-dependent production of ceramide, and activation of the cyclooxygenase pathway. Agents that interfere with PAF-induced ceramide synthesis, such as steroids or the xanthogenate D609, attenuate pulmonary edema formation induced by PAF, endotoxin or acid instillation. Our results identify acid sphingomyelinase and ceramide as possible therapeutic targets in acute lung injury.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>14704790</pmid><doi>10.1038/nm977</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Antibodies - metabolism Antibodies - therapeutic use Biomedical and Life Sciences Biomedicine Bridged-Ring Compounds - metabolism Cancer Research Ceramides - metabolism Dexamethasone - metabolism Edema Endotoxins Female Glucocorticoids - metabolism In Vitro Techniques Infectious Diseases Metabolic Diseases Mice Mice, Inbred BALB C Molecular Medicine Neurosciences Phosphodiesterase Inhibitors - metabolism Platelet Activating Factor - metabolism Pulmonary Edema - drug therapy Pulmonary Edema - metabolism Rats Rats, Wistar Sphingomyelin Phosphodiesterase - antagonists & inhibitors Sphingomyelin Phosphodiesterase - metabolism Steroids Thiones - metabolism |
| title | PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide |
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