Antiproliferative Activity of the Main Constituents from Phyllanthus emblica
Eighteen main compounds, including four norsesquiterpenoids (1-4) and 14 phenolic compounds (5-18) isolated previously from Phyllanthus emblica, together with a main constituent, proanthocyanidin polymers (19) identified at this time from the roots, were estimated for their antiproliferative activit...
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| Veröffentlicht in: | Biological & Pharmaceutical Bulletin 2004, Vol.27(2), pp.251-255 |
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| creator | Zhang, Ying-Jun Nagao, Tsuneatsu Tanaka, Takashi Yang, Chong-Ren Okabe, Hikaru Kouno, Isao |
| description | Eighteen main compounds, including four norsesquiterpenoids (1-4) and 14 phenolic compounds (5-18) isolated previously from Phyllanthus emblica, together with a main constituent, proanthocyanidin polymers (19) identified at this time from the roots, were estimated for their antiproliferative activities against MK-1 (human gastric adenocarcinoma), HeLa (human uterine carcinoma), and B16F10 (murine melanoma) cells using an MTT method. All of the phenolic compounds including the major components 5-8 from the fruit juice, 8, 9, and 12 from the branches and leaves, and 19 from the roots showed stronger inhibition against B16F10 cell growth than against HeLa and MK-1 cell growth. Norsesquiterpenoid glycosides 3 and 4 from the roots exhibited significant antiproliferative activities, although their aglycon 1 and monoglucoside 2 showed no inhibitory activity against these tumor cells. |
| doi_str_mv | 10.1248/bpb.27.251 |
| format | Article |
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All of the phenolic compounds including the major components 5-8 from the fruit juice, 8, 9, and 12 from the branches and leaves, and 19 from the roots showed stronger inhibition against B16F10 cell growth than against HeLa and MK-1 cell growth. Norsesquiterpenoid glycosides 3 and 4 from the roots exhibited significant antiproliferative activities, although their aglycon 1 and monoglucoside 2 showed no inhibitory activity against these tumor cells.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.27.251</identifier><identifier>PMID: 14758047</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Animals ; Antineoplastic Agents, Phytogenic - isolation & purification ; Antineoplastic Agents, Phytogenic - pharmacology ; antiproliferative activity ; B16F10 cell ; Cell Line, Tumor ; Drug Screening Assays, Antitumor ; Euphorbiaceae ; Fruit - chemistry ; Growth Inhibitors - isolation & purification ; Growth Inhibitors - pharmacology ; HeLa cell ; Humans ; Mice ; MK-1 cell ; Phenols - isolation & purification ; Phenols - pharmacology ; Phyllanthus emblica ; Phyllanthus emblica - chemistry ; Plant Leaves - chemistry ; Plant Roots - chemistry ; Plant Stems - chemistry ; Sesquiterpenes - isolation & purification ; Sesquiterpenes - pharmacology</subject><ispartof>Biological and Pharmaceutical Bulletin, 2004, Vol.27(2), pp.251-255</ispartof><rights>2004 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c727t-5b5dbe563c6a593a28eff5bad8df25e7801916eaadec06b27e1e0a689ddfe3c53</citedby><cites>FETCH-LOGICAL-c727t-5b5dbe563c6a593a28eff5bad8df25e7801916eaadec06b27e1e0a689ddfe3c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14758047$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Ying-Jun</creatorcontrib><creatorcontrib>Nagao, Tsuneatsu</creatorcontrib><creatorcontrib>Tanaka, Takashi</creatorcontrib><creatorcontrib>Yang, Chong-Ren</creatorcontrib><creatorcontrib>Okabe, Hikaru</creatorcontrib><creatorcontrib>Kouno, Isao</creatorcontrib><creatorcontrib>Faculty of Pharmaceutical Sciences</creatorcontrib><creatorcontrib>Fukuoka University</creatorcontrib><creatorcontrib>State Key Laboratory of Phytochemistrv & Plant Resources in West China</creatorcontrib><creatorcontrib>Chinese Academy of Sciences</creatorcontrib><creatorcontrib>Kunming Institute of Botany</creatorcontrib><creatorcontrib>Nagasaki University</creatorcontrib><title>Antiproliferative Activity of the Main Constituents from Phyllanthus emblica</title><title>Biological & Pharmaceutical Bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>Eighteen main compounds, including four norsesquiterpenoids (1-4) and 14 phenolic compounds (5-18) isolated previously from Phyllanthus emblica, together with a main constituent, proanthocyanidin polymers (19) identified at this time from the roots, were estimated for their antiproliferative activities against MK-1 (human gastric adenocarcinoma), HeLa (human uterine carcinoma), and B16F10 (murine melanoma) cells using an MTT method. All of the phenolic compounds including the major components 5-8 from the fruit juice, 8, 9, and 12 from the branches and leaves, and 19 from the roots showed stronger inhibition against B16F10 cell growth than against HeLa and MK-1 cell growth. Norsesquiterpenoid glycosides 3 and 4 from the roots exhibited significant antiproliferative activities, although their aglycon 1 and monoglucoside 2 showed no inhibitory activity against these tumor cells.</description><subject>Animals</subject><subject>Antineoplastic Agents, Phytogenic - isolation & purification</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>antiproliferative activity</subject><subject>B16F10 cell</subject><subject>Cell Line, Tumor</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Euphorbiaceae</subject><subject>Fruit - chemistry</subject><subject>Growth Inhibitors - isolation & purification</subject><subject>Growth Inhibitors - pharmacology</subject><subject>HeLa cell</subject><subject>Humans</subject><subject>Mice</subject><subject>MK-1 cell</subject><subject>Phenols - isolation & purification</subject><subject>Phenols - pharmacology</subject><subject>Phyllanthus emblica</subject><subject>Phyllanthus emblica - chemistry</subject><subject>Plant Leaves - chemistry</subject><subject>Plant Roots - chemistry</subject><subject>Plant Stems - chemistry</subject><subject>Sesquiterpenes - isolation & purification</subject><subject>Sesquiterpenes - pharmacology</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU2LFDEQhoMo7rh68QdIg-BB6DEfnY8-yTDoKozoQc8hna44GbqTMUkvzL83w4y74CFVh3ry1stbCL0meE1opz4Mx2FN5Zpy8gStCOtkyynhT9EK90S1gnB1g17kfMAYS0zZc3RDOskV7uQK7Tah-GOKk3eQTPH30Gxsbb6cmuiasofmm_Gh2caQiy8LhJIbl-Lc_NifpsmEsl9yA_MweWteomfOTBleXfst-vX508_tl3b3_e7rdrNrraSytHzg4wBcMCsM75mhCpzjgxnV6CgHqTDpiQBjRrBYDFQCAWyE6sfRAbOc3aJ3F91q_M8CuejZZwtnOxCXrKsAU4SJCr79DzzEJYXqTZOu6xkTSnSVen-hbIo5J3D6mPxs0kkTrM8J65qwplLXhCv85iq5DDOMj-g10grcXYA6rZlMMUw-wONim-Xg4xQ1xbjTGNN6E40pPz9yLpxgSQVVVenjRemQi_kND6tMKt5O8ODqWurvfxO7N0lDYH8BEeqkvg</recordid><startdate>20040201</startdate><enddate>20040201</enddate><creator>Zhang, Ying-Jun</creator><creator>Nagao, Tsuneatsu</creator><creator>Tanaka, Takashi</creator><creator>Yang, Chong-Ren</creator><creator>Okabe, Hikaru</creator><creator>Kouno, Isao</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20040201</creationdate><title>Antiproliferative Activity of the Main Constituents from Phyllanthus emblica</title><author>Zhang, Ying-Jun ; Nagao, Tsuneatsu ; Tanaka, Takashi ; Yang, Chong-Ren ; Okabe, Hikaru ; Kouno, Isao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c727t-5b5dbe563c6a593a28eff5bad8df25e7801916eaadec06b27e1e0a689ddfe3c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Antineoplastic Agents, Phytogenic - isolation & purification</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>antiproliferative activity</topic><topic>B16F10 cell</topic><topic>Cell Line, Tumor</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Euphorbiaceae</topic><topic>Fruit - chemistry</topic><topic>Growth Inhibitors - isolation & purification</topic><topic>Growth Inhibitors - pharmacology</topic><topic>HeLa cell</topic><topic>Humans</topic><topic>Mice</topic><topic>MK-1 cell</topic><topic>Phenols - isolation & purification</topic><topic>Phenols - pharmacology</topic><topic>Phyllanthus emblica</topic><topic>Phyllanthus emblica - chemistry</topic><topic>Plant Leaves - chemistry</topic><topic>Plant Roots - chemistry</topic><topic>Plant Stems - chemistry</topic><topic>Sesquiterpenes - isolation & purification</topic><topic>Sesquiterpenes - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Ying-Jun</creatorcontrib><creatorcontrib>Nagao, Tsuneatsu</creatorcontrib><creatorcontrib>Tanaka, Takashi</creatorcontrib><creatorcontrib>Yang, Chong-Ren</creatorcontrib><creatorcontrib>Okabe, Hikaru</creatorcontrib><creatorcontrib>Kouno, Isao</creatorcontrib><creatorcontrib>Faculty of Pharmaceutical Sciences</creatorcontrib><creatorcontrib>Fukuoka University</creatorcontrib><creatorcontrib>State Key Laboratory of Phytochemistrv & Plant Resources in West China</creatorcontrib><creatorcontrib>Chinese Academy of Sciences</creatorcontrib><creatorcontrib>Kunming Institute of Botany</creatorcontrib><creatorcontrib>Nagasaki University</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & Pharmaceutical Bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Ying-Jun</au><au>Nagao, Tsuneatsu</au><au>Tanaka, Takashi</au><au>Yang, Chong-Ren</au><au>Okabe, Hikaru</au><au>Kouno, Isao</au><aucorp>Faculty of Pharmaceutical Sciences</aucorp><aucorp>Fukuoka University</aucorp><aucorp>State Key Laboratory of Phytochemistrv & Plant Resources in West China</aucorp><aucorp>Chinese Academy of Sciences</aucorp><aucorp>Kunming Institute of Botany</aucorp><aucorp>Nagasaki University</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiproliferative Activity of the Main Constituents from Phyllanthus emblica</atitle><jtitle>Biological & Pharmaceutical Bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2004-02-01</date><risdate>2004</risdate><volume>27</volume><issue>2</issue><spage>251</spage><epage>255</epage><pages>251-255</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>Eighteen main compounds, including four norsesquiterpenoids (1-4) and 14 phenolic compounds (5-18) isolated previously from Phyllanthus emblica, together with a main constituent, proanthocyanidin polymers (19) identified at this time from the roots, were estimated for their antiproliferative activities against MK-1 (human gastric adenocarcinoma), HeLa (human uterine carcinoma), and B16F10 (murine melanoma) cells using an MTT method. All of the phenolic compounds including the major components 5-8 from the fruit juice, 8, 9, and 12 from the branches and leaves, and 19 from the roots showed stronger inhibition against B16F10 cell growth than against HeLa and MK-1 cell growth. Norsesquiterpenoid glycosides 3 and 4 from the roots exhibited significant antiproliferative activities, although their aglycon 1 and monoglucoside 2 showed no inhibitory activity against these tumor cells.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>14758047</pmid><doi>10.1248/bpb.27.251</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology antiproliferative activity B16F10 cell Cell Line, Tumor Drug Screening Assays, Antitumor Euphorbiaceae Fruit - chemistry Growth Inhibitors - isolation & purification Growth Inhibitors - pharmacology HeLa cell Humans Mice MK-1 cell Phenols - isolation & purification Phenols - pharmacology Phyllanthus emblica Phyllanthus emblica - chemistry Plant Leaves - chemistry Plant Roots - chemistry Plant Stems - chemistry Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology |
| title | Antiproliferative Activity of the Main Constituents from Phyllanthus emblica |
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