Response to Tricyclic Antidepressants: Independent of Gender?
OBJECTIVE: The authors examined gender differences in response to tricyclic antidepressants. METHOD: A total of 30 randomized, placebo-controlled trials that included 3,886 patients (1,555 men and 2,331 women), submitted between 1979 and 1991 in order to obtain marketing authorization, were reviewed...
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| Veröffentlicht in: | The American journal of psychiatry 2004-02, Vol.161 (2), p.370-372 |
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| container_end_page | 372 |
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| container_issue | 2 |
| container_start_page | 370 |
| container_title | The American journal of psychiatry |
| container_volume | 161 |
| creator | Wohlfarth, Tamar Storosum, Jitschak G. Elferink, André J.A. van Zwieten, Barbara J. Fouwels, Annemarie van den Brink, Wim |
| description | OBJECTIVE: The authors examined gender differences in response to tricyclic antidepressants. METHOD: A total of 30 randomized, placebo-controlled trials that included 3,886 patients (1,555 men and 2,331 women), submitted between 1979 and 1991 in order to obtain marketing authorization, were reviewed. Gender differences in response to treatment were tested in various multiple regression models using a variety of response definitions. RESULTS: Different response definitions all pointed to no gender difference in the efficacy of tricyclic antidepressants. The estimated effect size was similar for women younger and older than age 50 and for men. CONCLUSIONS: Tricyclic antidepressant response is independent of gender. |
| doi_str_mv | 10.1176/appi.ajp.161.2.370 |
| format | Article |
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METHOD: A total of 30 randomized, placebo-controlled trials that included 3,886 patients (1,555 men and 2,331 women), submitted between 1979 and 1991 in order to obtain marketing authorization, were reviewed. Gender differences in response to treatment were tested in various multiple regression models using a variety of response definitions. RESULTS: Different response definitions all pointed to no gender difference in the efficacy of tricyclic antidepressants. The estimated effect size was similar for women younger and older than age 50 and for men. CONCLUSIONS: Tricyclic antidepressant response is independent of gender.</description><subject>Antidepressants</subject><subject>Antidepressive Agents, Tricyclic - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Depressive Disorder, Major - diagnosis</subject><subject>Depressive Disorder, Major - drug therapy</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Gender differences</subject><subject>Humans</subject><subject>Male</subject><subject>Marketing</subject><subject>Medical sciences</subject><subject>Mental depression</subject><subject>Neuropharmacology</subject><subject>Patients</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Severity of Illness Index</subject><subject>Sex Factors</subject><issn>0002-953X</issn><issn>1535-7228</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKw0AUQAdRbK3-gAsJgu6SznsSQaQUrYWCIBXcDbeTCaSkSZxJF_17J7ZYcOHmPuDcBweha4ITQpQcQ9uWCazbhEiS0IQpfIKGRDARK0rTUzTEGNM4E-xzgC68X4cWM0XP0YBwJbjKyBA9vlvfNrW3UddES1eanalKE03qrsxt66z3UHf-IZrXobUh1F3UFNGsL93TJToroPL26pBH6OPleTl9jRdvs_l0soiBZbKLgaRMcotTwngqjEyFJLkCKFSKFV1xA0Ks0hxbToBnpgDCmRGApcnpikrCRuh-v7d1zdfW-k5vSm9sVUFtm63XKSZMKtWDt3_AdbN1dfhNU4p5RhnPAkT3kHGN984WunXlBtxOE6x7s7o3q4NZHcxqqoPZMHRz2LxdbWx-HDmoDMDdAQBvoCoc1Kb0R66nmFCBG--5nyO_7_1z-huqYJEh</recordid><startdate>20040201</startdate><enddate>20040201</enddate><creator>Wohlfarth, Tamar</creator><creator>Storosum, Jitschak G.</creator><creator>Elferink, André J.A.</creator><creator>van Zwieten, Barbara J.</creator><creator>Fouwels, Annemarie</creator><creator>van den Brink, Wim</creator><general>American Psychiatric Publishing</general><general>American Psychiatric Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20040201</creationdate><title>Response to Tricyclic Antidepressants: Independent of Gender?</title><author>Wohlfarth, Tamar ; Storosum, Jitschak G. ; Elferink, André J.A. ; van Zwieten, Barbara J. ; Fouwels, Annemarie ; van den Brink, Wim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a396t-a18364e0813485c68561d7aaf78072b4ca55b8d0e41a49cfa143c5a06cd2b2613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Antidepressants</topic><topic>Antidepressive Agents, Tricyclic - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Depressive Disorder, Major - diagnosis</topic><topic>Depressive Disorder, Major - drug therapy</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Gender differences</topic><topic>Humans</topic><topic>Male</topic><topic>Marketing</topic><topic>Medical sciences</topic><topic>Mental depression</topic><topic>Neuropharmacology</topic><topic>Patients</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. 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| source | MEDLINE; American Psychiatric Publishing Journals (1997-Present); Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Antidepressants Antidepressive Agents, Tricyclic - therapeutic use Biological and medical sciences Depressive Disorder, Major - diagnosis Depressive Disorder, Major - drug therapy Double-Blind Method Female Gender differences Humans Male Marketing Medical sciences Mental depression Neuropharmacology Patients Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Severity of Illness Index Sex Factors |
| title | Response to Tricyclic Antidepressants: Independent of Gender? |
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