FAK–Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly

Cell migration is a complex, highly regulated process that involves the continuous formation and disassembly of adhesions (adhesion turnover). Adhesion formation takes place at the leading edge of protrusions, whereas disassembly occurs both at the cell rear and at the base of protrusions. Despite t...

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Veröffentlicht in:	Nature cell biology 2004-02, Vol.6 (2), p.154-161
Hauptverfasser:	Webb, Donna J., Donais, Karen, Whitmore, Leanna A., Thomas, Sheila M., Turner, Christopher E., Parsons, J. Thomas, Horwitz, Alan F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Vesicular Transport - metabolism Adhesion Animals Biomedical and Life Sciences Cancer Research Cell Adhesion - physiology Cell adhesion molecules Cell Biology Cell Movement - physiology Cellular signal transduction Crk-Associated Substrate Protein Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism Developmental Biology Fibroblasts - cytology Fibroblasts - physiology Focal Adhesion Kinase 1 Focal Adhesion Protein-Tyrosine Kinases Genetic aspects letter Life Sciences Mice Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinases - metabolism Myosin-Light-Chain Kinase - genetics Myosin-Light-Chain Kinase - metabolism Paxillin Phosphoproteins - genetics Phosphoproteins - metabolism Physiological aspects Protein kinases Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism Proteins Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Retinoblastoma-Like Protein p130 Signal Transduction - physiology src-Family Kinases - genetics src-Family Kinases - metabolism Stem Cells
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