Expression of Valosin-Containing Protein in Colorectal Carcinomas as a Predictor for Disease Recurrence and Prognosis
Purpose: Valosin-containing protein (VCP or p97) is associated with antiapoptotic function and metastasis via activation of the nuclear factor-κB signaling pathway. The present study was designed to investigate the prognostic significance of VCP expression in colorectal adenocarcinoma. Experimental...
Gespeichert in:
| Veröffentlicht in: | Clinical cancer research 2004-01, Vol.10 (2), p.651-657 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 657 |
|---|---|
| container_issue | 2 |
| container_start_page | 651 |
| container_title | Clinical cancer research |
| container_volume | 10 |
| creator | YAMAMOTO, Shinji TOMITA, Yasuhiko HOSHIDA, Yoshihiko SAKON, Masato KAMEYAMA, Masao IMAOKA, Shingi SEKIMOTO, Mitsugu NAKAMORI, Shoji MONDEN, Morito AOZASA, Katsuyuki |
| description | Purpose: Valosin-containing protein (VCP or p97) is associated with antiapoptotic function and metastasis via activation of the nuclear
factor-κB signaling pathway. The present study was designed to investigate the prognostic significance of VCP expression in
colorectal adenocarcinoma.
Experimental Design: We analyzed VCP expression immunohistochemically in 129 patients with colorectal carcinoma ages 35–84 years. The staining
intensity of tumor cells was categorized as either weaker-to-equal (low VCP expression) or stronger (high expression) than
that in noncancerous colonic mucosa. We also analyzed 8 colorectal adenomas and 10 metastatic foci.
Results: Low VCP expression was noted in 41 (31.8%) cases and high expression in 88 (68.2%) cases. A low level of VCP expression was
noted in all adenomas, whereas a high level was seen in all metastatic tumors. A significant difference was observed in depth
of invasion (T 1–2 versus T 3–4 , P < 0.05), presence or absence of venous invasion ( P < 0.05), and tumor stage (I and II versus III and IV; P < 0.05) between adenocarcinomas with low and high VCP expression. Patients with high VCP-expressing tumors had a higher recurrence
rate ( P < 0.001) and poorer disease-free and overall survival ( P < 0.01 and P < 0.05, respectively) compared with the low expression group. Multivariate analysis revealed VCP expression level to be an
independent prognosticator for both disease-free and overall survival. VCP level was an indicator of disease-free survival
in both stage II and III (pathological Tumor-Node-Metastasis classification, P < 0.05 and |
| doi_str_mv | 10.1158/1078-0432.CCR-1576-03 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80135966</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>80135966</sourcerecordid><originalsourceid>FETCH-LOGICAL-c482t-95d709f04bc383a6acf30d85869d3e3db109f829b8a18a3fa96c956bd2ce324b3</originalsourceid><addsrcrecordid>eNpFkF2L1TAQhoMo7rr6E5TcqFddk6ZJ00vprh-woCzqbZim03MiPckx06L-e1POkYUJCcwzb4aHsZdSXEup7TspWluJRtXXfX9fSd2aSqhH7FJq3VaqNvpxef9nLtgzop9CyEaK5im7kE1rhLD2kq23f44ZiUKKPE38B8yJQqz6FBcIMcQd_5rTgiHyUn2aU0a_wMx7yD7EdADiWxUKx-CXlPlUzk0gBEJ-j37NGaNHDnHconax5NNz9mSCmfDF-b5i3z_cfus_VXdfPn7u399VvrH1UnV6bEU3iWbwyiow4CclRqut6UaFahxk6dq6GyxIC2qCzvhOm2GsPaq6GdQVe3PKPeb0a0Va3CGQx3mGiGklZ4VUujOmgPoE-pyIMk7umMMB8l8nhdt8u82l21y64tttvp1QZe7V-YN1OOD4MHUWXIDXZwDIwzxliD7QA6cbbZTtCvf2xO3Dbv87ZHS-kFjkFZPZ77c9ame0VP8A06mX9g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>80135966</pqid></control><display><type>article</type><title>Expression of Valosin-Containing Protein in Colorectal Carcinomas as a Predictor for Disease Recurrence and Prognosis</title><source>MEDLINE</source><source>American Association for Cancer Research</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>YAMAMOTO, Shinji ; TOMITA, Yasuhiko ; HOSHIDA, Yoshihiko ; SAKON, Masato ; KAMEYAMA, Masao ; IMAOKA, Shingi ; SEKIMOTO, Mitsugu ; NAKAMORI, Shoji ; MONDEN, Morito ; AOZASA, Katsuyuki</creator><creatorcontrib>YAMAMOTO, Shinji ; TOMITA, Yasuhiko ; HOSHIDA, Yoshihiko ; SAKON, Masato ; KAMEYAMA, Masao ; IMAOKA, Shingi ; SEKIMOTO, Mitsugu ; NAKAMORI, Shoji ; MONDEN, Morito ; AOZASA, Katsuyuki</creatorcontrib><description><![CDATA[Purpose: Valosin-containing protein (VCP or p97) is associated with antiapoptotic function and metastasis via activation of the nuclear
factor-κB signaling pathway. The present study was designed to investigate the prognostic significance of VCP expression in
colorectal adenocarcinoma.
Experimental Design: We analyzed VCP expression immunohistochemically in 129 patients with colorectal carcinoma ages 35–84 years. The staining
intensity of tumor cells was categorized as either weaker-to-equal (low VCP expression) or stronger (high expression) than
that in noncancerous colonic mucosa. We also analyzed 8 colorectal adenomas and 10 metastatic foci.
Results: Low VCP expression was noted in 41 (31.8%) cases and high expression in 88 (68.2%) cases. A low level of VCP expression was
noted in all adenomas, whereas a high level was seen in all metastatic tumors. A significant difference was observed in depth
of invasion (T 1–2 versus T 3–4 , P < 0.05), presence or absence of venous invasion ( P < 0.05), and tumor stage (I and II versus III and IV; P < 0.05) between adenocarcinomas with low and high VCP expression. Patients with high VCP-expressing tumors had a higher recurrence
rate ( P < 0.001) and poorer disease-free and overall survival ( P < 0.01 and P < 0.05, respectively) compared with the low expression group. Multivariate analysis revealed VCP expression level to be an
independent prognosticator for both disease-free and overall survival. VCP level was an indicator of disease-free survival
in both stage II and III (pathological Tumor-Node-Metastasis classification, P < 0.05 and <0.01, respectively).
Conclusions: A high expression level of VCP in tumors is a poor prognostic marker in patients with colorectal carcinomas.]]></description><identifier>ISSN: 1078-0432</identifier><identifier>EISSN: 1557-3265</identifier><identifier>DOI: 10.1158/1078-0432.CCR-1576-03</identifier><identifier>PMID: 14760088</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Adenoma - pathology ; Adenosine Triphosphatases ; Adult ; Aged ; Aged, 80 and over ; Antineoplastic agents ; Apoptosis ; Biological and medical sciences ; Carcinoma - pathology ; Cell Cycle Proteins - biosynthesis ; Cell Cycle Proteins - metabolism ; Cell Line, Tumor ; Colorectal Neoplasms - metabolism ; Colorectal Neoplasms - pathology ; Disease-Free Survival ; Female ; Humans ; Immunohistochemistry ; Lymphatic Metastasis ; Male ; Medical sciences ; Middle Aged ; Mucous Membrane - pathology ; Multivariate Analysis ; Neoplasm Metastasis ; NF-kappa B - metabolism ; Pharmacology. Drug treatments ; Prognosis ; Recurrence ; Signal Transduction ; Time Factors ; Treatment Outcome ; Tumors ; Valosin Containing Protein</subject><ispartof>Clinical cancer research, 2004-01, Vol.10 (2), p.651-657</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-95d709f04bc383a6acf30d85869d3e3db109f829b8a18a3fa96c956bd2ce324b3</citedby><cites>FETCH-LOGICAL-c482t-95d709f04bc383a6acf30d85869d3e3db109f829b8a18a3fa96c956bd2ce324b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,3343,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15456389$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14760088$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>YAMAMOTO, Shinji</creatorcontrib><creatorcontrib>TOMITA, Yasuhiko</creatorcontrib><creatorcontrib>HOSHIDA, Yoshihiko</creatorcontrib><creatorcontrib>SAKON, Masato</creatorcontrib><creatorcontrib>KAMEYAMA, Masao</creatorcontrib><creatorcontrib>IMAOKA, Shingi</creatorcontrib><creatorcontrib>SEKIMOTO, Mitsugu</creatorcontrib><creatorcontrib>NAKAMORI, Shoji</creatorcontrib><creatorcontrib>MONDEN, Morito</creatorcontrib><creatorcontrib>AOZASA, Katsuyuki</creatorcontrib><title>Expression of Valosin-Containing Protein in Colorectal Carcinomas as a Predictor for Disease Recurrence and Prognosis</title><title>Clinical cancer research</title><addtitle>Clin Cancer Res</addtitle><description><![CDATA[Purpose: Valosin-containing protein (VCP or p97) is associated with antiapoptotic function and metastasis via activation of the nuclear
factor-κB signaling pathway. The present study was designed to investigate the prognostic significance of VCP expression in
colorectal adenocarcinoma.
Experimental Design: We analyzed VCP expression immunohistochemically in 129 patients with colorectal carcinoma ages 35–84 years. The staining
intensity of tumor cells was categorized as either weaker-to-equal (low VCP expression) or stronger (high expression) than
that in noncancerous colonic mucosa. We also analyzed 8 colorectal adenomas and 10 metastatic foci.
Results: Low VCP expression was noted in 41 (31.8%) cases and high expression in 88 (68.2%) cases. A low level of VCP expression was
noted in all adenomas, whereas a high level was seen in all metastatic tumors. A significant difference was observed in depth
of invasion (T 1–2 versus T 3–4 , P < 0.05), presence or absence of venous invasion ( P < 0.05), and tumor stage (I and II versus III and IV; P < 0.05) between adenocarcinomas with low and high VCP expression. Patients with high VCP-expressing tumors had a higher recurrence
rate ( P < 0.001) and poorer disease-free and overall survival ( P < 0.01 and P < 0.05, respectively) compared with the low expression group. Multivariate analysis revealed VCP expression level to be an
independent prognosticator for both disease-free and overall survival. VCP level was an indicator of disease-free survival
in both stage II and III (pathological Tumor-Node-Metastasis classification, P < 0.05 and <0.01, respectively).
Conclusions: A high expression level of VCP in tumors is a poor prognostic marker in patients with colorectal carcinomas.]]></description><subject>Adenoma - pathology</subject><subject>Adenosine Triphosphatases</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antineoplastic agents</subject><subject>Apoptosis</subject><subject>Biological and medical sciences</subject><subject>Carcinoma - pathology</subject><subject>Cell Cycle Proteins - biosynthesis</subject><subject>Cell Cycle Proteins - metabolism</subject><subject>Cell Line, Tumor</subject><subject>Colorectal Neoplasms - metabolism</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mucous Membrane - pathology</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Metastasis</subject><subject>NF-kappa B - metabolism</subject><subject>Pharmacology. Drug treatments</subject><subject>Prognosis</subject><subject>Recurrence</subject><subject>Signal Transduction</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><subject>Valosin Containing Protein</subject><issn>1078-0432</issn><issn>1557-3265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkF2L1TAQhoMo7rr6E5TcqFddk6ZJ00vprh-woCzqbZim03MiPckx06L-e1POkYUJCcwzb4aHsZdSXEup7TspWluJRtXXfX9fSd2aSqhH7FJq3VaqNvpxef9nLtgzop9CyEaK5im7kE1rhLD2kq23f44ZiUKKPE38B8yJQqz6FBcIMcQd_5rTgiHyUn2aU0a_wMx7yD7EdADiWxUKx-CXlPlUzk0gBEJ-j37NGaNHDnHconax5NNz9mSCmfDF-b5i3z_cfus_VXdfPn7u399VvrH1UnV6bEU3iWbwyiow4CclRqut6UaFahxk6dq6GyxIC2qCzvhOm2GsPaq6GdQVe3PKPeb0a0Va3CGQx3mGiGklZ4VUujOmgPoE-pyIMk7umMMB8l8nhdt8u82l21y64tttvp1QZe7V-YN1OOD4MHUWXIDXZwDIwzxliD7QA6cbbZTtCvf2xO3Dbv87ZHS-kFjkFZPZ77c9ame0VP8A06mX9g</recordid><startdate>20040115</startdate><enddate>20040115</enddate><creator>YAMAMOTO, Shinji</creator><creator>TOMITA, Yasuhiko</creator><creator>HOSHIDA, Yoshihiko</creator><creator>SAKON, Masato</creator><creator>KAMEYAMA, Masao</creator><creator>IMAOKA, Shingi</creator><creator>SEKIMOTO, Mitsugu</creator><creator>NAKAMORI, Shoji</creator><creator>MONDEN, Morito</creator><creator>AOZASA, Katsuyuki</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040115</creationdate><title>Expression of Valosin-Containing Protein in Colorectal Carcinomas as a Predictor for Disease Recurrence and Prognosis</title><author>YAMAMOTO, Shinji ; TOMITA, Yasuhiko ; HOSHIDA, Yoshihiko ; SAKON, Masato ; KAMEYAMA, Masao ; IMAOKA, Shingi ; SEKIMOTO, Mitsugu ; NAKAMORI, Shoji ; MONDEN, Morito ; AOZASA, Katsuyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-95d709f04bc383a6acf30d85869d3e3db109f829b8a18a3fa96c956bd2ce324b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adenoma - pathology</topic><topic>Adenosine Triphosphatases</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antineoplastic agents</topic><topic>Apoptosis</topic><topic>Biological and medical sciences</topic><topic>Carcinoma - pathology</topic><topic>Cell Cycle Proteins - biosynthesis</topic><topic>Cell Cycle Proteins - metabolism</topic><topic>Cell Line, Tumor</topic><topic>Colorectal Neoplasms - metabolism</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mucous Membrane - pathology</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Metastasis</topic><topic>NF-kappa B - metabolism</topic><topic>Pharmacology. Drug treatments</topic><topic>Prognosis</topic><topic>Recurrence</topic><topic>Signal Transduction</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><topic>Valosin Containing Protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>YAMAMOTO, Shinji</creatorcontrib><creatorcontrib>TOMITA, Yasuhiko</creatorcontrib><creatorcontrib>HOSHIDA, Yoshihiko</creatorcontrib><creatorcontrib>SAKON, Masato</creatorcontrib><creatorcontrib>KAMEYAMA, Masao</creatorcontrib><creatorcontrib>IMAOKA, Shingi</creatorcontrib><creatorcontrib>SEKIMOTO, Mitsugu</creatorcontrib><creatorcontrib>NAKAMORI, Shoji</creatorcontrib><creatorcontrib>MONDEN, Morito</creatorcontrib><creatorcontrib>AOZASA, Katsuyuki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YAMAMOTO, Shinji</au><au>TOMITA, Yasuhiko</au><au>HOSHIDA, Yoshihiko</au><au>SAKON, Masato</au><au>KAMEYAMA, Masao</au><au>IMAOKA, Shingi</au><au>SEKIMOTO, Mitsugu</au><au>NAKAMORI, Shoji</au><au>MONDEN, Morito</au><au>AOZASA, Katsuyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of Valosin-Containing Protein in Colorectal Carcinomas as a Predictor for Disease Recurrence and Prognosis</atitle><jtitle>Clinical cancer research</jtitle><addtitle>Clin Cancer Res</addtitle><date>2004-01-15</date><risdate>2004</risdate><volume>10</volume><issue>2</issue><spage>651</spage><epage>657</epage><pages>651-657</pages><issn>1078-0432</issn><eissn>1557-3265</eissn><abstract><![CDATA[Purpose: Valosin-containing protein (VCP or p97) is associated with antiapoptotic function and metastasis via activation of the nuclear
factor-κB signaling pathway. The present study was designed to investigate the prognostic significance of VCP expression in
colorectal adenocarcinoma.
Experimental Design: We analyzed VCP expression immunohistochemically in 129 patients with colorectal carcinoma ages 35–84 years. The staining
intensity of tumor cells was categorized as either weaker-to-equal (low VCP expression) or stronger (high expression) than
that in noncancerous colonic mucosa. We also analyzed 8 colorectal adenomas and 10 metastatic foci.
Results: Low VCP expression was noted in 41 (31.8%) cases and high expression in 88 (68.2%) cases. A low level of VCP expression was
noted in all adenomas, whereas a high level was seen in all metastatic tumors. A significant difference was observed in depth
of invasion (T 1–2 versus T 3–4 , P < 0.05), presence or absence of venous invasion ( P < 0.05), and tumor stage (I and II versus III and IV; P < 0.05) between adenocarcinomas with low and high VCP expression. Patients with high VCP-expressing tumors had a higher recurrence
rate ( P < 0.001) and poorer disease-free and overall survival ( P < 0.01 and P < 0.05, respectively) compared with the low expression group. Multivariate analysis revealed VCP expression level to be an
independent prognosticator for both disease-free and overall survival. VCP level was an indicator of disease-free survival
in both stage II and III (pathological Tumor-Node-Metastasis classification, P < 0.05 and <0.01, respectively).
Conclusions: A high expression level of VCP in tumors is a poor prognostic marker in patients with colorectal carcinomas.]]></abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>14760088</pmid><doi>10.1158/1078-0432.CCR-1576-03</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1078-0432 |
| ispartof | Clinical cancer research, 2004-01, Vol.10 (2), p.651-657 |
| issn | 1078-0432 1557-3265 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80135966 |
| source | MEDLINE; American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adenoma - pathology Adenosine Triphosphatases Adult Aged Aged, 80 and over Antineoplastic agents Apoptosis Biological and medical sciences Carcinoma - pathology Cell Cycle Proteins - biosynthesis Cell Cycle Proteins - metabolism Cell Line, Tumor Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Disease-Free Survival Female Humans Immunohistochemistry Lymphatic Metastasis Male Medical sciences Middle Aged Mucous Membrane - pathology Multivariate Analysis Neoplasm Metastasis NF-kappa B - metabolism Pharmacology. Drug treatments Prognosis Recurrence Signal Transduction Time Factors Treatment Outcome Tumors Valosin Containing Protein |
| title | Expression of Valosin-Containing Protein in Colorectal Carcinomas as a Predictor for Disease Recurrence and Prognosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T15%3A37%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Expression%20of%20Valosin-Containing%20Protein%20in%20Colorectal%20Carcinomas%20as%20a%20Predictor%20for%20Disease%20Recurrence%20and%20Prognosis&rft.jtitle=Clinical%20cancer%20research&rft.au=YAMAMOTO,%20Shinji&rft.date=2004-01-15&rft.volume=10&rft.issue=2&rft.spage=651&rft.epage=657&rft.pages=651-657&rft.issn=1078-0432&rft.eissn=1557-3265&rft_id=info:doi/10.1158/1078-0432.CCR-1576-03&rft_dat=%3Cproquest_cross%3E80135966%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=80135966&rft_id=info:pmid/14760088&rfr_iscdi=true |