The Influence of Relative Humidity on the Cohesion Properties of Micronized Drugs Used in Inhalation Therapy

The influence of relative humidity (RH) on the cohesion properties of three drugs: salbutamol sulphate (SS), triamcinolone acetonide (TAA), and disodium cromoglycate (DSCG) was investigated using the atomic force microscope (AFM) colloidal probe technique. Micronized drug particles were mounted in h...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2004-03, Vol.93 (3), p.753-761
Hauptverfasser:	Young, Paul M., Price, Robert, Tobyn, Michael J., Buttrum, Mark, Dey, Fiona
Format:	Artikel
Sprache:	eng
Schlagworte:	AFM Biological and medical sciences Bronchodilator Agents - chemistry cohesion Colloids - chemistry General pharmacology Humidity individual particle-particle measurements Medical sciences Microscopy, Atomic Force Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Powders relative humidity Respiratory Therapy - instrumentation Respiratory Therapy - methods Respiratory Therapy - standards separation energy/force
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