Correlation between quantitative antibody titers of sperm immobilizing antibodies and pregnancy rates by treatments
Immunological infertility in women who possessed sperm immobilizing (SI) antibodies made it very difficult to conceive using the usual treatments. We examined SI antibodies by the quantitative Sperm Immobilization Test and found the antibody titers (50% sperm immobilization unit: SI50 unit) associat...
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| Veröffentlicht in: | Fertility and sterility 1990-12, Vol.54 (6), p.1107-1113 |
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| container_title | Fertility and sterility |
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| creator | Kobayashi, Shinichiro Bessho, Takefumi Shigeta, Minoru Koyama, Koji Isojima, Shinzo |
| description | Immunological infertility in women who possessed sperm immobilizing (SI) antibodies made it very difficult to conceive using the usual treatments. We examined SI antibodies by the quantitative Sperm Immobilization Test and found the antibody titers (50% sperm immobilization unit: SI50 unit) associated with pregnancy rates. Patients with high SI50 titers (>10 units) did not conceive by ordinary or repeated artificial inseminations with husband’s semen (AIH) except when treated with in vitro fertilization (IVF) and embryo replacement. Patients with relatively low SI50 titers ( |
| doi_str_mv | 10.1016/S0015-0282(16)54013-8 |
| format | Article |
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We examined SI antibodies by the quantitative Sperm Immobilization Test and found the antibody titers (50% sperm immobilization unit: SI50 unit) associated with pregnancy rates. Patients with high SI50 titers (>10 units) did not conceive by ordinary or repeated artificial inseminations with husband’s semen (AIH) except when treated with in vitro fertilization (IVF) and embryo replacement. Patients with relatively low SI50 titers (<10 units) could conceive either by repeated or ordinary AIH, though the success rates were lower than by IVF-embryo replacement. It is important to assess the SI50 titers by the quantitative method to select treatments for infertile women with SI antibodies. In follow-up studies of the patients who conceived successfully, it was found that SI50 titers tended to decline as pregnancy proceeded.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/S0015-0282(16)54013-8</identifier><identifier>PMID: 2245837</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Antibodies - analysis ; Biological and medical sciences ; Birth control ; Embryo Transfer ; Female ; Fertilization ; Fertilization in Vitro ; Follow-Up Studies ; Gynecology. Andrology. Obstetrics ; Humans ; Infertility, Female - immunology ; Infertility, Female - physiopathology ; Infertility, Female - therapy ; Insemination, Artificial, Homologous ; Male ; Medical sciences ; Pregnancy - immunology ; Spermatozoa - immunology ; Sterility. 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We examined SI antibodies by the quantitative Sperm Immobilization Test and found the antibody titers (50% sperm immobilization unit: SI50 unit) associated with pregnancy rates. Patients with high SI50 titers (>10 units) did not conceive by ordinary or repeated artificial inseminations with husband’s semen (AIH) except when treated with in vitro fertilization (IVF) and embryo replacement. Patients with relatively low SI50 titers (<10 units) could conceive either by repeated or ordinary AIH, though the success rates were lower than by IVF-embryo replacement. It is important to assess the SI50 titers by the quantitative method to select treatments for infertile women with SI antibodies. In follow-up studies of the patients who conceived successfully, it was found that SI50 titers tended to decline as pregnancy proceeded.</description><subject>Antibodies - analysis</subject><subject>Biological and medical sciences</subject><subject>Birth control</subject><subject>Embryo Transfer</subject><subject>Female</subject><subject>Fertilization</subject><subject>Fertilization in Vitro</subject><subject>Follow-Up Studies</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Infertility, Female - immunology</subject><subject>Infertility, Female - physiopathology</subject><subject>Infertility, Female - therapy</subject><subject>Insemination, Artificial, Homologous</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pregnancy - immunology</subject><subject>Spermatozoa - immunology</subject><subject>Sterility. 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Andrology. Obstetrics</topic><topic>Humans</topic><topic>Infertility, Female - immunology</topic><topic>Infertility, Female - physiopathology</topic><topic>Infertility, Female - therapy</topic><topic>Insemination, Artificial, Homologous</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pregnancy - immunology</topic><topic>Spermatozoa - immunology</topic><topic>Sterility. Assisted procreation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kobayashi, Shinichiro</creatorcontrib><creatorcontrib>Bessho, Takefumi</creatorcontrib><creatorcontrib>Shigeta, Minoru</creatorcontrib><creatorcontrib>Koyama, Koji</creatorcontrib><creatorcontrib>Isojima, Shinzo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kobayashi, Shinichiro</au><au>Bessho, Takefumi</au><au>Shigeta, Minoru</au><au>Koyama, Koji</au><au>Isojima, Shinzo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation between quantitative antibody titers of sperm immobilizing antibodies and pregnancy rates by treatments</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>1990-12-01</date><risdate>1990</risdate><volume>54</volume><issue>6</issue><spage>1107</spage><epage>1113</epage><pages>1107-1113</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>Immunological infertility in women who possessed sperm immobilizing (SI) antibodies made it very difficult to conceive using the usual treatments. We examined SI antibodies by the quantitative Sperm Immobilization Test and found the antibody titers (50% sperm immobilization unit: SI50 unit) associated with pregnancy rates. Patients with high SI50 titers (>10 units) did not conceive by ordinary or repeated artificial inseminations with husband’s semen (AIH) except when treated with in vitro fertilization (IVF) and embryo replacement. Patients with relatively low SI50 titers (<10 units) could conceive either by repeated or ordinary AIH, though the success rates were lower than by IVF-embryo replacement. It is important to assess the SI50 titers by the quantitative method to select treatments for infertile women with SI antibodies. In follow-up studies of the patients who conceived successfully, it was found that SI50 titers tended to decline as pregnancy proceeded.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2245837</pmid><doi>10.1016/S0015-0282(16)54013-8</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Alma/SFX Local Collection; EZB* |
| subjects | Antibodies - analysis Biological and medical sciences Birth control Embryo Transfer Female Fertilization Fertilization in Vitro Follow-Up Studies Gynecology. Andrology. Obstetrics Humans Infertility, Female - immunology Infertility, Female - physiopathology Infertility, Female - therapy Insemination, Artificial, Homologous Male Medical sciences Pregnancy - immunology Spermatozoa - immunology Sterility. Assisted procreation |
| title | Correlation between quantitative antibody titers of sperm immobilizing antibodies and pregnancy rates by treatments |
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