Breakdown of the blood-brain barrier precedes symptoms and other MRI signs of new lesions in multiple sclerosis : pathogenetic and clinical implications

From an extensive serial magnetic resonance imaging (MRI) study in multiple sclerosis (MS) we have identified 4 cases in which disruption of the blood-brain barrier, as detected by gadolinium-DTPA enhancement, preceded other MRI abnormalities and in 1 case clinical evidence of the new lesion. This s...

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Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 1990-10, Vol.113 (5), p.1477-1489
Hauptverfasser:	KERMODE, A. G, THOMPSON, A. J, TOFTS, P, MACMANUS, D. G, KENDALL, B. E, KINGSLEY, D. P. E, MOSELEY, I. F, RUDGE, P, MCDONALD, W. I
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Blood-Brain Barrier Brain - pathology Contrast Media Disability Evaluation Female Gadolinium DTPA Humans Magnetic Resonance Imaging Male Medical sciences Middle Aged Multiple Sclerosis - diagnosis Multiple Sclerosis - metabolism Multiple Sclerosis - physiopathology Neurology Organometallic Compounds Pentetic Acid
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