Breakdown of the blood-brain barrier precedes symptoms and other MRI signs of new lesions in multiple sclerosis : pathogenetic and clinical implications
From an extensive serial magnetic resonance imaging (MRI) study in multiple sclerosis (MS) we have identified 4 cases in which disruption of the blood-brain barrier, as detected by gadolinium-DTPA enhancement, preceded other MRI abnormalities and in 1 case clinical evidence of the new lesion. This s...
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| Veröffentlicht in: | Brain (London, England : 1878) England : 1878), 1990-10, Vol.113 (5), p.1477-1489 |
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| container_issue | 5 |
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| container_title | Brain (London, England : 1878) |
| container_volume | 113 |
| creator | KERMODE, A. G THOMPSON, A. J TOFTS, P MACMANUS, D. G KENDALL, B. E KINGSLEY, D. P. E MOSELEY, I. F RUDGE, P MCDONALD, W. I |
| description | From an extensive serial magnetic resonance imaging (MRI) study in multiple sclerosis (MS) we have identified 4 cases in which disruption of the blood-brain barrier, as detected by gadolinium-DTPA enhancement, preceded other MRI abnormalities and in 1 case clinical evidence of the new lesion. This supports the view that a defect in the blood-brain barrier, and therefore inflammation, is an early and possibly crucial event in the pathogenesis of the new lesion in MS. These cases showed a marked discrepancy between MRI abnormality and symptoms. The mechanisms contributing to this disparity are discussed, and it is concluded that far from being surprising it is to be expected. |
| doi_str_mv | 10.1093/brain/113.5.1477 |
| format | Article |
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G ; THOMPSON, A. J ; TOFTS, P ; MACMANUS, D. G ; KENDALL, B. E ; KINGSLEY, D. P. E ; MOSELEY, I. F ; RUDGE, P ; MCDONALD, W. I</creator><creatorcontrib>KERMODE, A. G ; THOMPSON, A. J ; TOFTS, P ; MACMANUS, D. G ; KENDALL, B. E ; KINGSLEY, D. P. E ; MOSELEY, I. F ; RUDGE, P ; MCDONALD, W. I</creatorcontrib><description>From an extensive serial magnetic resonance imaging (MRI) study in multiple sclerosis (MS) we have identified 4 cases in which disruption of the blood-brain barrier, as detected by gadolinium-DTPA enhancement, preceded other MRI abnormalities and in 1 case clinical evidence of the new lesion. This supports the view that a defect in the blood-brain barrier, and therefore inflammation, is an early and possibly crucial event in the pathogenesis of the new lesion in MS. These cases showed a marked discrepancy between MRI abnormality and symptoms. The mechanisms contributing to this disparity are discussed, and it is concluded that far from being surprising it is to be expected.</description><identifier>ISSN: 0006-8950</identifier><identifier>EISSN: 1460-2156</identifier><identifier>DOI: 10.1093/brain/113.5.1477</identifier><identifier>PMID: 2245307</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Biological and medical sciences ; Blood-Brain Barrier ; Brain - pathology ; Contrast Media ; Disability Evaluation ; Female ; Gadolinium DTPA ; Humans ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Middle Aged ; Multiple Sclerosis - diagnosis ; Multiple Sclerosis - metabolism ; Multiple Sclerosis - physiopathology ; Neurology ; Organometallic Compounds ; Pentetic Acid</subject><ispartof>Brain (London, England : 1878), 1990-10, Vol.113 (5), p.1477-1489</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4614754$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2245307$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KERMODE, A. 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The mechanisms contributing to this disparity are discussed, and it is concluded that far from being surprising it is to be expected.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood-Brain Barrier</subject><subject>Brain - pathology</subject><subject>Contrast Media</subject><subject>Disability Evaluation</subject><subject>Female</subject><subject>Gadolinium DTPA</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multiple Sclerosis - diagnosis</subject><subject>Multiple Sclerosis - metabolism</subject><subject>Multiple Sclerosis - physiopathology</subject><subject>Neurology</subject><subject>Organometallic Compounds</subject><subject>Pentetic Acid</subject><issn>0006-8950</issn><issn>1460-2156</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kctuFDEQRS0ECkNgzwbJC8SuJ3607R52EPGIFISEYG257erE4LYbV4-i_Amfi2cyyqqqVPceqeoS8pqzLWc7eTFWF_MF53Krtrw35gnZ8F6zTnCln5INY0x3w06x5-QF4m_GeC-FPiNnQvRKMrMh_z5WcH9Cucu0THS9BTqmUkJ3BNPR1Rqh0qWChwBI8X5e1jIjdTnQ0uSVfvtxRTHeZDwAMtzRBBhLG5t_3qc1Lgko-gS1YET6ni5uvS03kGGN_sjxKeboXaJxXlJr1oP9JXk2uYTw6lTPya_Pn35efu2uv3-5uvxw3Xlh9NpNXgqjJqOEFpJrY-QwhUEMjCtmJhm0CG6QY5CejxomCGYHbAxOj9zpoIM8J-8euEstf_eAq50jekjJZSh7tI0kG1k1IXsQ-nYIVpjsUuPs6r3lzB7CsMef2RaGVfYQRrO8ObH34wzh0XD6ftu_Pe0dtvun6rKP-CjrdaOoXv4HSoqWJg</recordid><startdate>19901001</startdate><enddate>19901001</enddate><creator>KERMODE, A. 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G</creatorcontrib><creatorcontrib>THOMPSON, A. J</creatorcontrib><creatorcontrib>TOFTS, P</creatorcontrib><creatorcontrib>MACMANUS, D. G</creatorcontrib><creatorcontrib>KENDALL, B. E</creatorcontrib><creatorcontrib>KINGSLEY, D. P. E</creatorcontrib><creatorcontrib>MOSELEY, I. F</creatorcontrib><creatorcontrib>RUDGE, P</creatorcontrib><creatorcontrib>MCDONALD, W. I</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain (London, England : 1878)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KERMODE, A. G</au><au>THOMPSON, A. J</au><au>TOFTS, P</au><au>MACMANUS, D. G</au><au>KENDALL, B. E</au><au>KINGSLEY, D. P. 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| fulltext | fulltext |
| identifier | ISSN: 0006-8950 |
| ispartof | Brain (London, England : 1878), 1990-10, Vol.113 (5), p.1477-1489 |
| issn | 0006-8950 1460-2156 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80132315 |
| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Adult Biological and medical sciences Blood-Brain Barrier Brain - pathology Contrast Media Disability Evaluation Female Gadolinium DTPA Humans Magnetic Resonance Imaging Male Medical sciences Middle Aged Multiple Sclerosis - diagnosis Multiple Sclerosis - metabolism Multiple Sclerosis - physiopathology Neurology Organometallic Compounds Pentetic Acid |
| title | Breakdown of the blood-brain barrier precedes symptoms and other MRI signs of new lesions in multiple sclerosis : pathogenetic and clinical implications |
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