Small-molecule antagonists of the oncogenic Tcf/β-catenin protein complex

Key molecular lesions in colorectal and other cancers cause β-catenin-dependent transactivation of T cell factor (Tcf)-dependent genes. Disruption of this signal represents an opportunity for rational cancer therapy. To identify compounds that inhibit association between Tcf4 and β-catenin, we scree...

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Veröffentlicht in:	Cancer cell 2004, Vol.5 (1), p.91-102
Hauptverfasser:	Lepourcelet, Maina, Chen, Ying-Nan P., France, Dennis S., Wang, Huisheng, Crews, Phillip, Petersen, Frank, Bruseo, Charles, Wood, Alexander W., Shivdasani, Ramesh A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta Catenin Cell Division - physiology Cercopithecus aethiops Combinatorial Chemistry Techniques COS Cells Cyclin D1 - metabolism Cytoskeletal Proteins - metabolism DNA-Binding Proteins - metabolism Protein Binding Signal Transduction - physiology Surface Plasmon Resonance Trans-Activators - metabolism Transcription Factors - metabolism Xenopus Xenopus - metabolism Xenopus Proteins
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