Regulation of inosine monophosphate dehydrogenase type I and type II isoforms in human lymphocytes

The enzyme inosine monophosphate dehydrogenase (IMPDH) catalyzes the rate-limiting step in the de novo biosynthesis of guanine nucleotides. Inhibition of IMPDH leads to immunosuppression by decreasing guanine nucleotides that are required for the proliferation of lymphocytes. IMPDH activity is media...

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Veröffentlicht in:	Biochemical pharmacology 2004-02, Vol.67 (4), p.767-776
Hauptverfasser:	Jain, Jugnu, Almquist, Susan J., Ford, Pamella J., Shlyakhter, Dina, Wang, Yongping, Nimmesgern, Elmar, Germann, Ursula A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Carbamates - pharmacology Enzyme Inhibitors - pharmacology Gene regulation Humans Immune IMP Dehydrogenase - antagonists & inhibitors IMP Dehydrogenase - genetics IMP Dehydrogenase - metabolism IMPDH Isoenzymes - genetics Isoenzymes - metabolism Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - enzymology Lymphocytes Lymphocytes - enzymology Medical sciences Mycophenolic acid Mycophenolic Acid - pharmacology Pharmacology. Drug treatments Phenylurea Compounds - pharmacology RNA, Messenger - metabolism Tumor Cells, Cultured VX-497
Online-Zugang:	Volltext
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