Differential effects of sex steroids on uterine and renal ODC activity in ovariectomized rats
Many hormones are known to induce the activity of ornithine decarboxylase (ODC), the first and rate-limiting enzyme for polyamine biosynthesis, in their target tissues. Using ovariectomized rats, we have compared the effects of sex hormones on ODC activity in the uterus and the kidney which contain...
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| Veröffentlicht in: | Life sciences (1973) 1990, Vol.47 (14), p.1261-1267 |
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| container_title | Life sciences (1973) |
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| creator | Wing, Lih-Yuh C. |
| description | Many hormones are known to induce the activity of ornithine decarboxylase (ODC), the first and rate-limiting enzyme for polyamine biosynthesis, in their target tissues. Using ovariectomized rats, we have compared the effects of sex hormones on ODC activity in the uterus and the kidney which contain estrogen and androgen receptors. The results show that 1) both estrogen and androgen stimulate renal ODC activity, 2) estrogen but not androgen effectively increases ODC activity in the uterus, 3) estrogen at higher dosage can stimulate renal ODC activity to an extent similar to that in the uterus, 4) daily treatment with estradiol for 5 days results in the desensitization of uterine ODC activity, but not that of renal ODC activity to the hormonal stimuli. Although both uterus and kidney are targets of sex hormones, our results indicate that estrogen and androgen have differential influences on the ODC activity in these two organs. |
| doi_str_mv | 10.1016/0024-3205(90)90219-H |
| format | Article |
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Using ovariectomized rats, we have compared the effects of sex hormones on ODC activity in the uterus and the kidney which contain estrogen and androgen receptors. The results show that 1) both estrogen and androgen stimulate renal ODC activity, 2) estrogen but not androgen effectively increases ODC activity in the uterus, 3) estrogen at higher dosage can stimulate renal ODC activity to an extent similar to that in the uterus, 4) daily treatment with estradiol for 5 days results in the desensitization of uterine ODC activity, but not that of renal ODC activity to the hormonal stimuli. Although both uterus and kidney are targets of sex hormones, our results indicate that estrogen and androgen have differential influences on the ODC activity in these two organs.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/0024-3205(90)90219-H</identifier><identifier>PMID: 2243540</identifier><identifier>CODEN: LIFSAK</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Androgens - physiology ; Animals ; Biogenic Polyamines - metabolism ; Biological and medical sciences ; Estrogens - physiology ; Female ; Fundamental and applied biological sciences. Psychology ; Kidney - enzymology ; Ornithine Decarboxylase - metabolism ; Ovariectomy ; Rats ; Rats, Inbred Strains ; Steroid hormones. 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Using ovariectomized rats, we have compared the effects of sex hormones on ODC activity in the uterus and the kidney which contain estrogen and androgen receptors. The results show that 1) both estrogen and androgen stimulate renal ODC activity, 2) estrogen but not androgen effectively increases ODC activity in the uterus, 3) estrogen at higher dosage can stimulate renal ODC activity to an extent similar to that in the uterus, 4) daily treatment with estradiol for 5 days results in the desensitization of uterine ODC activity, but not that of renal ODC activity to the hormonal stimuli. Although both uterus and kidney are targets of sex hormones, our results indicate that estrogen and androgen have differential influences on the ODC activity in these two organs.</description><subject>Androgens - physiology</subject><subject>Animals</subject><subject>Biogenic Polyamines - metabolism</subject><subject>Biological and medical sciences</subject><subject>Estrogens - physiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Kidney - enzymology</subject><subject>Ornithine Decarboxylase - metabolism</subject><subject>Ovariectomy</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Steroid hormones. 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Psychology</topic><topic>Kidney - enzymology</topic><topic>Ornithine Decarboxylase - metabolism</topic><topic>Ovariectomy</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Steroid hormones. Cholecalciferol derivatives</topic><topic>Uterus - enzymology</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wing, Lih-Yuh C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wing, Lih-Yuh C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential effects of sex steroids on uterine and renal ODC activity in ovariectomized rats</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1990</date><risdate>1990</risdate><volume>47</volume><issue>14</issue><spage>1261</spage><epage>1267</epage><pages>1261-1267</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><coden>LIFSAK</coden><abstract>Many hormones are known to induce the activity of ornithine decarboxylase (ODC), the first and rate-limiting enzyme for polyamine biosynthesis, in their target tissues. Using ovariectomized rats, we have compared the effects of sex hormones on ODC activity in the uterus and the kidney which contain estrogen and androgen receptors. The results show that 1) both estrogen and androgen stimulate renal ODC activity, 2) estrogen but not androgen effectively increases ODC activity in the uterus, 3) estrogen at higher dosage can stimulate renal ODC activity to an extent similar to that in the uterus, 4) daily treatment with estradiol for 5 days results in the desensitization of uterine ODC activity, but not that of renal ODC activity to the hormonal stimuli. Although both uterus and kidney are targets of sex hormones, our results indicate that estrogen and androgen have differential influences on the ODC activity in these two organs.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>2243540</pmid><doi>10.1016/0024-3205(90)90219-H</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Life sciences (1973), 1990, Vol.47 (14), p.1261-1267 |
| issn | 0024-3205 1879-0631 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Androgens - physiology Animals Biogenic Polyamines - metabolism Biological and medical sciences Estrogens - physiology Female Fundamental and applied biological sciences. Psychology Kidney - enzymology Ornithine Decarboxylase - metabolism Ovariectomy Rats Rats, Inbred Strains Steroid hormones. Cholecalciferol derivatives Uterus - enzymology Vertebrates: endocrinology |
| title | Differential effects of sex steroids on uterine and renal ODC activity in ovariectomized rats |
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