Differences in memory performance and other clinical characteristics in patients with mesial temporal lobe epilepsy with and without hippocampal atrophy
Mesial temporal lobe epilepsy (MTLE) is usually accompanied by memory deficits due to damage to the hippocampal system. In most studies, however, the influence of hippocampal atrophy (HA) is confounded with other variables, such as: type of initial precipitating injury and pathological substrate, ef...
Gespeichert in:
| Veröffentlicht in: | Epilepsy & behavior 2004-02, Vol.5 (1), p.22-27 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 27 |
|---|---|
| container_issue | 1 |
| container_start_page | 22 |
| container_title | Epilepsy & behavior |
| container_volume | 5 |
| creator | Alessio, A. Damasceno, B.P. Camargo, C.H.P. Kobayashi, E. Guerreiro, C.A.M. Cendes, F. |
| description | Mesial temporal lobe epilepsy (MTLE) is usually accompanied by memory deficits due to damage to the hippocampal system. In most studies, however, the influence of hippocampal atrophy (HA) is confounded with other variables, such as: type of initial precipitating injury and pathological substrate, effect of lesion (HA) lateralization, history of febrile seizures, status epilepticus, age of seizure onset, duration of epilepsy, seizure frequency, and antiepileptic drugs (AEDs). To investigate the relationship between memory deficits and these variables, we studied 20 patients with MTLE and signs of HA on MRI and 15 MTLE patients with normal high-resolution MRI. The findings indicated that (1) HA, earlier onset of seizures, longer duration of epilepsy, higher seizure frequency, and AEDs (polytherapy) are associated with memory deficits; and (2) there is a close relationship between deficits of verbal memory and left HA, but not between visual memory and right HA. |
| doi_str_mv | 10.1016/j.yebeh.2003.10.010 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80128056</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1525505003002993</els_id><sourcerecordid>80128056</sourcerecordid><originalsourceid>FETCH-LOGICAL-c355t-e40454d1df8bd0706eb118aed3ebf825d5a0e76eebd4372c50cc827b8f919d9a3</originalsourceid><addsrcrecordid>eNp9kc1q3DAUhUVJadIkT1AoWmU30yvbsj2LLEr6C4Fu2rWQpWt8B9tSJE2D36SPWzkzJLusdDh854jLYeyDgK0AUX_abxfscNgWAGV2tiDgDbsQspAbCfXu7FlLOGfvY9wDCCFL8Y6di6qRooDigv37Qn2PAWeDkdPMJ5xcWLjH0Lsw6WxzPVvu0oCBm5FmMnrkZtBBm4SBYiLzFPQ6Ec4p8kdKQ66JlLmEk3chi9F1yNHTiD4uR2StXYU7JD6Q987oyWdUp-D8sFyxt70eI16f3kv259vX33c_Nve_vv-8-3y_MaWUaYMVVLKywvZtZ6GBGjshWo22xK5vC2mlBmxqxM5WZVMYCca0RdO1_U7s7E6Xl-zm2OuDezhgTGqiaHAc9YzuEFULomhB1hksj6AJLsaAvfKBJh0WJUCtg6i9ehpErYOsZh4kpz6e6g_dhPYlc1ogA7dHAPORfwmDiobWOSwFNElZR69-8B9u9aI-</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>80128056</pqid></control><display><type>article</type><title>Differences in memory performance and other clinical characteristics in patients with mesial temporal lobe epilepsy with and without hippocampal atrophy</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Alessio, A. ; Damasceno, B.P. ; Camargo, C.H.P. ; Kobayashi, E. ; Guerreiro, C.A.M. ; Cendes, F.</creator><creatorcontrib>Alessio, A. ; Damasceno, B.P. ; Camargo, C.H.P. ; Kobayashi, E. ; Guerreiro, C.A.M. ; Cendes, F.</creatorcontrib><description>Mesial temporal lobe epilepsy (MTLE) is usually accompanied by memory deficits due to damage to the hippocampal system. In most studies, however, the influence of hippocampal atrophy (HA) is confounded with other variables, such as: type of initial precipitating injury and pathological substrate, effect of lesion (HA) lateralization, history of febrile seizures, status epilepticus, age of seizure onset, duration of epilepsy, seizure frequency, and antiepileptic drugs (AEDs). To investigate the relationship between memory deficits and these variables, we studied 20 patients with MTLE and signs of HA on MRI and 15 MTLE patients with normal high-resolution MRI. The findings indicated that (1) HA, earlier onset of seizures, longer duration of epilepsy, higher seizure frequency, and AEDs (polytherapy) are associated with memory deficits; and (2) there is a close relationship between deficits of verbal memory and left HA, but not between visual memory and right HA.</description><identifier>ISSN: 1525-5050</identifier><identifier>EISSN: 1525-5069</identifier><identifier>DOI: 10.1016/j.yebeh.2003.10.010</identifier><identifier>PMID: 14751202</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Anticonvulsants - therapeutic use ; Antiepileptic drugs ; Atrophy - pathology ; Atrophy - physiopathology ; Duration of epilepsy ; Electroencephalography ; Epilepsy, Temporal Lobe - pathology ; Epilepsy, Temporal Lobe - physiopathology ; Febrile seizures ; Female ; Functional Laterality ; Hippocampal atrophy ; Hippocampus - pathology ; Humans ; Intelligence - physiology ; Intelligence Tests - statistics & numerical data ; Magnetic Resonance Imaging ; Male ; Memory - physiology ; Memory deficits ; Mesial temporal lobe epilepsy ; Middle Aged ; Neuropsychological evaluation ; Neuropsychological Tests - statistics & numerical data ; Seizure frequency ; Seizure onset ; Seizures, Febrile - physiopathology ; Status epilepticus ; Status Epilepticus - drug therapy ; Status Epilepticus - physiopathology</subject><ispartof>Epilepsy & behavior, 2004-02, Vol.5 (1), p.22-27</ispartof><rights>2003 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c355t-e40454d1df8bd0706eb118aed3ebf825d5a0e76eebd4372c50cc827b8f919d9a3</citedby><cites>FETCH-LOGICAL-c355t-e40454d1df8bd0706eb118aed3ebf825d5a0e76eebd4372c50cc827b8f919d9a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1525505003002993$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14751202$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alessio, A.</creatorcontrib><creatorcontrib>Damasceno, B.P.</creatorcontrib><creatorcontrib>Camargo, C.H.P.</creatorcontrib><creatorcontrib>Kobayashi, E.</creatorcontrib><creatorcontrib>Guerreiro, C.A.M.</creatorcontrib><creatorcontrib>Cendes, F.</creatorcontrib><title>Differences in memory performance and other clinical characteristics in patients with mesial temporal lobe epilepsy with and without hippocampal atrophy</title><title>Epilepsy & behavior</title><addtitle>Epilepsy Behav</addtitle><description>Mesial temporal lobe epilepsy (MTLE) is usually accompanied by memory deficits due to damage to the hippocampal system. In most studies, however, the influence of hippocampal atrophy (HA) is confounded with other variables, such as: type of initial precipitating injury and pathological substrate, effect of lesion (HA) lateralization, history of febrile seizures, status epilepticus, age of seizure onset, duration of epilepsy, seizure frequency, and antiepileptic drugs (AEDs). To investigate the relationship between memory deficits and these variables, we studied 20 patients with MTLE and signs of HA on MRI and 15 MTLE patients with normal high-resolution MRI. The findings indicated that (1) HA, earlier onset of seizures, longer duration of epilepsy, higher seizure frequency, and AEDs (polytherapy) are associated with memory deficits; and (2) there is a close relationship between deficits of verbal memory and left HA, but not between visual memory and right HA.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anticonvulsants - therapeutic use</subject><subject>Antiepileptic drugs</subject><subject>Atrophy - pathology</subject><subject>Atrophy - physiopathology</subject><subject>Duration of epilepsy</subject><subject>Electroencephalography</subject><subject>Epilepsy, Temporal Lobe - pathology</subject><subject>Epilepsy, Temporal Lobe - physiopathology</subject><subject>Febrile seizures</subject><subject>Female</subject><subject>Functional Laterality</subject><subject>Hippocampal atrophy</subject><subject>Hippocampus - pathology</subject><subject>Humans</subject><subject>Intelligence - physiology</subject><subject>Intelligence Tests - statistics & numerical data</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Memory - physiology</subject><subject>Memory deficits</subject><subject>Mesial temporal lobe epilepsy</subject><subject>Middle Aged</subject><subject>Neuropsychological evaluation</subject><subject>Neuropsychological Tests - statistics & numerical data</subject><subject>Seizure frequency</subject><subject>Seizure onset</subject><subject>Seizures, Febrile - physiopathology</subject><subject>Status epilepticus</subject><subject>Status Epilepticus - drug therapy</subject><subject>Status Epilepticus - physiopathology</subject><issn>1525-5050</issn><issn>1525-5069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1q3DAUhUVJadIkT1AoWmU30yvbsj2LLEr6C4Fu2rWQpWt8B9tSJE2D36SPWzkzJLusdDh854jLYeyDgK0AUX_abxfscNgWAGV2tiDgDbsQspAbCfXu7FlLOGfvY9wDCCFL8Y6di6qRooDigv37Qn2PAWeDkdPMJ5xcWLjH0Lsw6WxzPVvu0oCBm5FmMnrkZtBBm4SBYiLzFPQ6Ec4p8kdKQ66JlLmEk3chi9F1yNHTiD4uR2StXYU7JD6Q987oyWdUp-D8sFyxt70eI16f3kv259vX33c_Nve_vv-8-3y_MaWUaYMVVLKywvZtZ6GBGjshWo22xK5vC2mlBmxqxM5WZVMYCca0RdO1_U7s7E6Xl-zm2OuDezhgTGqiaHAc9YzuEFULomhB1hksj6AJLsaAvfKBJh0WJUCtg6i9ehpErYOsZh4kpz6e6g_dhPYlc1ogA7dHAPORfwmDiobWOSwFNElZR69-8B9u9aI-</recordid><startdate>20040201</startdate><enddate>20040201</enddate><creator>Alessio, A.</creator><creator>Damasceno, B.P.</creator><creator>Camargo, C.H.P.</creator><creator>Kobayashi, E.</creator><creator>Guerreiro, C.A.M.</creator><creator>Cendes, F.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040201</creationdate><title>Differences in memory performance and other clinical characteristics in patients with mesial temporal lobe epilepsy with and without hippocampal atrophy</title><author>Alessio, A. ; Damasceno, B.P. ; Camargo, C.H.P. ; Kobayashi, E. ; Guerreiro, C.A.M. ; Cendes, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c355t-e40454d1df8bd0706eb118aed3ebf825d5a0e76eebd4372c50cc827b8f919d9a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anticonvulsants - therapeutic use</topic><topic>Antiepileptic drugs</topic><topic>Atrophy - pathology</topic><topic>Atrophy - physiopathology</topic><topic>Duration of epilepsy</topic><topic>Electroencephalography</topic><topic>Epilepsy, Temporal Lobe - pathology</topic><topic>Epilepsy, Temporal Lobe - physiopathology</topic><topic>Febrile seizures</topic><topic>Female</topic><topic>Functional Laterality</topic><topic>Hippocampal atrophy</topic><topic>Hippocampus - pathology</topic><topic>Humans</topic><topic>Intelligence - physiology</topic><topic>Intelligence Tests - statistics & numerical data</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Memory - physiology</topic><topic>Memory deficits</topic><topic>Mesial temporal lobe epilepsy</topic><topic>Middle Aged</topic><topic>Neuropsychological evaluation</topic><topic>Neuropsychological Tests - statistics & numerical data</topic><topic>Seizure frequency</topic><topic>Seizure onset</topic><topic>Seizures, Febrile - physiopathology</topic><topic>Status epilepticus</topic><topic>Status Epilepticus - drug therapy</topic><topic>Status Epilepticus - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alessio, A.</creatorcontrib><creatorcontrib>Damasceno, B.P.</creatorcontrib><creatorcontrib>Camargo, C.H.P.</creatorcontrib><creatorcontrib>Kobayashi, E.</creatorcontrib><creatorcontrib>Guerreiro, C.A.M.</creatorcontrib><creatorcontrib>Cendes, F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Epilepsy & behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alessio, A.</au><au>Damasceno, B.P.</au><au>Camargo, C.H.P.</au><au>Kobayashi, E.</au><au>Guerreiro, C.A.M.</au><au>Cendes, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differences in memory performance and other clinical characteristics in patients with mesial temporal lobe epilepsy with and without hippocampal atrophy</atitle><jtitle>Epilepsy & behavior</jtitle><addtitle>Epilepsy Behav</addtitle><date>2004-02-01</date><risdate>2004</risdate><volume>5</volume><issue>1</issue><spage>22</spage><epage>27</epage><pages>22-27</pages><issn>1525-5050</issn><eissn>1525-5069</eissn><abstract>Mesial temporal lobe epilepsy (MTLE) is usually accompanied by memory deficits due to damage to the hippocampal system. In most studies, however, the influence of hippocampal atrophy (HA) is confounded with other variables, such as: type of initial precipitating injury and pathological substrate, effect of lesion (HA) lateralization, history of febrile seizures, status epilepticus, age of seizure onset, duration of epilepsy, seizure frequency, and antiepileptic drugs (AEDs). To investigate the relationship between memory deficits and these variables, we studied 20 patients with MTLE and signs of HA on MRI and 15 MTLE patients with normal high-resolution MRI. The findings indicated that (1) HA, earlier onset of seizures, longer duration of epilepsy, higher seizure frequency, and AEDs (polytherapy) are associated with memory deficits; and (2) there is a close relationship between deficits of verbal memory and left HA, but not between visual memory and right HA.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>14751202</pmid><doi>10.1016/j.yebeh.2003.10.010</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1525-5050 |
| ispartof | Epilepsy & behavior, 2004-02, Vol.5 (1), p.22-27 |
| issn | 1525-5050 1525-5069 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80128056 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adolescent Adult Anticonvulsants - therapeutic use Antiepileptic drugs Atrophy - pathology Atrophy - physiopathology Duration of epilepsy Electroencephalography Epilepsy, Temporal Lobe - pathology Epilepsy, Temporal Lobe - physiopathology Febrile seizures Female Functional Laterality Hippocampal atrophy Hippocampus - pathology Humans Intelligence - physiology Intelligence Tests - statistics & numerical data Magnetic Resonance Imaging Male Memory - physiology Memory deficits Mesial temporal lobe epilepsy Middle Aged Neuropsychological evaluation Neuropsychological Tests - statistics & numerical data Seizure frequency Seizure onset Seizures, Febrile - physiopathology Status epilepticus Status Epilepticus - drug therapy Status Epilepticus - physiopathology |
| title | Differences in memory performance and other clinical characteristics in patients with mesial temporal lobe epilepsy with and without hippocampal atrophy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T06%3A02%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Differences%20in%20memory%20performance%20and%20other%20clinical%20characteristics%20in%20patients%20with%20mesial%20temporal%20lobe%20epilepsy%20with%20and%20without%20hippocampal%20atrophy&rft.jtitle=Epilepsy%20&%20behavior&rft.au=Alessio,%20A.&rft.date=2004-02-01&rft.volume=5&rft.issue=1&rft.spage=22&rft.epage=27&rft.pages=22-27&rft.issn=1525-5050&rft.eissn=1525-5069&rft_id=info:doi/10.1016/j.yebeh.2003.10.010&rft_dat=%3Cproquest_cross%3E80128056%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=80128056&rft_id=info:pmid/14751202&rft_els_id=S1525505003002993&rfr_iscdi=true |