Anti-inflammatory glucocorticoids inhibit the induction by endotoxin of nitric oxide synthase in the lung, liver and aorta of the rat
The induction by endotoxin of Ca 2+-independent nitric oxide (NO) synthase in the lung and liver of the rat was prevented by the glucocorticoids dexamethasone and cortisol but not by progesterone. The activity of the constitutive Ca 2+-dependent NO synthase in the brain and the aorta was not affecte...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1990-11, Vol.172 (3), p.1042-1048 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Knowles, R.G. Salter, M. Brooks, S.L. Moncada, S. |
| description | The induction by endotoxin of Ca
2+-independent nitric oxide (NO) synthase in the lung and liver of the rat was prevented by the glucocorticoids dexamethasone and cortisol but not by progesterone. The activity of the constitutive Ca
2+-dependent NO synthase in the brain and the aorta was not affected by treatment with either endotoxin or glucocorticoids. In the aorta a Ca
2+-independent NO synthase was also found following endotoxin treatment of rats, and this induction was likewise prevented by dexamethasone. The Ca
2+-dependent NO synthase in the aorta was located in the vascular endothelium, whereas the Ca
2+-independent enzyme was predominantly located in the vascular smooth muscle layer. Inhibition of induction of the Ca
2+-independent NO synthase
in vivo
may underlie some of the physiological and pharmacological effects of the anti-inflammatory glucocorticoids. |
| doi_str_mv | 10.1016/0006-291X(90)91551-3 |
| format | Article |
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2+-independent nitric oxide (NO) synthase in the lung and liver of the rat was prevented by the glucocorticoids dexamethasone and cortisol but not by progesterone. The activity of the constitutive Ca
2+-dependent NO synthase in the brain and the aorta was not affected by treatment with either endotoxin or glucocorticoids. In the aorta a Ca
2+-independent NO synthase was also found following endotoxin treatment of rats, and this induction was likewise prevented by dexamethasone. The Ca
2+-dependent NO synthase in the aorta was located in the vascular endothelium, whereas the Ca
2+-independent enzyme was predominantly located in the vascular smooth muscle layer. Inhibition of induction of the Ca
2+-independent NO synthase
in vivo
may underlie some of the physiological and pharmacological effects of the anti-inflammatory glucocorticoids.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/0006-291X(90)91551-3</identifier><identifier>PMID: 1700903</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Amino Acid Oxidoreductases - biosynthesis ; Animals ; Anti-Inflammatory Agents - pharmacology ; Aorta - drug effects ; Aorta - enzymology ; Dexamethasone - pharmacology ; Endotoxins - pharmacology ; Enzyme Induction - drug effects ; Glucocorticoids - pharmacology ; Hydrocortisone - pharmacology ; Liver - drug effects ; Liver - enzymology ; Lung - drug effects ; Lung - enzymology ; Male ; Nitric Oxide Synthase ; Progesterone - pharmacology ; Rats ; Rats, Inbred Strains</subject><ispartof>Biochemical and biophysical research communications, 1990-11, Vol.172 (3), p.1042-1048</ispartof><rights>1990</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c338t-f03ed23f35bbde0b392b97e35256fd2261b0b98fd2f736667f601a1c9436fefd3</citedby><cites>FETCH-LOGICAL-c338t-f03ed23f35bbde0b392b97e35256fd2261b0b98fd2f736667f601a1c9436fefd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-291X(90)91551-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1700903$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Knowles, R.G.</creatorcontrib><creatorcontrib>Salter, M.</creatorcontrib><creatorcontrib>Brooks, S.L.</creatorcontrib><creatorcontrib>Moncada, S.</creatorcontrib><title>Anti-inflammatory glucocorticoids inhibit the induction by endotoxin of nitric oxide synthase in the lung, liver and aorta of the rat</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>The induction by endotoxin of Ca
2+-independent nitric oxide (NO) synthase in the lung and liver of the rat was prevented by the glucocorticoids dexamethasone and cortisol but not by progesterone. The activity of the constitutive Ca
2+-dependent NO synthase in the brain and the aorta was not affected by treatment with either endotoxin or glucocorticoids. In the aorta a Ca
2+-independent NO synthase was also found following endotoxin treatment of rats, and this induction was likewise prevented by dexamethasone. The Ca
2+-dependent NO synthase in the aorta was located in the vascular endothelium, whereas the Ca
2+-independent enzyme was predominantly located in the vascular smooth muscle layer. Inhibition of induction of the Ca
2+-independent NO synthase
in vivo
may underlie some of the physiological and pharmacological effects of the anti-inflammatory glucocorticoids.</description><subject>Amino Acid Oxidoreductases - biosynthesis</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Aorta - drug effects</subject><subject>Aorta - enzymology</subject><subject>Dexamethasone - pharmacology</subject><subject>Endotoxins - pharmacology</subject><subject>Enzyme Induction - drug effects</subject><subject>Glucocorticoids - pharmacology</subject><subject>Hydrocortisone - pharmacology</subject><subject>Liver - drug effects</subject><subject>Liver - enzymology</subject><subject>Lung - drug effects</subject><subject>Lung - enzymology</subject><subject>Male</subject><subject>Nitric Oxide Synthase</subject><subject>Progesterone - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kN1qFTEUhYMo9bT6Bgq5EguO7kzOZE5uCqX4BwVvFLwL-dnpicwkNckUzwP43mZ6it55tfdmfWuFLEJeMHjLgIl3ACC6XrLvryWcSzYMrOOPyIaBhK5nsH1MNn-Rp-S0lB8AjG2FPCEnbISG8Q35fRlr6EL0k55nXVM-0JtpscmmXINNwRUa4j6YUGndY9vdYmtIkZoDxehSTb9CpMnTGGoOlrbTIS2HWPe6rPy9bVrizRs6hTvMVEdHdUvXq2sVs67PyBOvp4LPH-YZ-fbh_derT931l4-fry6vO8v5rnYeOLqeez4Y4xAMl72RI_KhH4R3fS-YASN3bfUjF0KMXgDTzMotFx6942fk1TH3NqefC5aq5lAsTpOOmJaidsD6sZdDA7dH0OZUSkavbnOYdT4oBmptX63VqrVaJUHdt694s718yF_MjO6f6Vh30y-OOrZP3gXMqtiA0aILGW1VLoX_P_AHZKKWkw</recordid><startdate>19901115</startdate><enddate>19901115</enddate><creator>Knowles, R.G.</creator><creator>Salter, M.</creator><creator>Brooks, S.L.</creator><creator>Moncada, S.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19901115</creationdate><title>Anti-inflammatory glucocorticoids inhibit the induction by endotoxin of nitric oxide synthase in the lung, liver and aorta of the rat</title><author>Knowles, R.G. ; Salter, M. ; Brooks, S.L. ; Moncada, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-f03ed23f35bbde0b392b97e35256fd2261b0b98fd2f736667f601a1c9436fefd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Amino Acid Oxidoreductases - biosynthesis</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Aorta - drug effects</topic><topic>Aorta - enzymology</topic><topic>Dexamethasone - pharmacology</topic><topic>Endotoxins - pharmacology</topic><topic>Enzyme Induction - drug effects</topic><topic>Glucocorticoids - pharmacology</topic><topic>Hydrocortisone - pharmacology</topic><topic>Liver - drug effects</topic><topic>Liver - enzymology</topic><topic>Lung - drug effects</topic><topic>Lung - enzymology</topic><topic>Male</topic><topic>Nitric Oxide Synthase</topic><topic>Progesterone - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Knowles, R.G.</creatorcontrib><creatorcontrib>Salter, M.</creatorcontrib><creatorcontrib>Brooks, S.L.</creatorcontrib><creatorcontrib>Moncada, S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Knowles, R.G.</au><au>Salter, M.</au><au>Brooks, S.L.</au><au>Moncada, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-inflammatory glucocorticoids inhibit the induction by endotoxin of nitric oxide synthase in the lung, liver and aorta of the rat</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1990-11-15</date><risdate>1990</risdate><volume>172</volume><issue>3</issue><spage>1042</spage><epage>1048</epage><pages>1042-1048</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>The induction by endotoxin of Ca
2+-independent nitric oxide (NO) synthase in the lung and liver of the rat was prevented by the glucocorticoids dexamethasone and cortisol but not by progesterone. The activity of the constitutive Ca
2+-dependent NO synthase in the brain and the aorta was not affected by treatment with either endotoxin or glucocorticoids. In the aorta a Ca
2+-independent NO synthase was also found following endotoxin treatment of rats, and this induction was likewise prevented by dexamethasone. The Ca
2+-dependent NO synthase in the aorta was located in the vascular endothelium, whereas the Ca
2+-independent enzyme was predominantly located in the vascular smooth muscle layer. Inhibition of induction of the Ca
2+-independent NO synthase
in vivo
may underlie some of the physiological and pharmacological effects of the anti-inflammatory glucocorticoids.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>1700903</pmid><doi>10.1016/0006-291X(90)91551-3</doi><tpages>7</tpages></addata></record> |
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| ispartof | Biochemical and biophysical research communications, 1990-11, Vol.172 (3), p.1042-1048 |
| issn | 0006-291X 1090-2104 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amino Acid Oxidoreductases - biosynthesis Animals Anti-Inflammatory Agents - pharmacology Aorta - drug effects Aorta - enzymology Dexamethasone - pharmacology Endotoxins - pharmacology Enzyme Induction - drug effects Glucocorticoids - pharmacology Hydrocortisone - pharmacology Liver - drug effects Liver - enzymology Lung - drug effects Lung - enzymology Male Nitric Oxide Synthase Progesterone - pharmacology Rats Rats, Inbred Strains |
| title | Anti-inflammatory glucocorticoids inhibit the induction by endotoxin of nitric oxide synthase in the lung, liver and aorta of the rat |
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