Isolation and puriﬁcation of the hypoglycaemic principle present in Capsicum frutescens

Capsicum frutescens has been used to treat diabetes mellitus by traditional healers in Jamaica. Puriﬁcation experiments employing thin layer chromatography (TLC) and high performance liquid chromatography led to the extraction of the active principle, capsaicin. Puriﬁed capsaicin caused a decrease i...

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Veröffentlicht in:	Phytotherapy research 2004-01, Vol.18 (1), p.95-96
Hauptverfasser:	Tolan, Ian, Ragoobirsingh, Dalip, Morrison, Errol Y. St. A.
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Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Glucose - drug effects capsaicin Capsaicin - administration & dosage Capsaicin - chemistry Capsaicin - pharmacology Capsaicin - therapeutic use Capsicum Chromatography Chromatography, High Pressure Liquid Diabetes Mellitus, Experimental - prevention & control Disease Models, Animal Dogs General pharmacology hypoglycaemia Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - chemistry Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use Insulin - blood isolation Jamaica Medical sciences pepper Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts - administration & dosage Plant Extracts - chemistry Plant Extracts - pharmacology Plant Extracts - therapeutic use puriﬁcation
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description	Capsicum frutescens has been used to treat diabetes mellitus by traditional healers in Jamaica. Puriﬁcation experiments employing thin layer chromatography (TLC) and high performance liquid chromatography led to the extraction of the active principle, capsaicin. Puriﬁed capsaicin caused a decrease in blood glucose levels to 4.91 ± 0.52 (n = 6) mmol/dL versus 6.40 ± 0.13 mmol/dL (n = 6) for the control (p < 0.05) at 2.5 h in an OGTT in dogs. There was a concomitant elevation in plasma insulin levels (p < 0.05). In conclusion, it can be stated that capsaicin is the major constituent of Capsicum frutescens that is responsible for the hypoglycaemic episodes seen in the dogs. It is also apparent that the latter is mediated by insulin release. Copyright © 2004 John Wiley & Sons, Ltd.
doi_str_mv	10.1002/ptr.1328
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St. A.</creator><creatorcontrib>Tolan, Ian ; Ragoobirsingh, Dalip ; Morrison, Errol Y. St. A.</creatorcontrib><description>Capsicum frutescens has been used to treat diabetes mellitus by traditional healers in Jamaica. Puriﬁcation experiments employing thin layer chromatography (TLC) and high performance liquid chromatography led to the extraction of the active principle, capsaicin. Puriﬁed capsaicin caused a decrease in blood glucose levels to 4.91 ± 0.52 (n = 6) mmol/dL versus 6.40 ± 0.13 mmol/dL (n = 6) for the control (p < 0.05) at 2.5 h in an OGTT in dogs. There was a concomitant elevation in plasma insulin levels (p < 0.05). In conclusion, it can be stated that capsaicin is the major constituent of Capsicum frutescens that is responsible for the hypoglycaemic episodes seen in the dogs. It is also apparent that the latter is mediated by insulin release. Copyright © 2004 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.1328</identifier><identifier>PMID: 14750210</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Animals ; Biological and medical sciences ; Blood Glucose - drug effects ; capsaicin ; Capsaicin - administration & dosage ; Capsaicin - chemistry ; Capsaicin - pharmacology ; Capsaicin - therapeutic use ; Capsicum ; Chromatography ; Chromatography, High Pressure Liquid ; Diabetes Mellitus, Experimental - prevention & control ; Disease Models, Animal ; Dogs ; General pharmacology ; hypoglycaemia ; Hypoglycemic Agents - administration & dosage ; Hypoglycemic Agents - chemistry ; Hypoglycemic Agents - pharmacology ; Hypoglycemic Agents - therapeutic use ; Insulin - blood ; isolation ; Jamaica ; Medical sciences ; pepper ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. 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St. A.</creatorcontrib><title>Isolation and puriﬁcation of the hypoglycaemic principle present in Capsicum frutescens</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>Capsicum frutescens has been used to treat diabetes mellitus by traditional healers in Jamaica. Puriﬁcation experiments employing thin layer chromatography (TLC) and high performance liquid chromatography led to the extraction of the active principle, capsaicin. Puriﬁed capsaicin caused a decrease in blood glucose levels to 4.91 ± 0.52 (n = 6) mmol/dL versus 6.40 ± 0.13 mmol/dL (n = 6) for the control (p < 0.05) at 2.5 h in an OGTT in dogs. There was a concomitant elevation in plasma insulin levels (p < 0.05). In conclusion, it can be stated that capsaicin is the major constituent of Capsicum frutescens that is responsible for the hypoglycaemic episodes seen in the dogs. It is also apparent that the latter is mediated by insulin release. Copyright © 2004 John Wiley & Sons, Ltd.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - drug effects</subject><subject>capsaicin</subject><subject>Capsaicin - administration & dosage</subject><subject>Capsaicin - chemistry</subject><subject>Capsaicin - pharmacology</subject><subject>Capsaicin - therapeutic use</subject><subject>Capsicum</subject><subject>Chromatography</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Diabetes Mellitus, Experimental - prevention & control</subject><subject>Disease Models, Animal</subject><subject>Dogs</subject><subject>General pharmacology</subject><subject>hypoglycaemia</subject><subject>Hypoglycemic Agents - administration & dosage</subject><subject>Hypoglycemic Agents - chemistry</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Insulin - blood</subject><subject>isolation</subject><subject>Jamaica</subject><subject>Medical sciences</subject><subject>pepper</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phytotherapy</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>puriﬁcation</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10MtKxDAUBuAgio4X8AmkG8VNNZdJmy5l0PGGiijqKqTpiUZ7M2nRWfo-vpuvYGSKriSLE8KXc5IfoU2C9wjGdL_t3B5hVCygEcFZFhOeskU0whkn8ZiI-xW06v0zxjijeLyMVsg45ZgSPEIPJ74pVWebOlJ1EbW9s1-fH3p-0pioe4LoadY2j-VMK6isjlpna23bEsIOPNRdZOtoolpvdV9FxvUdeA21X0dLRpUeNoa6hm6PDm8mx_H55fRkcnAeaya4iHPFRZELk5CEJ3khCkJpnlJmRF5oTTBJcFgiVGq0YTQF0BnOgeq0SCgBtoZ25n1b17z24DtZ2fCAslQ1NL2X4SpNiaAB7s6hdo33DowMX6mUm0mC5U-MMsQof2IMdGvo2ecVFH9wyC2A7QEor1VpnAqZ-D_HBRNJlgQXz92bLWH270B5dXM9DB689R28_3rlXmSSspTLu4upzKaZOL3iR_KMfQPwmJoA</recordid><startdate>200401</startdate><enddate>200401</enddate><creator>Tolan, Ian</creator><creator>Ragoobirsingh, Dalip</creator><creator>Morrison, Errol Y. 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St. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3858-ba58db8f61656bd8d122b723f8bdcc1016060680162fcf327eec90be2c7d621e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - drug effects</topic><topic>capsaicin</topic><topic>Capsaicin - administration & dosage</topic><topic>Capsaicin - chemistry</topic><topic>Capsaicin - pharmacology</topic><topic>Capsaicin - therapeutic use</topic><topic>Capsicum</topic><topic>Chromatography</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Diabetes Mellitus, Experimental - prevention & control</topic><topic>Disease Models, Animal</topic><topic>Dogs</topic><topic>General pharmacology</topic><topic>hypoglycaemia</topic><topic>Hypoglycemic Agents - administration & dosage</topic><topic>Hypoglycemic Agents - chemistry</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Insulin - blood</topic><topic>isolation</topic><topic>Jamaica</topic><topic>Medical sciences</topic><topic>pepper</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Phytotherapy</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>puriﬁcation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tolan, Ian</creatorcontrib><creatorcontrib>Ragoobirsingh, Dalip</creatorcontrib><creatorcontrib>Morrison, Errol Y. 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subjects	Animals Biological and medical sciences Blood Glucose - drug effects capsaicin Capsaicin - administration & dosage Capsaicin - chemistry Capsaicin - pharmacology Capsaicin - therapeutic use Capsicum Chromatography Chromatography, High Pressure Liquid Diabetes Mellitus, Experimental - prevention & control Disease Models, Animal Dogs General pharmacology hypoglycaemia Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - chemistry Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use Insulin - blood isolation Jamaica Medical sciences pepper Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts - administration & dosage Plant Extracts - chemistry Plant Extracts - pharmacology Plant Extracts - therapeutic use puriﬁcation
title	Isolation and puriﬁcation of the hypoglycaemic principle present in Capsicum frutescens
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