The effect of medicinal plants of Islamabad and Murree region of Pakistan on insulin secretion from INS-1 cells
In vitro testing of the extracts of medicinal plants collected from Islamabad and the Murree region on insulin secretagogue activity was carried out. Dried ethanol extracts of all plants (ZH1‐ZH19) were dissolved in ethanol and DMSO, and tested at various concentrations (between 1 and 40 µg/mL) for...
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| Veröffentlicht in: | Phytotherapy research 2004-01, Vol.18 (1), p.73-77 |
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| container_title | Phytotherapy research |
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| creator | Hussain, Zakir Waheed, Abdul Qureshi, Rizwana Aleem Burdi, Dadu Khan Verspohl, Eugen J. Khan, Naeema Hasan, Mashooda |
| description | In vitro testing of the extracts of medicinal plants collected from Islamabad and the Murree region on insulin secretagogue activity was carried out. Dried ethanol extracts of all plants (ZH1‐ZH19) were dissolved in ethanol and DMSO, and tested at various concentrations (between 1 and 40 µg/mL) for insulin release from INS‐1 cells in the presence of 5.5 mM glucose. Glibenclamide was used as a control. Promising insulin secretagogue activity in various plant extracts at 1, 10, 20 and 40 µg/mL was found, while in some cases a decrease in insulin secretion was also observed. Artemisia roxburghiana, Salvia coccinia and Monstera deliciosa showed insulin secretagogue activity at 1 µg/mL (p < 0.05) while Abies pindrow, Centaurea iberica and Euphorbia helioscopia were active at 10 µg/mL (p < 0.05). Extracts of Bauhinia variegata and Bergenia himalacia showed effects at 20 µg/mL (p < 0.05), and Taraxacum officinale and Viburnum foetens at 40 µg/mL (p < 0.05). Insulin secretagogue activity could not be detected in the extracts of Adhatoda vasica, Cassia fistula, Chrysanthemum leucanthemum, Morus alba, Plectranthus rugosus, Peganum harmala and Olea ferruginea. The results suggest that medicinal plants of Islamabad and the Murree region of Pakistan may be potential natural resources for antidiabetic compounds. Copyright © 2004 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/ptr.1372 |
| format | Article |
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Dried ethanol extracts of all plants (ZH1‐ZH19) were dissolved in ethanol and DMSO, and tested at various concentrations (between 1 and 40 µg/mL) for insulin release from INS‐1 cells in the presence of 5.5 mM glucose. Glibenclamide was used as a control. Promising insulin secretagogue activity in various plant extracts at 1, 10, 20 and 40 µg/mL was found, while in some cases a decrease in insulin secretion was also observed. Artemisia roxburghiana, Salvia coccinia and Monstera deliciosa showed insulin secretagogue activity at 1 µg/mL (p < 0.05) while Abies pindrow, Centaurea iberica and Euphorbia helioscopia were active at 10 µg/mL (p < 0.05). Extracts of Bauhinia variegata and Bergenia himalacia showed effects at 20 µg/mL (p < 0.05), and Taraxacum officinale and Viburnum foetens at 40 µg/mL (p < 0.05). Insulin secretagogue activity could not be detected in the extracts of Adhatoda vasica, Cassia fistula, Chrysanthemum leucanthemum, Morus alba, Plectranthus rugosus, Peganum harmala and Olea ferruginea. The results suggest that medicinal plants of Islamabad and the Murree region of Pakistan may be potential natural resources for antidiabetic compounds. Copyright © 2004 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.1372</identifier><identifier>PMID: 14750205</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Animals ; Biological and medical sciences ; Cell Line - drug effects ; Cell Line - metabolism ; diabetes mellites ; Diabetes Mellitus - prevention & control ; Dose-Response Relationship, Drug ; Flowers ; Fruit ; General pharmacology ; Glyburide - administration & dosage ; Glyburide - pharmacology ; Glyburide - therapeutic use ; Humans ; Hypoglycemic Agents - administration & dosage ; Hypoglycemic Agents - pharmacology ; Hypoglycemic Agents - therapeutic use ; INS-1 cells ; Insulin - metabolism ; Insulin Secretion ; Insulinoma - pathology ; insulinotropic activity ; Medical sciences ; medicinal plants ; Medicine, Traditional ; Pakistan ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phytotherapy ; Plant Components, Aerial ; Plant Extracts - administration & dosage ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Plant Leaves ; Plant Roots ; Plants, Medicinal ; Rats ; Swine</subject><ispartof>Phytotherapy research, 2004-01, Vol.18 (1), p.73-77</ispartof><rights>Copyright © 2004 John Wiley & Sons, Ltd.</rights><rights>2004 INIST-CNRS</rights><rights>Copyright 2004 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3852-386a8a6221339f8be592bfd6b8fc29f8f2983c6409e2b231b9c48d63154dd39c3</citedby><cites>FETCH-LOGICAL-c3852-386a8a6221339f8be592bfd6b8fc29f8f2983c6409e2b231b9c48d63154dd39c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.1372$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.1372$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4010,27900,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15838691$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14750205$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hussain, Zakir</creatorcontrib><creatorcontrib>Waheed, Abdul</creatorcontrib><creatorcontrib>Qureshi, Rizwana Aleem</creatorcontrib><creatorcontrib>Burdi, Dadu Khan</creatorcontrib><creatorcontrib>Verspohl, Eugen J.</creatorcontrib><creatorcontrib>Khan, Naeema</creatorcontrib><creatorcontrib>Hasan, Mashooda</creatorcontrib><title>The effect of medicinal plants of Islamabad and Murree region of Pakistan on insulin secretion from INS-1 cells</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>In vitro testing of the extracts of medicinal plants collected from Islamabad and the Murree region on insulin secretagogue activity was carried out. Dried ethanol extracts of all plants (ZH1‐ZH19) were dissolved in ethanol and DMSO, and tested at various concentrations (between 1 and 40 µg/mL) for insulin release from INS‐1 cells in the presence of 5.5 mM glucose. Glibenclamide was used as a control. Promising insulin secretagogue activity in various plant extracts at 1, 10, 20 and 40 µg/mL was found, while in some cases a decrease in insulin secretion was also observed. Artemisia roxburghiana, Salvia coccinia and Monstera deliciosa showed insulin secretagogue activity at 1 µg/mL (p < 0.05) while Abies pindrow, Centaurea iberica and Euphorbia helioscopia were active at 10 µg/mL (p < 0.05). Extracts of Bauhinia variegata and Bergenia himalacia showed effects at 20 µg/mL (p < 0.05), and Taraxacum officinale and Viburnum foetens at 40 µg/mL (p < 0.05). Insulin secretagogue activity could not be detected in the extracts of Adhatoda vasica, Cassia fistula, Chrysanthemum leucanthemum, Morus alba, Plectranthus rugosus, Peganum harmala and Olea ferruginea. The results suggest that medicinal plants of Islamabad and the Murree region of Pakistan may be potential natural resources for antidiabetic compounds. Copyright © 2004 John Wiley & Sons, Ltd.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Line - drug effects</subject><subject>Cell Line - metabolism</subject><subject>diabetes mellites</subject><subject>Diabetes Mellitus - prevention & control</subject><subject>Dose-Response Relationship, Drug</subject><subject>Flowers</subject><subject>Fruit</subject><subject>General pharmacology</subject><subject>Glyburide - administration & dosage</subject><subject>Glyburide - pharmacology</subject><subject>Glyburide - therapeutic use</subject><subject>Humans</subject><subject>Hypoglycemic Agents - administration & dosage</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>INS-1 cells</subject><subject>Insulin - metabolism</subject><subject>Insulin Secretion</subject><subject>Insulinoma - pathology</subject><subject>insulinotropic activity</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>Medicine, Traditional</subject><subject>Pakistan</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phytotherapy</subject><subject>Plant Components, Aerial</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Leaves</subject><subject>Plant Roots</subject><subject>Plants, Medicinal</subject><subject>Rats</subject><subject>Swine</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1v1DAQhi1ERbcFiV-AfKHqJcUfcWIfUcWWlbalgkUgLpbjjMHUcRY7Ee2_J9FG7YnTjMaP5h0_CL2m5IISwt7th3RBec2eoRUlShVU1Pw5WhElaFFS-f0YneT8mxCiGClfoGNa1oIwIlao3_0CDM6BHXDvcAettz6agPfBxCHPs00OpjONabGJLb4eUwLACX76Ps7Pt-bO58FMfcQ-5jH4iDPYBMMMuNR3eHPzpaDYQgj5JTpyJmR4tdRT9HX9YXf5sdh-utpcvt8WlkvBCi4rI03FGOVcOdmAUKxxbdVIZ9k0cExJbquSKGAN47RRtpRtxako25Yry0_R2WHvPvV_RsiD7nyeLzAR-jFrSSir6opO4PkBtKnPOYHT--Q7kx40JXqWqye5epY7oW-WnWMziXoCF5sT8HYBTLYmuGSi9fmJE3L6l5oziwP31wd4-G-gvt19XoIXfhIN94-8SXe6qnkt9LebK70lkpXr6x96zf8BGceejw</recordid><startdate>200401</startdate><enddate>200401</enddate><creator>Hussain, Zakir</creator><creator>Waheed, Abdul</creator><creator>Qureshi, Rizwana Aleem</creator><creator>Burdi, Dadu Khan</creator><creator>Verspohl, Eugen J.</creator><creator>Khan, Naeema</creator><creator>Hasan, Mashooda</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200401</creationdate><title>The effect of medicinal plants of Islamabad and Murree region of Pakistan on insulin secretion from INS-1 cells</title><author>Hussain, Zakir ; Waheed, Abdul ; Qureshi, Rizwana Aleem ; Burdi, Dadu Khan ; Verspohl, Eugen J. ; Khan, Naeema ; Hasan, Mashooda</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3852-386a8a6221339f8be592bfd6b8fc29f8f2983c6409e2b231b9c48d63154dd39c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Line - drug effects</topic><topic>Cell Line - metabolism</topic><topic>diabetes mellites</topic><topic>Diabetes Mellitus - prevention & control</topic><topic>Dose-Response Relationship, Drug</topic><topic>Flowers</topic><topic>Fruit</topic><topic>General pharmacology</topic><topic>Glyburide - administration & dosage</topic><topic>Glyburide - pharmacology</topic><topic>Glyburide - therapeutic use</topic><topic>Humans</topic><topic>Hypoglycemic Agents - administration & dosage</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>INS-1 cells</topic><topic>Insulin - metabolism</topic><topic>Insulin Secretion</topic><topic>Insulinoma - pathology</topic><topic>insulinotropic activity</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>Medicine, Traditional</topic><topic>Pakistan</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. 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Res</addtitle><date>2004-01</date><risdate>2004</risdate><volume>18</volume><issue>1</issue><spage>73</spage><epage>77</epage><pages>73-77</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>In vitro testing of the extracts of medicinal plants collected from Islamabad and the Murree region on insulin secretagogue activity was carried out. Dried ethanol extracts of all plants (ZH1‐ZH19) were dissolved in ethanol and DMSO, and tested at various concentrations (between 1 and 40 µg/mL) for insulin release from INS‐1 cells in the presence of 5.5 mM glucose. Glibenclamide was used as a control. Promising insulin secretagogue activity in various plant extracts at 1, 10, 20 and 40 µg/mL was found, while in some cases a decrease in insulin secretion was also observed. Artemisia roxburghiana, Salvia coccinia and Monstera deliciosa showed insulin secretagogue activity at 1 µg/mL (p < 0.05) while Abies pindrow, Centaurea iberica and Euphorbia helioscopia were active at 10 µg/mL (p < 0.05). Extracts of Bauhinia variegata and Bergenia himalacia showed effects at 20 µg/mL (p < 0.05), and Taraxacum officinale and Viburnum foetens at 40 µg/mL (p < 0.05). Insulin secretagogue activity could not be detected in the extracts of Adhatoda vasica, Cassia fistula, Chrysanthemum leucanthemum, Morus alba, Plectranthus rugosus, Peganum harmala and Olea ferruginea. The results suggest that medicinal plants of Islamabad and the Murree region of Pakistan may be potential natural resources for antidiabetic compounds. Copyright © 2004 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>14750205</pmid><doi>10.1002/ptr.1372</doi><tpages>5</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Cell Line - drug effects Cell Line - metabolism diabetes mellites Diabetes Mellitus - prevention & control Dose-Response Relationship, Drug Flowers Fruit General pharmacology Glyburide - administration & dosage Glyburide - pharmacology Glyburide - therapeutic use Humans Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use INS-1 cells Insulin - metabolism Insulin Secretion Insulinoma - pathology insulinotropic activity Medical sciences medicinal plants Medicine, Traditional Pakistan Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Components, Aerial Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Leaves Plant Roots Plants, Medicinal Rats Swine |
| title | The effect of medicinal plants of Islamabad and Murree region of Pakistan on insulin secretion from INS-1 cells |
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