Nephrotic syndrome in Saudi children clinicopathological study of 150 cases
The study includes 150 children with primary nephrotic syndrome (NS), aged 16 months to 13 years with a median age of 5 years. The male to female ratio was 2:1 and the familial occurrence was 6%. Amongst 48 biopsied patients, 19 (39%) had focal segmental glomerulosclerosis, 17 (35%) had diffuse mesa...
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| Veröffentlicht in: | Pediatric nephrology (Berlin, West) West), 1990-09, Vol.4 (5), p.517-519 |
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| container_title | Pediatric nephrology (Berlin, West) |
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| creator | MATTOO, T. K MAHMOOD, M. A AL-HARBI, M. S |
| description | The study includes 150 children with primary nephrotic syndrome (NS), aged 16 months to 13 years with a median age of 5 years. The male to female ratio was 2:1 and the familial occurrence was 6%. Amongst 48 biopsied patients, 19 (39%) had focal segmental glomerulosclerosis, 17 (35%) had diffuse mesangial proliferative glomerulonephritis (MesPGN) and 10 (21%) had minimal change nephropathy. About 90% of patients responded to the initial prednisolone therapy. Subsequently 45% of steroid-sensitive patients had frequent relapses, 23% had no relapses, 21% had infrequent relapses and 5% became steroid resistant. Saudi children with primary NS showed no differences as regards age at onset, male predominance and response to initial prednisolone therapy when compared with published data from other countries. However, the higher incidence of familial occurrence, the relatively high frequency of MesPGN, the rarity of infection-related NS and a decreasing incidence of serious infections with improving socio-economic status were all noteworthy. |
| doi_str_mv | 10.1007/BF00869837 |
| format | Article |
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However, the higher incidence of familial occurrence, the relatively high frequency of MesPGN, the rarity of infection-related NS and a decreasing incidence of serious infections with improving socio-economic status were all noteworthy.</description><identifier>ISSN: 0931-041X</identifier><identifier>EISSN: 1432-198X</identifier><identifier>DOI: 10.1007/BF00869837</identifier><identifier>PMID: 2242321</identifier><identifier>CODEN: PENED3</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adolescent ; Biological and medical sciences ; Biopsy ; Child ; Child, Preschool ; Female ; Glomerulonephritis ; Humans ; Infant ; Male ; Medical sciences ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Nephrotic Syndrome - drug therapy ; Nephrotic Syndrome - epidemiology ; Nephrotic Syndrome - pathology ; Pedigree ; Prednisolone - therapeutic use ; Recurrence ; Saudi Arabia - epidemiology ; Socioeconomic Factors ; Tropical medicine</subject><ispartof>Pediatric nephrology (Berlin, West), 1990-09, Vol.4 (5), p.517-519</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c312t-ac2d71a3f4d0e0ea960cd0b4ee471e4091374dfcbe17195b7e2036f76cd34aef3</citedby><cites>FETCH-LOGICAL-c312t-ac2d71a3f4d0e0ea960cd0b4ee471e4091374dfcbe17195b7e2036f76cd34aef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19671175$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2242321$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MATTOO, T. K</creatorcontrib><creatorcontrib>MAHMOOD, M. A</creatorcontrib><creatorcontrib>AL-HARBI, M. S</creatorcontrib><title>Nephrotic syndrome in Saudi children clinicopathological study of 150 cases</title><title>Pediatric nephrology (Berlin, West)</title><addtitle>Pediatr Nephrol</addtitle><description>The study includes 150 children with primary nephrotic syndrome (NS), aged 16 months to 13 years with a median age of 5 years. The male to female ratio was 2:1 and the familial occurrence was 6%. Amongst 48 biopsied patients, 19 (39%) had focal segmental glomerulosclerosis, 17 (35%) had diffuse mesangial proliferative glomerulonephritis (MesPGN) and 10 (21%) had minimal change nephropathy. About 90% of patients responded to the initial prednisolone therapy. Subsequently 45% of steroid-sensitive patients had frequent relapses, 23% had no relapses, 21% had infrequent relapses and 5% became steroid resistant. Saudi children with primary NS showed no differences as regards age at onset, male predominance and response to initial prednisolone therapy when compared with published data from other countries. However, the higher incidence of familial occurrence, the relatively high frequency of MesPGN, the rarity of infection-related NS and a decreasing incidence of serious infections with improving socio-economic status were all noteworthy.</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Glomerulonephritis</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Nephrotic Syndrome - drug therapy</subject><subject>Nephrotic Syndrome - epidemiology</subject><subject>Nephrotic Syndrome - pathology</subject><subject>Pedigree</subject><subject>Prednisolone - therapeutic use</subject><subject>Recurrence</subject><subject>Saudi Arabia - epidemiology</subject><subject>Socioeconomic Factors</subject><subject>Tropical medicine</subject><issn>0931-041X</issn><issn>1432-198X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkDFPwzAQRi0EglJY2JG8wIAUuLPdOBmhooBAMABSt8i1L9QojYudDP33BFHBdMP39KR7jJ0gXCKAvrqZARR5WUi9w0aopMiwLOa7bASlxAwUzg_YYUqfMGCTIt9n-0IoIQWO2OMzrZcxdN7ytGldDCvivuWvpnee26VvXKSW28a33oa16ZahCR_emoanrncbHmqOE-DWJEpHbK82TaLj7R2z99nt2_Q-e3q5e5heP2VWougyY4XTaGStHBCQKXOwDhaKSGkkBSVKrVxtF4Qay8lCkwCZ1zq3TipDtRyz81_vOoavnlJXrXyy1DSmpdCnqgAUeS5hAC9-QRtDSpHqah39ysRNhVD9lKv-yw3w6dbaL1bk_tBtqmE_2-4mDf_X0bTWp39jmWtEPZHfCot1VQ</recordid><startdate>19900901</startdate><enddate>19900901</enddate><creator>MATTOO, T. K</creator><creator>MAHMOOD, M. A</creator><creator>AL-HARBI, M. S</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900901</creationdate><title>Nephrotic syndrome in Saudi children clinicopathological study of 150 cases</title><author>MATTOO, T. K ; MAHMOOD, M. A ; AL-HARBI, M. S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c312t-ac2d71a3f4d0e0ea960cd0b4ee471e4091374dfcbe17195b7e2036f76cd34aef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Glomerulonephritis</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Nephrotic Syndrome - drug therapy</topic><topic>Nephrotic Syndrome - epidemiology</topic><topic>Nephrotic Syndrome - pathology</topic><topic>Pedigree</topic><topic>Prednisolone - therapeutic use</topic><topic>Recurrence</topic><topic>Saudi Arabia - epidemiology</topic><topic>Socioeconomic Factors</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MATTOO, T. K</creatorcontrib><creatorcontrib>MAHMOOD, M. A</creatorcontrib><creatorcontrib>AL-HARBI, M. S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric nephrology (Berlin, West)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MATTOO, T. K</au><au>MAHMOOD, M. A</au><au>AL-HARBI, M. S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nephrotic syndrome in Saudi children clinicopathological study of 150 cases</atitle><jtitle>Pediatric nephrology (Berlin, West)</jtitle><addtitle>Pediatr Nephrol</addtitle><date>1990-09-01</date><risdate>1990</risdate><volume>4</volume><issue>5</issue><spage>517</spage><epage>519</epage><pages>517-519</pages><issn>0931-041X</issn><eissn>1432-198X</eissn><coden>PENED3</coden><abstract>The study includes 150 children with primary nephrotic syndrome (NS), aged 16 months to 13 years with a median age of 5 years. The male to female ratio was 2:1 and the familial occurrence was 6%. Amongst 48 biopsied patients, 19 (39%) had focal segmental glomerulosclerosis, 17 (35%) had diffuse mesangial proliferative glomerulonephritis (MesPGN) and 10 (21%) had minimal change nephropathy. About 90% of patients responded to the initial prednisolone therapy. Subsequently 45% of steroid-sensitive patients had frequent relapses, 23% had no relapses, 21% had infrequent relapses and 5% became steroid resistant. Saudi children with primary NS showed no differences as regards age at onset, male predominance and response to initial prednisolone therapy when compared with published data from other countries. However, the higher incidence of familial occurrence, the relatively high frequency of MesPGN, the rarity of infection-related NS and a decreasing incidence of serious infections with improving socio-economic status were all noteworthy.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>2242321</pmid><doi>10.1007/BF00869837</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0931-041X |
| ispartof | Pediatric nephrology (Berlin, West), 1990-09, Vol.4 (5), p.517-519 |
| issn | 0931-041X 1432-198X |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adolescent Biological and medical sciences Biopsy Child Child, Preschool Female Glomerulonephritis Humans Infant Male Medical sciences Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Nephrotic Syndrome - drug therapy Nephrotic Syndrome - epidemiology Nephrotic Syndrome - pathology Pedigree Prednisolone - therapeutic use Recurrence Saudi Arabia - epidemiology Socioeconomic Factors Tropical medicine |
| title | Nephrotic syndrome in Saudi children clinicopathological study of 150 cases |
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