Levels of oxidative stress and redox-related molecules in the placenta in preeclampsia and fetal growth restriction
Recent evidence suggests that oxidative stress is involved in the pathophysiology of preeclampsia. Using immunohistochemistry and Western blotting, we investigated the oxidative stress- and redox-related molecules, such as 8-hydroxy-2'-deoxyguanosine (8-OHdG), 4-hydroxynonenal (4-HNE), thioredo...
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| Veröffentlicht in: | Virchows Archiv : an international journal of pathology 2004, Vol.444 (1), p.49-55 |
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| creator | TAKAGI, Yasushi NIKAIDO, Toshio TOKI, Toshihiko KITA, Naoko KANAI, Makoto ASHIDA, Takashi OHIRA, Satoshi KONISHI, Ikuo |
| description | Recent evidence suggests that oxidative stress is involved in the pathophysiology of preeclampsia. Using immunohistochemistry and Western blotting, we investigated the oxidative stress- and redox-related molecules, such as 8-hydroxy-2'-deoxyguanosine (8-OHdG), 4-hydroxynonenal (4-HNE), thioredoxin (TRX) and redox factor-1 (ref-1) in the placenta in preeclampsia, intrauterine growth restriction (IUGR), preeclampsia + IUGR and in normal pregnancy. Using immunohistochemistry, the level of 8-OHdG was significantly higher in IUGR ( P=0.012) or preeclampsia + IUGR (P=0.0021) than in normal pregnancy, while TRX expression was significantly higher in preeclampsia (P=0.045), and ref-1 expression was significantly higher in preeclampsia (P=0.017), IUGR (P=0.016) and preeclampsia + IUGR (P=0.0038) than in normal pregnancy. The levels of 4-HNE did not differ significantly between either preeclampsia or IUGR and normal pregnancy. A significant positive correlation was observed between TRX and ref-1 expressions in both normal (rho=0.52) and complicated (rho=0.43) pregnancies. Using Western blotting, ref-1 expression tended to be higher in complicated pregnancies than in normal pregnancy (P=0.09). These results suggest that oxidative DNA damage is increased in IUGR and that redox function is enhanced in both preeclampsia and IUGR compared with normal pregnancy. |
| doi_str_mv | 10.1007/s00428-003-0903-2 |
| format | Article |
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Using immunohistochemistry and Western blotting, we investigated the oxidative stress- and redox-related molecules, such as 8-hydroxy-2'-deoxyguanosine (8-OHdG), 4-hydroxynonenal (4-HNE), thioredoxin (TRX) and redox factor-1 (ref-1) in the placenta in preeclampsia, intrauterine growth restriction (IUGR), preeclampsia + IUGR and in normal pregnancy. Using immunohistochemistry, the level of 8-OHdG was significantly higher in IUGR ( P=0.012) or preeclampsia + IUGR (P=0.0021) than in normal pregnancy, while TRX expression was significantly higher in preeclampsia (P=0.045), and ref-1 expression was significantly higher in preeclampsia (P=0.017), IUGR (P=0.016) and preeclampsia + IUGR (P=0.0038) than in normal pregnancy. The levels of 4-HNE did not differ significantly between either preeclampsia or IUGR and normal pregnancy. A significant positive correlation was observed between TRX and ref-1 expressions in both normal (rho=0.52) and complicated (rho=0.43) pregnancies. Using Western blotting, ref-1 expression tended to be higher in complicated pregnancies than in normal pregnancy (P=0.09). These results suggest that oxidative DNA damage is increased in IUGR and that redox function is enhanced in both preeclampsia and IUGR compared with normal pregnancy.</description><identifier>ISSN: 0945-6317</identifier><identifier>EISSN: 1432-2307</identifier><identifier>DOI: 10.1007/s00428-003-0903-2</identifier><identifier>PMID: 14574573</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Aldehydes - analysis ; Antioxidants ; Biological and medical sciences ; Blotting, Western ; Deoxyguanosine - analogs & derivatives ; Deoxyguanosine - analysis ; Diseases of mother, fetus and pregnancy ; DNA Damage ; DNA-(Apurinic or Apyrimidinic Site) Lyase - analysis ; Female ; Fetal Growth Retardation - etiology ; Fetal Growth Retardation - metabolism ; Gestational Age ; Gynecology. Andrology. Obstetrics ; Humans ; Immunohistochemistry ; Investigative techniques, diagnostic techniques (general aspects) ; Medical sciences ; Oxidation-Reduction ; Oxidative Stress ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Placenta - chemistry ; Pre-Eclampsia - etiology ; Pre-Eclampsia - metabolism ; Preeclampsia ; Pregnancy ; Pregnancy. Fetus. 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Using immunohistochemistry and Western blotting, we investigated the oxidative stress- and redox-related molecules, such as 8-hydroxy-2'-deoxyguanosine (8-OHdG), 4-hydroxynonenal (4-HNE), thioredoxin (TRX) and redox factor-1 (ref-1) in the placenta in preeclampsia, intrauterine growth restriction (IUGR), preeclampsia + IUGR and in normal pregnancy. Using immunohistochemistry, the level of 8-OHdG was significantly higher in IUGR ( P=0.012) or preeclampsia + IUGR (P=0.0021) than in normal pregnancy, while TRX expression was significantly higher in preeclampsia (P=0.045), and ref-1 expression was significantly higher in preeclampsia (P=0.017), IUGR (P=0.016) and preeclampsia + IUGR (P=0.0038) than in normal pregnancy. The levels of 4-HNE did not differ significantly between either preeclampsia or IUGR and normal pregnancy. A significant positive correlation was observed between TRX and ref-1 expressions in both normal (rho=0.52) and complicated (rho=0.43) pregnancies. Using Western blotting, ref-1 expression tended to be higher in complicated pregnancies than in normal pregnancy (P=0.09). These results suggest that oxidative DNA damage is increased in IUGR and that redox function is enhanced in both preeclampsia and IUGR compared with normal pregnancy.</description><subject>Aldehydes - analysis</subject><subject>Antioxidants</subject><subject>Biological and medical sciences</subject><subject>Blotting, Western</subject><subject>Deoxyguanosine - analogs & derivatives</subject><subject>Deoxyguanosine - analysis</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>DNA Damage</subject><subject>DNA-(Apurinic or Apyrimidinic Site) Lyase - analysis</subject><subject>Female</subject><subject>Fetal Growth Retardation - etiology</subject><subject>Fetal Growth Retardation - metabolism</subject><subject>Gestational Age</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Medical sciences</subject><subject>Oxidation-Reduction</subject><subject>Oxidative Stress</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Placenta - chemistry</subject><subject>Pre-Eclampsia - etiology</subject><subject>Pre-Eclampsia - metabolism</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. 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Andrology. Obstetrics</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Medical sciences</topic><topic>Oxidation-Reduction</topic><topic>Oxidative Stress</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Placenta - chemistry</topic><topic>Pre-Eclampsia - etiology</topic><topic>Pre-Eclampsia - metabolism</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. 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Using immunohistochemistry and Western blotting, we investigated the oxidative stress- and redox-related molecules, such as 8-hydroxy-2'-deoxyguanosine (8-OHdG), 4-hydroxynonenal (4-HNE), thioredoxin (TRX) and redox factor-1 (ref-1) in the placenta in preeclampsia, intrauterine growth restriction (IUGR), preeclampsia + IUGR and in normal pregnancy. Using immunohistochemistry, the level of 8-OHdG was significantly higher in IUGR ( P=0.012) or preeclampsia + IUGR (P=0.0021) than in normal pregnancy, while TRX expression was significantly higher in preeclampsia (P=0.045), and ref-1 expression was significantly higher in preeclampsia (P=0.017), IUGR (P=0.016) and preeclampsia + IUGR (P=0.0038) than in normal pregnancy. The levels of 4-HNE did not differ significantly between either preeclampsia or IUGR and normal pregnancy. A significant positive correlation was observed between TRX and ref-1 expressions in both normal (rho=0.52) and complicated (rho=0.43) pregnancies. Using Western blotting, ref-1 expression tended to be higher in complicated pregnancies than in normal pregnancy (P=0.09). These results suggest that oxidative DNA damage is increased in IUGR and that redox function is enhanced in both preeclampsia and IUGR compared with normal pregnancy.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>14574573</pmid><doi>10.1007/s00428-003-0903-2</doi><tpages>7</tpages></addata></record> |
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| subjects | Aldehydes - analysis Antioxidants Biological and medical sciences Blotting, Western Deoxyguanosine - analogs & derivatives Deoxyguanosine - analysis Diseases of mother, fetus and pregnancy DNA Damage DNA-(Apurinic or Apyrimidinic Site) Lyase - analysis Female Fetal Growth Retardation - etiology Fetal Growth Retardation - metabolism Gestational Age Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Medical sciences Oxidation-Reduction Oxidative Stress Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Placenta - chemistry Pre-Eclampsia - etiology Pre-Eclampsia - metabolism Preeclampsia Pregnancy Pregnancy. Fetus. Placenta Thioredoxins - analysis |
| title | Levels of oxidative stress and redox-related molecules in the placenta in preeclampsia and fetal growth restriction |
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