Overexpression of glutathione peroxidase prevents left ventricular remodeling and failure after myocardial infarction in mice

Oxidative stress plays an important role in the pathophysiology of heart failure. We determined whether the overexpression of glutathione peroxidase (GSHPx) could attenuate left ventricular (LV) remodeling and failure after myocardial infarction (MI). We created MI in 12- to 16-week-old, male GSHPx...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2004-02, Vol.109 (4), p.544-549
Hauptverfasser:	SHIOMI, Tetsuya, TSUTSUI, Hiroyuki, MATSUSAKA, Hidenori, MURAKAMI, Kimiyo, HAYASHIDANI, Shunji, IKEUCHI, Masaki, JING WEN, KUBOTA, Toru, UTSUMI, Hideo, TAKESHITA, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - metabolism Apoptosis Biological and medical sciences Blood and lymphatic vessels Cardiac Output, Low - physiopathology Cardiac Output, Low - prevention & control Cardiology. Vascular system Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Gene Expression Glutathione Peroxidase - genetics Glutathione Peroxidase - metabolism Hemodynamics Male Matrix Metalloproteinases - metabolism Medical sciences Mice Mice, Transgenic Myocardial Infarction - metabolism Myocardial Infarction - pathology Myocardial Infarction - therapy Myocardium - enzymology Myocardium - metabolism Myocardium - pathology Organ Size Survival Analysis Thiobarbituric Acid Reactive Substances - analysis Ventricular Dysfunction, Left - pathology Ventricular Dysfunction, Left - physiopathology Ventricular Dysfunction, Left - prevention & control Ventricular Remodeling
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