Common alterations in gene expression and increased proliferation in recurrent acute myeloid leukemia

Recurrent disease following high-dose chemotherapy is a major problem in patients with acute myeloid leukemia (AML). To identify its characteristics, we performed expression profiling in blasts from untreated AML and relapse, using a specific cDNA microarray comprising 4128 genes generated by cDNA s...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Oncogene 2004-01, Vol.23 (4), p.894-904
Hauptverfasser: Staber, Philipp Bernhard, Linkesch, Werner, Zauner, Dorothea, Beham-Schmid, Christine, Guelly, Christian, Schauer, Silvia, Sill, Heinz, Hoefler, Gerald
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 904
container_issue 4
container_start_page 894
container_title Oncogene
container_volume 23
creator Staber, Philipp Bernhard
Linkesch, Werner
Zauner, Dorothea
Beham-Schmid, Christine
Guelly, Christian
Schauer, Silvia
Sill, Heinz
Hoefler, Gerald
description Recurrent disease following high-dose chemotherapy is a major problem in patients with acute myeloid leukemia (AML). To identify its characteristics, we performed expression profiling in blasts from untreated AML and relapse, using a specific cDNA microarray comprising 4128 genes generated by cDNA subtraction supplemented with cancer-associated genes. Expression analysis of 18 AML bone marrow specimens showed that recurrent AML is commonly associated with the mRNA expression changes in a set of 58 genes. Increased cellular proliferation was indicated by the overexpression of the transferrin receptor, proliferating cell nuclear antigen, and G1 cyclins. An immunohistochemical study for Ki-67-positive blasts in 18 paired bone marrow biopsy samples confirmed a highly significant ( P
doi_str_mv 10.1038/sj.onc.1207192
format Article
fullrecord <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_80125254</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A189099945</galeid><sourcerecordid>A189099945</sourcerecordid><originalsourceid>FETCH-LOGICAL-c586t-7b739bc0774650cd7a329a6b5b4ef28a733e3b64dde69dba56f17e560987b6263</originalsourceid><addsrcrecordid>eNqFkc2LFDEQxYMo7uzq1ZvSCOutZ_OdznEZ_IIFL3oO6XT1kDGdjEk37P73ZpiGEUEkh0DV771U5SH0huAtway7K4dtim5LKFZE02doQ7iSrRCaP0cbrAVuNWX0Cl2XcsAYK43pS3RVIa6VpBsEuzRNKTY2zJDt7FMsjY_NHiI08HjMUIo_teNQyy6DLTA0x5yCH1f-hGdwS84Q58a6ZYZmeoKQ_NAEWH7C5O0r9GK0ocDr9b5BPz59_L770j58-_x1d__QOtHJuVW9Yrp3WCkuBXaDsoxqK3vRcxhpZxVjwHrJhwGkHnor5EgUCIl1p3pJJbtBH86-dcJfC5TZTL44CMFGSEsxHSZUUMH_C9a_lB2WJ8f3f4GHtORYlzCUKiYo1aJC2zO0twGMj2Oas3X1DHV5lyKMvtbvSaex1pr_IXA5lZJhNMfsJ5ufDMHmlKspB1NzNWuuVfBuHWPpJxgu-BpkBW5XwBZnw5htdL5cOCEVZ0RX7u7MldqKe8iXff759NuzItp5yXCxXPu_Abm7xcw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>227352295</pqid></control><display><type>article</type><title>Common alterations in gene expression and increased proliferation in recurrent acute myeloid leukemia</title><source>MEDLINE</source><source>Nature Journals Online</source><source>EZB-FREE-00999 freely available EZB journals</source><source>SpringerLink Journals - AutoHoldings</source><creator>Staber, Philipp Bernhard ; Linkesch, Werner ; Zauner, Dorothea ; Beham-Schmid, Christine ; Guelly, Christian ; Schauer, Silvia ; Sill, Heinz ; Hoefler, Gerald</creator><creatorcontrib>Staber, Philipp Bernhard ; Linkesch, Werner ; Zauner, Dorothea ; Beham-Schmid, Christine ; Guelly, Christian ; Schauer, Silvia ; Sill, Heinz ; Hoefler, Gerald</creatorcontrib><description>Recurrent disease following high-dose chemotherapy is a major problem in patients with acute myeloid leukemia (AML). To identify its characteristics, we performed expression profiling in blasts from untreated AML and relapse, using a specific cDNA microarray comprising 4128 genes generated by cDNA subtraction supplemented with cancer-associated genes. Expression analysis of 18 AML bone marrow specimens showed that recurrent AML is commonly associated with the mRNA expression changes in a set of 58 genes. Increased cellular proliferation was indicated by the overexpression of the transferrin receptor, proliferating cell nuclear antigen, and G1 cyclins. An immunohistochemical study for Ki-67-positive blasts in 18 paired bone marrow biopsy samples confirmed a highly significant ( P &lt;0.0001) increase in the proliferation fraction at relapse. In addition, we found enhanced activation of the RAF/MEK/ERK cascade as mRNAs of MKP-1, c- jun , c- fos , and egr-1 were significantly increased at relapse. Immunohistochemistry and immunoblotting analyses for biphosphorylated ERK1/2 protein provide additional evidence for enhanced activation of the RAF/MEK/ERK pathway. The degree of increase is significantly correlated with the increased proliferation. Furthermore, the genes identified provide a rationale for further studies on predictive diagnosis and therapeutic intervention.</description><identifier>ISSN: 0950-9232</identifier><identifier>EISSN: 1476-5594</identifier><identifier>DOI: 10.1038/sj.onc.1207192</identifier><identifier>PMID: 14749762</identifier><identifier>CODEN: ONCNES</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Acute Disease ; Adult ; Aged ; Apoptosis ; Biological and medical sciences ; Blotting, Western ; Bone marrow ; Cell Biology ; Cell Division ; Cell physiology ; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes ; Chemotherapy ; Cloning ; DNA, Complementary ; Fundamental and applied biological sciences. Psychology ; Gene Expression ; Hematologic and hematopoietic diseases ; Human Genetics ; Humans ; Immunohistochemistry ; Internal Medicine ; Kinases ; Leukemia ; Leukemia, Myeloid - enzymology ; Leukemia, Myeloid - genetics ; Leukemia, Myeloid - pathology ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Medical sciences ; Medicine ; Medicine &amp; Public Health ; Middle Aged ; Mitogen-Activated Protein Kinases - metabolism ; Molecular and cellular biology ; Oligonucleotide Array Sequence Analysis ; Oncology ; original-paper ; Proteins ; Recurrence ; Reverse Transcriptase Polymerase Chain Reaction</subject><ispartof>Oncogene, 2004-01, Vol.23 (4), p.894-904</ispartof><rights>Springer Nature Limited 2004</rights><rights>2004 INIST-CNRS</rights><rights>COPYRIGHT 2004 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jan 29, 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c586t-7b739bc0774650cd7a329a6b5b4ef28a733e3b64dde69dba56f17e560987b6263</citedby><cites>FETCH-LOGICAL-c586t-7b739bc0774650cd7a329a6b5b4ef28a733e3b64dde69dba56f17e560987b6263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.onc.1207192$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.onc.1207192$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,2725,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=15674319$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14749762$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Staber, Philipp Bernhard</creatorcontrib><creatorcontrib>Linkesch, Werner</creatorcontrib><creatorcontrib>Zauner, Dorothea</creatorcontrib><creatorcontrib>Beham-Schmid, Christine</creatorcontrib><creatorcontrib>Guelly, Christian</creatorcontrib><creatorcontrib>Schauer, Silvia</creatorcontrib><creatorcontrib>Sill, Heinz</creatorcontrib><creatorcontrib>Hoefler, Gerald</creatorcontrib><title>Common alterations in gene expression and increased proliferation in recurrent acute myeloid leukemia</title><title>Oncogene</title><addtitle>Oncogene</addtitle><addtitle>Oncogene</addtitle><description>Recurrent disease following high-dose chemotherapy is a major problem in patients with acute myeloid leukemia (AML). To identify its characteristics, we performed expression profiling in blasts from untreated AML and relapse, using a specific cDNA microarray comprising 4128 genes generated by cDNA subtraction supplemented with cancer-associated genes. Expression analysis of 18 AML bone marrow specimens showed that recurrent AML is commonly associated with the mRNA expression changes in a set of 58 genes. Increased cellular proliferation was indicated by the overexpression of the transferrin receptor, proliferating cell nuclear antigen, and G1 cyclins. An immunohistochemical study for Ki-67-positive blasts in 18 paired bone marrow biopsy samples confirmed a highly significant ( P &lt;0.0001) increase in the proliferation fraction at relapse. In addition, we found enhanced activation of the RAF/MEK/ERK cascade as mRNAs of MKP-1, c- jun , c- fos , and egr-1 were significantly increased at relapse. Immunohistochemistry and immunoblotting analyses for biphosphorylated ERK1/2 protein provide additional evidence for enhanced activation of the RAF/MEK/ERK pathway. The degree of increase is significantly correlated with the increased proliferation. Furthermore, the genes identified provide a rationale for further studies on predictive diagnosis and therapeutic intervention.</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Aged</subject><subject>Apoptosis</subject><subject>Biological and medical sciences</subject><subject>Blotting, Western</subject><subject>Bone marrow</subject><subject>Cell Biology</subject><subject>Cell Division</subject><subject>Cell physiology</subject><subject>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</subject><subject>Chemotherapy</subject><subject>Cloning</subject><subject>DNA, Complementary</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Internal Medicine</subject><subject>Kinases</subject><subject>Leukemia</subject><subject>Leukemia, Myeloid - enzymology</subject><subject>Leukemia, Myeloid - genetics</subject><subject>Leukemia, Myeloid - pathology</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Middle Aged</subject><subject>Mitogen-Activated Protein Kinases - metabolism</subject><subject>Molecular and cellular biology</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Oncology</subject><subject>original-paper</subject><subject>Proteins</subject><subject>Recurrence</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><issn>0950-9232</issn><issn>1476-5594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkc2LFDEQxYMo7uzq1ZvSCOutZ_OdznEZ_IIFL3oO6XT1kDGdjEk37P73ZpiGEUEkh0DV771U5SH0huAtway7K4dtim5LKFZE02doQ7iSrRCaP0cbrAVuNWX0Cl2XcsAYK43pS3RVIa6VpBsEuzRNKTY2zJDt7FMsjY_NHiI08HjMUIo_teNQyy6DLTA0x5yCH1f-hGdwS84Q58a6ZYZmeoKQ_NAEWH7C5O0r9GK0ocDr9b5BPz59_L770j58-_x1d__QOtHJuVW9Yrp3WCkuBXaDsoxqK3vRcxhpZxVjwHrJhwGkHnor5EgUCIl1p3pJJbtBH86-dcJfC5TZTL44CMFGSEsxHSZUUMH_C9a_lB2WJ8f3f4GHtORYlzCUKiYo1aJC2zO0twGMj2Oas3X1DHV5lyKMvtbvSaex1pr_IXA5lZJhNMfsJ5ufDMHmlKspB1NzNWuuVfBuHWPpJxgu-BpkBW5XwBZnw5htdL5cOCEVZ0RX7u7MldqKe8iXff759NuzItp5yXCxXPu_Abm7xcw</recordid><startdate>20040129</startdate><enddate>20040129</enddate><creator>Staber, Philipp Bernhard</creator><creator>Linkesch, Werner</creator><creator>Zauner, Dorothea</creator><creator>Beham-Schmid, Christine</creator><creator>Guelly, Christian</creator><creator>Schauer, Silvia</creator><creator>Sill, Heinz</creator><creator>Hoefler, Gerald</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20040129</creationdate><title>Common alterations in gene expression and increased proliferation in recurrent acute myeloid leukemia</title><author>Staber, Philipp Bernhard ; Linkesch, Werner ; Zauner, Dorothea ; Beham-Schmid, Christine ; Guelly, Christian ; Schauer, Silvia ; Sill, Heinz ; Hoefler, Gerald</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c586t-7b739bc0774650cd7a329a6b5b4ef28a733e3b64dde69dba56f17e560987b6263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Acute Disease</topic><topic>Adult</topic><topic>Aged</topic><topic>Apoptosis</topic><topic>Biological and medical sciences</topic><topic>Blotting, Western</topic><topic>Bone marrow</topic><topic>Cell Biology</topic><topic>Cell Division</topic><topic>Cell physiology</topic><topic>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</topic><topic>Chemotherapy</topic><topic>Cloning</topic><topic>DNA, Complementary</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Internal Medicine</topic><topic>Kinases</topic><topic>Leukemia</topic><topic>Leukemia, Myeloid - enzymology</topic><topic>Leukemia, Myeloid - genetics</topic><topic>Leukemia, Myeloid - pathology</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Middle Aged</topic><topic>Mitogen-Activated Protein Kinases - metabolism</topic><topic>Molecular and cellular biology</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Oncology</topic><topic>original-paper</topic><topic>Proteins</topic><topic>Recurrence</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Staber, Philipp Bernhard</creatorcontrib><creatorcontrib>Linkesch, Werner</creatorcontrib><creatorcontrib>Zauner, Dorothea</creatorcontrib><creatorcontrib>Beham-Schmid, Christine</creatorcontrib><creatorcontrib>Guelly, Christian</creatorcontrib><creatorcontrib>Schauer, Silvia</creatorcontrib><creatorcontrib>Sill, Heinz</creatorcontrib><creatorcontrib>Hoefler, Gerald</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Oncogene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Staber, Philipp Bernhard</au><au>Linkesch, Werner</au><au>Zauner, Dorothea</au><au>Beham-Schmid, Christine</au><au>Guelly, Christian</au><au>Schauer, Silvia</au><au>Sill, Heinz</au><au>Hoefler, Gerald</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Common alterations in gene expression and increased proliferation in recurrent acute myeloid leukemia</atitle><jtitle>Oncogene</jtitle><stitle>Oncogene</stitle><addtitle>Oncogene</addtitle><date>2004-01-29</date><risdate>2004</risdate><volume>23</volume><issue>4</issue><spage>894</spage><epage>904</epage><pages>894-904</pages><issn>0950-9232</issn><eissn>1476-5594</eissn><coden>ONCNES</coden><abstract>Recurrent disease following high-dose chemotherapy is a major problem in patients with acute myeloid leukemia (AML). To identify its characteristics, we performed expression profiling in blasts from untreated AML and relapse, using a specific cDNA microarray comprising 4128 genes generated by cDNA subtraction supplemented with cancer-associated genes. Expression analysis of 18 AML bone marrow specimens showed that recurrent AML is commonly associated with the mRNA expression changes in a set of 58 genes. Increased cellular proliferation was indicated by the overexpression of the transferrin receptor, proliferating cell nuclear antigen, and G1 cyclins. An immunohistochemical study for Ki-67-positive blasts in 18 paired bone marrow biopsy samples confirmed a highly significant ( P &lt;0.0001) increase in the proliferation fraction at relapse. In addition, we found enhanced activation of the RAF/MEK/ERK cascade as mRNAs of MKP-1, c- jun , c- fos , and egr-1 were significantly increased at relapse. Immunohistochemistry and immunoblotting analyses for biphosphorylated ERK1/2 protein provide additional evidence for enhanced activation of the RAF/MEK/ERK pathway. The degree of increase is significantly correlated with the increased proliferation. Furthermore, the genes identified provide a rationale for further studies on predictive diagnosis and therapeutic intervention.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>14749762</pmid><doi>10.1038/sj.onc.1207192</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0950-9232
ispartof Oncogene, 2004-01, Vol.23 (4), p.894-904
issn 0950-9232
1476-5594
language eng
recordid cdi_proquest_miscellaneous_80125254
source MEDLINE; Nature Journals Online; EZB-FREE-00999 freely available EZB journals; SpringerLink Journals - AutoHoldings
subjects Acute Disease
Adult
Aged
Apoptosis
Biological and medical sciences
Blotting, Western
Bone marrow
Cell Biology
Cell Division
Cell physiology
Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes
Chemotherapy
Cloning
DNA, Complementary
Fundamental and applied biological sciences. Psychology
Gene Expression
Hematologic and hematopoietic diseases
Human Genetics
Humans
Immunohistochemistry
Internal Medicine
Kinases
Leukemia
Leukemia, Myeloid - enzymology
Leukemia, Myeloid - genetics
Leukemia, Myeloid - pathology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Mitogen-Activated Protein Kinases - metabolism
Molecular and cellular biology
Oligonucleotide Array Sequence Analysis
Oncology
original-paper
Proteins
Recurrence
Reverse Transcriptase Polymerase Chain Reaction
title Common alterations in gene expression and increased proliferation in recurrent acute myeloid leukemia
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T13%3A02%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Common%20alterations%20in%20gene%20expression%20and%20increased%20proliferation%20in%20recurrent%20acute%20myeloid%20leukemia&rft.jtitle=Oncogene&rft.au=Staber,%20Philipp%20Bernhard&rft.date=2004-01-29&rft.volume=23&rft.issue=4&rft.spage=894&rft.epage=904&rft.pages=894-904&rft.issn=0950-9232&rft.eissn=1476-5594&rft.coden=ONCNES&rft_id=info:doi/10.1038/sj.onc.1207192&rft_dat=%3Cgale_proqu%3EA189099945%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=227352295&rft_id=info:pmid/14749762&rft_galeid=A189099945&rfr_iscdi=true