Comparative studies of potential cancer biomarkers carbon-11 labeled MMP inhibitors (S)-2-(4′-[ 11C]methoxybiphenyl-4-sulfonylamino)-3-methylbutyric acid and N-hydroxy-(R)-2-[[(4′-[ 11C]methoxyphenyl)sulfonyl]benzylamino]-3-methylbutanamide

(S)-2-(4′-[ 11C]methoxybiphenyl-4-sulfonylamino)-3-methylbutyric acid ([ 11C]MSMA) and N-hydroxy-(R)-2-[[(4′-[ 11C]methoxyphenyl)sulfonyl]benzylamino]-3-methylbutanamide ([ 11C]CGS 25966), carbon-11 labeled matrix metalloproteinase (MMP) inhibitors, have been synthesized for evaluation as new potent...

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Veröffentlicht in:	Nuclear medicine and biology 2004, Vol.31 (1), p.77-85
Hauptverfasser:	Zheng, Qi-Huang, Fei, Xiangshu, Liu, Xuan, Wang, Ji-Quan, Lee Stone, K, Martinez, Tanya D, Gay, Dawn J, Baity, Winston L, Miller, Kathy D, Sledge, George W, Hutchins, Gary D
Format:	Artikel
Sprache:	eng
Schlagworte:	(S)-2-(4′-[ 11C]methoxybiphenyl-4-sulfonylamino)-3-methylbutyric acid Animals Biomarkers, Tumor - metabolism Breast Neoplasms - diagnostic imaging Breast Neoplasms - metabolism Cancer biomarkers Carbon-11 Cell Line, Tumor Hydroxamic Acids - chemistry Hydroxamic Acids - pharmacokinetics Matrix metalloproteinase inhibitor Matrix Metalloproteinase Inhibitors Matrix Metalloproteinases - chemistry Matrix Metalloproteinases - metabolism Mice N-hydroxy-(R)-2-[[(4′-[ 11C]methoxyphenyl)sulfonyl]benzylamino]-3-methylbutanamide Organ Specificity Positron emission tomography Radionuclide Imaging Radiopharmaceuticals - chemistry Radiopharmaceuticals - pharmacokinetics Sulfonamides - chemistry Sulfonamides - pharmacokinetics Tissue Distribution Valine - analogs & derivatives Valine - chemistry Valine - pharmacokinetics
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