CRF and CRF receptors: Role in stress responsivity and other behaviors
Since corticotropin-releasing factor (CRF) was first characterized, a growing family of ligands and receptors has evolved. The mammalian family members include CRF, urocortinI (UcnI), UcnII, and UcnIII, along with two receptors, CRFR1 and CRFR2, and a CRF binding protein. These family members differ...
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| Veröffentlicht in: | Annual review of pharmacology and toxicology 2004-01, Vol.44 (1), p.525-557 |
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| creator | BALER, Tracy L VALE, Wylie W |
| description | Since corticotropin-releasing factor (CRF) was first characterized, a growing family of ligands and receptors has evolved. The mammalian family members include CRF, urocortinI (UcnI), UcnII, and UcnIII, along with two receptors, CRFR1 and CRFR2, and a CRF binding protein. These family members differ in their tissue distribution and pharmacology. Studies have provided evidence supporting an important role of this family in regulation of the endocrine and behavioral responses to stress. Although CRF appears to play a stimulatory role in stress responsivity through activation of CRFR1, specific actions of UcnII and UcnIII on CRFR2 may be important for dampening stress sensitivity. As the only ligand with high affinity for both receptors, UcnI's role may be promiscuous. Regulation of the relative contribution of the two CRF receptors to brain CRF pathways may be essential in coordinating physiological responses to stress. The development of disorders related to heightened stress sensitivity and dysregulation of stress-coping mechanisms appears to involve regulatory mechanisms of CRF family members. |
| doi_str_mv | 10.1146/annurev.pharmtox.44.101802.121410 |
| format | Article |
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The mammalian family members include CRF, urocortinI (UcnI), UcnII, and UcnIII, along with two receptors, CRFR1 and CRFR2, and a CRF binding protein. These family members differ in their tissue distribution and pharmacology. Studies have provided evidence supporting an important role of this family in regulation of the endocrine and behavioral responses to stress. Although CRF appears to play a stimulatory role in stress responsivity through activation of CRFR1, specific actions of UcnII and UcnIII on CRFR2 may be important for dampening stress sensitivity. As the only ligand with high affinity for both receptors, UcnI's role may be promiscuous. Regulation of the relative contribution of the two CRF receptors to brain CRF pathways may be essential in coordinating physiological responses to stress. The development of disorders related to heightened stress sensitivity and dysregulation of stress-coping mechanisms appears to involve regulatory mechanisms of CRF family members.</description><identifier>ISSN: 0362-1642</identifier><identifier>EISSN: 1545-4304</identifier><identifier>DOI: 10.1146/annurev.pharmtox.44.101802.121410</identifier><identifier>PMID: 14744257</identifier><language>eng</language><publisher>Palo Alto, CA: Annual Reviews</publisher><subject>Animals ; Anxiety - genetics ; Anxiety - physiopathology ; Behavior, Animal ; Biological and medical sciences ; Corticotropin-Releasing Hormone - genetics ; Corticotropin-Releasing Hormone - physiology ; Medical sciences ; Mice ; Mice, Knockout ; Mice, Transgenic ; Models, Animal ; Neuropharmacology ; Pharmacology. Drug treatments ; Psycholeptics: tranquillizer, neuroleptic ; Psychology. Psychoanalysis. 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The mammalian family members include CRF, urocortinI (UcnI), UcnII, and UcnIII, along with two receptors, CRFR1 and CRFR2, and a CRF binding protein. These family members differ in their tissue distribution and pharmacology. Studies have provided evidence supporting an important role of this family in regulation of the endocrine and behavioral responses to stress. Although CRF appears to play a stimulatory role in stress responsivity through activation of CRFR1, specific actions of UcnII and UcnIII on CRFR2 may be important for dampening stress sensitivity. As the only ligand with high affinity for both receptors, UcnI's role may be promiscuous. Regulation of the relative contribution of the two CRF receptors to brain CRF pathways may be essential in coordinating physiological responses to stress. The development of disorders related to heightened stress sensitivity and dysregulation of stress-coping mechanisms appears to involve regulatory mechanisms of CRF family members.</description><subject>Animals</subject><subject>Anxiety - genetics</subject><subject>Anxiety - physiopathology</subject><subject>Behavior, Animal</subject><subject>Biological and medical sciences</subject><subject>Corticotropin-Releasing Hormone - genetics</subject><subject>Corticotropin-Releasing Hormone - physiology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Mice, Transgenic</subject><subject>Models, Animal</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psycholeptics: tranquillizer, neuroleptic</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Receptors, Corticotropin-Releasing Hormone - genetics</subject><subject>Receptors, Corticotropin-Releasing Hormone - physiology</subject><subject>Stress, Physiological - genetics</subject><subject>Stress, Physiological - physiopathology</subject><issn>0362-1642</issn><issn>1545-4304</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkcFq3EAMhofQ0GyTvkIxhRZ6sCvNaOxxb2HpNoVAIDTnYeyVWQevx52xl-bt6-06BHLpSQd9-iXxCfEFIUOk_Kvr-ynwIRt2LuxH_ycjyhDQgMxQIiGciRVq0ikpoDdiBSqXKeYkL8S7GB8BoFSEb8UFUkEkdbESm_X9JnH9NjnWwDUPow_xW3LvO07aPolj4BjnThx8H9tDOz79w_2445BUvHOHdh64EueN6yK_X-qleNh8_7W-SW_vfvxcX9-mNRk1poadaraG2Bgua2l4vqhwGvLKVETEquQCVQHQ1BpKloQ5N4SscqpyLgt1KT6fcofgf08cR7tvY81d53r2U7QGUJLK9X9BLEoNRh8TP74CH_0U-vkJK0EbrRWaGbo-QXXwMQZu7BDavQtPFsEe1dhFjX1WY4nsSY09qZkzPiyLpmrP25eExcUMfFoAF2vXNcH1dRtfOK2lggLUX5yFm1Y</recordid><startdate>20040101</startdate><enddate>20040101</enddate><creator>BALER, Tracy L</creator><creator>VALE, Wylie W</creator><general>Annual Reviews</general><general>Annual Reviews, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20040101</creationdate><title>CRF and CRF receptors: Role in stress responsivity and other behaviors</title><author>BALER, Tracy L ; VALE, Wylie W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-8ea3fd84e88e9c28e0097a506b8b444e39e713700fc509e2416ef41e364b6e973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Anxiety - genetics</topic><topic>Anxiety - physiopathology</topic><topic>Behavior, Animal</topic><topic>Biological and medical sciences</topic><topic>Corticotropin-Releasing Hormone - genetics</topic><topic>Corticotropin-Releasing Hormone - physiology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Mice, Transgenic</topic><topic>Models, Animal</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Psycholeptics: tranquillizer, neuroleptic</topic><topic>Psychology. Psychoanalysis. 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| subjects | Animals Anxiety - genetics Anxiety - physiopathology Behavior, Animal Biological and medical sciences Corticotropin-Releasing Hormone - genetics Corticotropin-Releasing Hormone - physiology Medical sciences Mice Mice, Knockout Mice, Transgenic Models, Animal Neuropharmacology Pharmacology. Drug treatments Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Receptors, Corticotropin-Releasing Hormone - genetics Receptors, Corticotropin-Releasing Hormone - physiology Stress, Physiological - genetics Stress, Physiological - physiopathology |
| title | CRF and CRF receptors: Role in stress responsivity and other behaviors |
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