Improved survival of orthotopic liver allograft in swine by addition of trophic factors to university of wisconsin solution
Serum-free preservation media such as University of Wisconsin (UW) may cause tissue damage through trophic factor (TF) deprivation. This study evaluated whether the addition of TFs to UW solution improves liver graft quality after extended cold preservation time in pigs. UW solution was supplemented...
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| Veröffentlicht in: | Transplantation 2004-01, Vol.77 (2), p.302-304 |
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| creator | AMBIRU, Satoshi URYUHARA, Kenji TALPE, Stéphanie DEHOUX, Jean-Paul JACOBBI, Louise MURPHY, Christopher J MCANULTY, Jonathan F GIANELLO, Pierre |
| description | Serum-free preservation media such as University of Wisconsin (UW) may cause tissue damage through trophic factor (TF) deprivation. This study evaluated whether the addition of TFs to UW solution improves liver graft quality after extended cold preservation time in pigs. UW solution was supplemented with epidermal growth factor, insulin-like growth factor-1, nerve growth factor-beta, bactenecin, and substance P to create TF-supplemented (TFS) UW. Orthotopic liver transplantation was performed after 18 hr of static cold storage at 4 degrees C in UW (n=7) or TFS-UW (n=7) solution. Recipients of grafts preserved with TFS-UW demonstrated significantly better 5-day survival (57%) than those preserved with UW alone (14%) (P |
| doi_str_mv | 10.1097/01.TP.0000100468.94126.AF |
| format | Article |
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This study evaluated whether the addition of TFs to UW solution improves liver graft quality after extended cold preservation time in pigs. UW solution was supplemented with epidermal growth factor, insulin-like growth factor-1, nerve growth factor-beta, bactenecin, and substance P to create TF-supplemented (TFS) UW. Orthotopic liver transplantation was performed after 18 hr of static cold storage at 4 degrees C in UW (n=7) or TFS-UW (n=7) solution. Recipients of grafts preserved with TFS-UW demonstrated significantly better 5-day survival (57%) than those preserved with UW alone (14%) (P<0.05). Adenosine triphosphate content in grafts preserved in TFS-UW was significantly higher than in grafts preserved in UW (17.4+/-5.0 vs. 4.8+/-1.2 nmol/mg protein, respectively) (P<0.05). This study showed that the addition of TFs to UW solution allowed a significant extension of cold ischemic time in pigs.</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/01.TP.0000100468.94126.AF</identifier><identifier>PMID: 14742997</identifier><identifier>CODEN: TRPLAU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Adenosine ; Allopurinol ; Animals ; Biological and medical sciences ; Combined surgery. Multiple transplantations ; Epidermal Growth Factor - pharmacology ; Glutathione ; Graft Survival - drug effects ; Graft Survival - physiology ; Growth Substances - pharmacology ; Insulin ; Insulin-Like Growth Factor I - pharmacology ; Liver - drug effects ; Liver Transplantation - physiology ; Medical sciences ; Models, Animal ; Nerve Growth Factor - pharmacology ; Organ Preservation Solutions ; Peptides, Cyclic - pharmacology ; Raffinose ; Substance P - pharmacology ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Swine</subject><ispartof>Transplantation, 2004-01, Vol.77 (2), p.302-304</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-a0a6da59da519830824bc21911fe8469595b7242939950031584d6aec4acc3563</citedby><cites>FETCH-LOGICAL-c425t-a0a6da59da519830824bc21911fe8469595b7242939950031584d6aec4acc3563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15434426$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14742997$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>AMBIRU, Satoshi</creatorcontrib><creatorcontrib>URYUHARA, Kenji</creatorcontrib><creatorcontrib>TALPE, Stéphanie</creatorcontrib><creatorcontrib>DEHOUX, Jean-Paul</creatorcontrib><creatorcontrib>JACOBBI, Louise</creatorcontrib><creatorcontrib>MURPHY, Christopher J</creatorcontrib><creatorcontrib>MCANULTY, Jonathan F</creatorcontrib><creatorcontrib>GIANELLO, Pierre</creatorcontrib><title>Improved survival of orthotopic liver allograft in swine by addition of trophic factors to university of wisconsin solution</title><title>Transplantation</title><addtitle>Transplantation</addtitle><description>Serum-free preservation media such as University of Wisconsin (UW) may cause tissue damage through trophic factor (TF) deprivation. This study evaluated whether the addition of TFs to UW solution improves liver graft quality after extended cold preservation time in pigs. UW solution was supplemented with epidermal growth factor, insulin-like growth factor-1, nerve growth factor-beta, bactenecin, and substance P to create TF-supplemented (TFS) UW. Orthotopic liver transplantation was performed after 18 hr of static cold storage at 4 degrees C in UW (n=7) or TFS-UW (n=7) solution. Recipients of grafts preserved with TFS-UW demonstrated significantly better 5-day survival (57%) than those preserved with UW alone (14%) (P<0.05). Adenosine triphosphate content in grafts preserved in TFS-UW was significantly higher than in grafts preserved in UW (17.4+/-5.0 vs. 4.8+/-1.2 nmol/mg protein, respectively) (P<0.05). This study showed that the addition of TFs to UW solution allowed a significant extension of cold ischemic time in pigs.</description><subject>Adenosine</subject><subject>Allopurinol</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Combined surgery. Multiple transplantations</subject><subject>Epidermal Growth Factor - pharmacology</subject><subject>Glutathione</subject><subject>Graft Survival - drug effects</subject><subject>Graft Survival - physiology</subject><subject>Growth Substances - pharmacology</subject><subject>Insulin</subject><subject>Insulin-Like Growth Factor I - pharmacology</subject><subject>Liver - drug effects</subject><subject>Liver Transplantation - physiology</subject><subject>Medical sciences</subject><subject>Models, Animal</subject><subject>Nerve Growth Factor - pharmacology</subject><subject>Organ Preservation Solutions</subject><subject>Peptides, Cyclic - pharmacology</subject><subject>Raffinose</subject><subject>Substance P - pharmacology</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Swine</subject><issn>0041-1337</issn><issn>1534-6080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1vEzEQhi0EoqHwF5A5wG0Xz_prfYwqQitVoodwthyvlxo562B7U0X8ebxtpByxNPLBzzPj0YvQJyAtECW_Emi3Dy2pBwhhom8Vg060680rtAJOWSNIT16jVX2EBiiVV-hdzr8rz6mUb9EVMMk6peQK_b3bH1I8ugHnOR390QQcRxxTeYwlHrzFwR9dwiaE-CuZsWA_4fzkJ4d3J2yGwRcfp0UpKR4eKz8aW2LKuEQ8T4ubfTktwJPPNk558WOYF-09ejOakN2H832Nfm6-bW9um_sf3-9u1veNZR0vjSFGDIarWqB6SvqO7WwHCmB0PROKK76TXd2HKsUJocB7NgjjLDPWUi7oNfry0rdu-md2ueh9_YsLwUwuzln3BDoGkv8XBKk6TkVfQfUC2hRzTm7Uh-T3Jp00EL1EpAno7YO-RKSfI9LrTXU_nofMu70bLuY5kwp8PgMmWxPGZCbr84XjjDLWCfoP9i2bvA</recordid><startdate>20040127</startdate><enddate>20040127</enddate><creator>AMBIRU, Satoshi</creator><creator>URYUHARA, Kenji</creator><creator>TALPE, Stéphanie</creator><creator>DEHOUX, Jean-Paul</creator><creator>JACOBBI, Louise</creator><creator>MURPHY, Christopher J</creator><creator>MCANULTY, Jonathan F</creator><creator>GIANELLO, Pierre</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20040127</creationdate><title>Improved survival of orthotopic liver allograft in swine by addition of trophic factors to university of wisconsin solution</title><author>AMBIRU, Satoshi ; URYUHARA, Kenji ; TALPE, Stéphanie ; DEHOUX, Jean-Paul ; JACOBBI, Louise ; MURPHY, Christopher J ; MCANULTY, Jonathan F ; GIANELLO, Pierre</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-a0a6da59da519830824bc21911fe8469595b7242939950031584d6aec4acc3563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adenosine</topic><topic>Allopurinol</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Combined surgery. Multiple transplantations</topic><topic>Epidermal Growth Factor - pharmacology</topic><topic>Glutathione</topic><topic>Graft Survival - drug effects</topic><topic>Graft Survival - physiology</topic><topic>Growth Substances - pharmacology</topic><topic>Insulin</topic><topic>Insulin-Like Growth Factor I - pharmacology</topic><topic>Liver - drug effects</topic><topic>Liver Transplantation - physiology</topic><topic>Medical sciences</topic><topic>Models, Animal</topic><topic>Nerve Growth Factor - pharmacology</topic><topic>Organ Preservation Solutions</topic><topic>Peptides, Cyclic - pharmacology</topic><topic>Raffinose</topic><topic>Substance P - pharmacology</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>AMBIRU, Satoshi</creatorcontrib><creatorcontrib>URYUHARA, Kenji</creatorcontrib><creatorcontrib>TALPE, Stéphanie</creatorcontrib><creatorcontrib>DEHOUX, Jean-Paul</creatorcontrib><creatorcontrib>JACOBBI, Louise</creatorcontrib><creatorcontrib>MURPHY, Christopher J</creatorcontrib><creatorcontrib>MCANULTY, Jonathan F</creatorcontrib><creatorcontrib>GIANELLO, Pierre</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>AMBIRU, Satoshi</au><au>URYUHARA, Kenji</au><au>TALPE, Stéphanie</au><au>DEHOUX, Jean-Paul</au><au>JACOBBI, Louise</au><au>MURPHY, Christopher J</au><au>MCANULTY, Jonathan F</au><au>GIANELLO, Pierre</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improved survival of orthotopic liver allograft in swine by addition of trophic factors to university of wisconsin solution</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>2004-01-27</date><risdate>2004</risdate><volume>77</volume><issue>2</issue><spage>302</spage><epage>304</epage><pages>302-304</pages><issn>0041-1337</issn><eissn>1534-6080</eissn><coden>TRPLAU</coden><abstract>Serum-free preservation media such as University of Wisconsin (UW) may cause tissue damage through trophic factor (TF) deprivation. This study evaluated whether the addition of TFs to UW solution improves liver graft quality after extended cold preservation time in pigs. UW solution was supplemented with epidermal growth factor, insulin-like growth factor-1, nerve growth factor-beta, bactenecin, and substance P to create TF-supplemented (TFS) UW. Orthotopic liver transplantation was performed after 18 hr of static cold storage at 4 degrees C in UW (n=7) or TFS-UW (n=7) solution. Recipients of grafts preserved with TFS-UW demonstrated significantly better 5-day survival (57%) than those preserved with UW alone (14%) (P<0.05). Adenosine triphosphate content in grafts preserved in TFS-UW was significantly higher than in grafts preserved in UW (17.4+/-5.0 vs. 4.8+/-1.2 nmol/mg protein, respectively) (P<0.05). This study showed that the addition of TFs to UW solution allowed a significant extension of cold ischemic time in pigs.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>14742997</pmid><doi>10.1097/01.TP.0000100468.94126.AF</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Transplantation, 2004-01, Vol.77 (2), p.302-304 |
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| subjects | Adenosine Allopurinol Animals Biological and medical sciences Combined surgery. Multiple transplantations Epidermal Growth Factor - pharmacology Glutathione Graft Survival - drug effects Graft Survival - physiology Growth Substances - pharmacology Insulin Insulin-Like Growth Factor I - pharmacology Liver - drug effects Liver Transplantation - physiology Medical sciences Models, Animal Nerve Growth Factor - pharmacology Organ Preservation Solutions Peptides, Cyclic - pharmacology Raffinose Substance P - pharmacology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Swine |
| title | Improved survival of orthotopic liver allograft in swine by addition of trophic factors to university of wisconsin solution |
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