Macrophages of Human First Trimester Decidua Express Markers Associated to Alternative Activation
Problem: Depending on the type of their activation, macrophages may promote TH1‐ or TH2‐type of immune responses. To date, not much is known about the activation phenotype of decidua macrophages, which – together with NK cells – constitute the majority of bone marrow derived cells at this location....
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| Veröffentlicht in: | American journal of reproductive immunology (1989) 2004-02, Vol.51 (2), p.117-122 |
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| container_title | American journal of reproductive immunology (1989) |
| container_volume | 51 |
| creator | Cupurdija, Kristijan Azzola, Dagmar Hainz, Ursula Gratchev, Alexei Heitger, Andreas Takikawa, Osamu Goerdt, Sergij Wintersteiger, Reinhold Dohr, Gottfried Sedlmayr, Peter |
| description | Problem: Depending on the type of their activation, macrophages may promote TH1‐ or TH2‐type of immune responses. To date, not much is known about the activation phenotype of decidua macrophages, which – together with NK cells – constitute the majority of bone marrow derived cells at this location.
Method of study: The study was based on analysis of healthy first trimester decidua by immunohistochemistry and flow cytometry. We analyzed expression of markers characteristic for alternatively activated macrophages (Mφ2).
Results: The markers MS‐1 (stabilin‐1) and coagulation factor XIIIa were found expressed in the interior of decidua macrophages (DMφ). In contrast, indoleamine 2,3‐dioxygenase (IDO), an enzyme induced in macrophages by IFNγ, was not present in DMφ.
Conclusions: First trimester DMφ display phenotypic markers associated to alternatively activated macrophages. In addition, absence of IDO indicates that DMφ are not under a predominant influence of IFNγ. |
| doi_str_mv | 10.1046/j.8755-8920.2003.00128.x |
| format | Article |
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Method of study: The study was based on analysis of healthy first trimester decidua by immunohistochemistry and flow cytometry. We analyzed expression of markers characteristic for alternatively activated macrophages (Mφ2).
Results: The markers MS‐1 (stabilin‐1) and coagulation factor XIIIa were found expressed in the interior of decidua macrophages (DMφ). In contrast, indoleamine 2,3‐dioxygenase (IDO), an enzyme induced in macrophages by IFNγ, was not present in DMφ.
Conclusions: First trimester DMφ display phenotypic markers associated to alternatively activated macrophages. In addition, absence of IDO indicates that DMφ are not under a predominant influence of IFNγ.</description><identifier>ISSN: 1046-7408</identifier><identifier>EISSN: 1600-0897</identifier><identifier>DOI: 10.1046/j.8755-8920.2003.00128.x</identifier><identifier>PMID: 14748837</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing</publisher><subject>Biomarkers ; Cell Adhesion Molecules, Neuronal - biosynthesis ; Cell Adhesion Molecules, Neuronal - immunology ; Cell Culture Techniques ; Decidua - immunology ; Decidua - physiology ; Dioxygenases ; Factor VIIIa - biosynthesis ; Factor VIIIa - immunology ; Factor XIIIa ; Female ; Flow Cytometry ; Humans ; Immunohistochemistry ; Immunophenotyping ; Indoleamine-Pyrrole 2,3,-Dioxygenase ; Interferon-gamma - pharmacology ; laser scanning microscopy ; Macrophage Activation - drug effects ; Macrophage Activation - immunology ; Macrophage Activation - physiology ; Macrophage Colony-Stimulating Factor - pharmacology ; Macrophages - immunology ; Macrophages - physiology ; Mφ2 ; Oxygenases - biosynthesis ; Oxygenases - immunology ; placenta ; Pregnancy ; Pregnancy Trimester, First - immunology ; Pregnancy Trimester, First - physiology ; Receptors, Lymphocyte Homing</subject><ispartof>American journal of reproductive immunology (1989), 2004-02, Vol.51 (2), p.117-122</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5018-2e66eef967e4901ecb9eb5fe62a62611413bc6e49e056de21cc064da7e241cc53</citedby><cites>FETCH-LOGICAL-c5018-2e66eef967e4901ecb9eb5fe62a62611413bc6e49e056de21cc064da7e241cc53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.8755-8920.2003.00128.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.8755-8920.2003.00128.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14748837$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cupurdija, Kristijan</creatorcontrib><creatorcontrib>Azzola, Dagmar</creatorcontrib><creatorcontrib>Hainz, Ursula</creatorcontrib><creatorcontrib>Gratchev, Alexei</creatorcontrib><creatorcontrib>Heitger, Andreas</creatorcontrib><creatorcontrib>Takikawa, Osamu</creatorcontrib><creatorcontrib>Goerdt, Sergij</creatorcontrib><creatorcontrib>Wintersteiger, Reinhold</creatorcontrib><creatorcontrib>Dohr, Gottfried</creatorcontrib><creatorcontrib>Sedlmayr, Peter</creatorcontrib><title>Macrophages of Human First Trimester Decidua Express Markers Associated to Alternative Activation</title><title>American journal of reproductive immunology (1989)</title><addtitle>Am J Reprod Immunol</addtitle><description>Problem: Depending on the type of their activation, macrophages may promote TH1‐ or TH2‐type of immune responses. To date, not much is known about the activation phenotype of decidua macrophages, which – together with NK cells – constitute the majority of bone marrow derived cells at this location.
Method of study: The study was based on analysis of healthy first trimester decidua by immunohistochemistry and flow cytometry. We analyzed expression of markers characteristic for alternatively activated macrophages (Mφ2).
Results: The markers MS‐1 (stabilin‐1) and coagulation factor XIIIa were found expressed in the interior of decidua macrophages (DMφ). In contrast, indoleamine 2,3‐dioxygenase (IDO), an enzyme induced in macrophages by IFNγ, was not present in DMφ.
Conclusions: First trimester DMφ display phenotypic markers associated to alternatively activated macrophages. In addition, absence of IDO indicates that DMφ are not under a predominant influence of IFNγ.</description><subject>Biomarkers</subject><subject>Cell Adhesion Molecules, Neuronal - biosynthesis</subject><subject>Cell Adhesion Molecules, Neuronal - immunology</subject><subject>Cell Culture Techniques</subject><subject>Decidua - immunology</subject><subject>Decidua - physiology</subject><subject>Dioxygenases</subject><subject>Factor VIIIa - biosynthesis</subject><subject>Factor VIIIa - immunology</subject><subject>Factor XIIIa</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Immunophenotyping</subject><subject>Indoleamine-Pyrrole 2,3,-Dioxygenase</subject><subject>Interferon-gamma - pharmacology</subject><subject>laser scanning microscopy</subject><subject>Macrophage Activation - drug effects</subject><subject>Macrophage Activation - immunology</subject><subject>Macrophage Activation - physiology</subject><subject>Macrophage Colony-Stimulating Factor - pharmacology</subject><subject>Macrophages - immunology</subject><subject>Macrophages - physiology</subject><subject>Mφ2</subject><subject>Oxygenases - biosynthesis</subject><subject>Oxygenases - immunology</subject><subject>placenta</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, First - immunology</subject><subject>Pregnancy Trimester, First - physiology</subject><subject>Receptors, Lymphocyte Homing</subject><issn>1046-7408</issn><issn>1600-0897</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9v1DAQxa0K1JbCV6h84pYwthPbkbiE0n-ohR6KKnGxvM6kZMluFjuB7bfvbHdFj_Q0T_bvja33GOMCcgGF_jDPrSnLzFYScgmgcgAhbb7eY4dCA2RgK_OKNLGZKcAesDcpzQHoXJl9diAKU1irzCHz1z7EYfXT32PiQ8svpoVf8rMuppHfxm6BacTIP2Pomsnz0_UqYkr82sdfGBOvUxpC50ds-Djwuid26cfuD_I60CA5LN-y163vE77bzSP2_ez09uQiu_p2fnlSX2WhBGEziVojtpU2WFQgMMwqnJUtaum11EIUQs2CpjuEUjcoRQigi8YblAXpUh2x99u9qzj8nujfbtGlgH3vlzhMyVmKSFVS_RcUldSVtZpAuwUpoZQitm5Fifj44AS4TbZu7jY9uE0PbtODe-rBrcl6vHtjmi2weTbugifg4xb42_X48OLFrv5ySYLs2dbeUT_rf3aqxWmjTOnuvp478eNTeSNvtLtTj99upj0</recordid><startdate>200402</startdate><enddate>200402</enddate><creator>Cupurdija, Kristijan</creator><creator>Azzola, Dagmar</creator><creator>Hainz, Ursula</creator><creator>Gratchev, Alexei</creator><creator>Heitger, Andreas</creator><creator>Takikawa, Osamu</creator><creator>Goerdt, Sergij</creator><creator>Wintersteiger, Reinhold</creator><creator>Dohr, Gottfried</creator><creator>Sedlmayr, Peter</creator><general>Blackwell Publishing</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200402</creationdate><title>Macrophages of Human First Trimester Decidua Express Markers Associated to Alternative Activation</title><author>Cupurdija, Kristijan ; Azzola, Dagmar ; Hainz, Ursula ; Gratchev, Alexei ; Heitger, Andreas ; Takikawa, Osamu ; Goerdt, Sergij ; Wintersteiger, Reinhold ; Dohr, Gottfried ; Sedlmayr, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5018-2e66eef967e4901ecb9eb5fe62a62611413bc6e49e056de21cc064da7e241cc53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Biomarkers</topic><topic>Cell Adhesion Molecules, Neuronal - biosynthesis</topic><topic>Cell Adhesion Molecules, Neuronal - immunology</topic><topic>Cell Culture Techniques</topic><topic>Decidua - immunology</topic><topic>Decidua - physiology</topic><topic>Dioxygenases</topic><topic>Factor VIIIa - biosynthesis</topic><topic>Factor VIIIa - immunology</topic><topic>Factor XIIIa</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Immunophenotyping</topic><topic>Indoleamine-Pyrrole 2,3,-Dioxygenase</topic><topic>Interferon-gamma - pharmacology</topic><topic>laser scanning microscopy</topic><topic>Macrophage Activation - drug effects</topic><topic>Macrophage Activation - immunology</topic><topic>Macrophage Activation - physiology</topic><topic>Macrophage Colony-Stimulating Factor - pharmacology</topic><topic>Macrophages - immunology</topic><topic>Macrophages - physiology</topic><topic>Mφ2</topic><topic>Oxygenases - biosynthesis</topic><topic>Oxygenases - immunology</topic><topic>placenta</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, First - immunology</topic><topic>Pregnancy Trimester, First - physiology</topic><topic>Receptors, Lymphocyte Homing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cupurdija, Kristijan</creatorcontrib><creatorcontrib>Azzola, Dagmar</creatorcontrib><creatorcontrib>Hainz, Ursula</creatorcontrib><creatorcontrib>Gratchev, Alexei</creatorcontrib><creatorcontrib>Heitger, Andreas</creatorcontrib><creatorcontrib>Takikawa, Osamu</creatorcontrib><creatorcontrib>Goerdt, Sergij</creatorcontrib><creatorcontrib>Wintersteiger, Reinhold</creatorcontrib><creatorcontrib>Dohr, Gottfried</creatorcontrib><creatorcontrib>Sedlmayr, Peter</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of reproductive immunology (1989)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cupurdija, Kristijan</au><au>Azzola, Dagmar</au><au>Hainz, Ursula</au><au>Gratchev, Alexei</au><au>Heitger, Andreas</au><au>Takikawa, Osamu</au><au>Goerdt, Sergij</au><au>Wintersteiger, Reinhold</au><au>Dohr, Gottfried</au><au>Sedlmayr, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Macrophages of Human First Trimester Decidua Express Markers Associated to Alternative Activation</atitle><jtitle>American journal of reproductive immunology (1989)</jtitle><addtitle>Am J Reprod Immunol</addtitle><date>2004-02</date><risdate>2004</risdate><volume>51</volume><issue>2</issue><spage>117</spage><epage>122</epage><pages>117-122</pages><issn>1046-7408</issn><eissn>1600-0897</eissn><abstract>Problem: Depending on the type of their activation, macrophages may promote TH1‐ or TH2‐type of immune responses. To date, not much is known about the activation phenotype of decidua macrophages, which – together with NK cells – constitute the majority of bone marrow derived cells at this location.
Method of study: The study was based on analysis of healthy first trimester decidua by immunohistochemistry and flow cytometry. We analyzed expression of markers characteristic for alternatively activated macrophages (Mφ2).
Results: The markers MS‐1 (stabilin‐1) and coagulation factor XIIIa were found expressed in the interior of decidua macrophages (DMφ). In contrast, indoleamine 2,3‐dioxygenase (IDO), an enzyme induced in macrophages by IFNγ, was not present in DMφ.
Conclusions: First trimester DMφ display phenotypic markers associated to alternatively activated macrophages. In addition, absence of IDO indicates that DMφ are not under a predominant influence of IFNγ.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing</pub><pmid>14748837</pmid><doi>10.1046/j.8755-8920.2003.00128.x</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1046-7408 |
| ispartof | American journal of reproductive immunology (1989), 2004-02, Vol.51 (2), p.117-122 |
| issn | 1046-7408 1600-0897 |
| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Biomarkers Cell Adhesion Molecules, Neuronal - biosynthesis Cell Adhesion Molecules, Neuronal - immunology Cell Culture Techniques Decidua - immunology Decidua - physiology Dioxygenases Factor VIIIa - biosynthesis Factor VIIIa - immunology Factor XIIIa Female Flow Cytometry Humans Immunohistochemistry Immunophenotyping Indoleamine-Pyrrole 2,3,-Dioxygenase Interferon-gamma - pharmacology laser scanning microscopy Macrophage Activation - drug effects Macrophage Activation - immunology Macrophage Activation - physiology Macrophage Colony-Stimulating Factor - pharmacology Macrophages - immunology Macrophages - physiology Mφ2 Oxygenases - biosynthesis Oxygenases - immunology placenta Pregnancy Pregnancy Trimester, First - immunology Pregnancy Trimester, First - physiology Receptors, Lymphocyte Homing |
| title | Macrophages of Human First Trimester Decidua Express Markers Associated to Alternative Activation |
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