Upper and lower body adipose tissue function: a direct comparison of fat mobilization in humans
Objectives: Fat in the lower body is not associated with the same risk of cardiovascular disease as fat in the upper body. Is this explained by differences in the physiological functioning of the two depots? This study had two objectives: 1) to determine whether fat mobilization and blood flow diffe...
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| Veröffentlicht in: | Obesity (Silver Spring, Md.) Md.), 2004-01, Vol.12 (1), p.114-118 |
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| creator | Tan, G.D Goossens, G.H Humphreys, S.M Vidal, H Karpe, F |
| description | Objectives: Fat in the lower body is not associated with the same risk of cardiovascular disease as fat in the upper body. Is this explained by differences in the physiological functioning of the two depots? This study had two objectives: 1) to determine whether fat mobilization and blood flow differ between gluteal and abdominal adipose tissues in humans, and 2) to develop a new technique to assess gluteal adipose tissue function directly.
Research Methods and Procedures: We performed detailed in vivo studies of adipose tissue function involving the assessment of fat mobilization by measurement of adipose tissue blood flows, arterio‐venous differences of metabolites across each depot, and gene expression in tissue biopsies in a small‐scale physiological study.
Results: Gluteal adipose tissue has a lower blood flow (67% lower, p < 0.05) and lower hormone‐sensitive lipase rate of action (87% lower, p < 0.05) than abdominal adipose tissue. Lipoprotein lipase rate of action and mRNA expression are not different between the depots. This is the first demonstration of a novel technique to directly investigate gluteal adipose tissue metabolism.
Discussion: Direct assessment of fasting adipose tissue metabolism in defined depots show that the buttock is metabolically “silent” in terms of fatty acid release compared with the abdomen. |
| doi_str_mv | 10.1038/oby.2004.15 |
| format | Article |
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Research Methods and Procedures: We performed detailed in vivo studies of adipose tissue function involving the assessment of fat mobilization by measurement of adipose tissue blood flows, arterio‐venous differences of metabolites across each depot, and gene expression in tissue biopsies in a small‐scale physiological study.
Results: Gluteal adipose tissue has a lower blood flow (67% lower, p < 0.05) and lower hormone‐sensitive lipase rate of action (87% lower, p < 0.05) than abdominal adipose tissue. Lipoprotein lipase rate of action and mRNA expression are not different between the depots. This is the first demonstration of a novel technique to directly investigate gluteal adipose tissue metabolism.
Discussion: Direct assessment of fasting adipose tissue metabolism in defined depots show that the buttock is metabolically “silent” in terms of fatty acid release compared with the abdomen.</description><identifier>ISSN: 1071-7323</identifier><identifier>ISSN: 1930-7381</identifier><identifier>EISSN: 1550-8528</identifier><identifier>EISSN: 1930-739X</identifier><identifier>DOI: 10.1038/oby.2004.15</identifier><identifier>PMID: 14742849</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Abdomen ; Adipose Tissue - blood supply ; Adipose Tissue - physiology ; Adult ; Arteries ; Biopsy ; Blood Flow Velocity ; Body Composition ; Body fat ; Body Mass Index ; Buttocks ; Fatty Acids - blood ; free fatty acids ; gene expression ; Humans ; Kinetics ; lipolysis ; Lipoprotein Lipase - genetics ; Lipoprotein Lipase - metabolism ; Male ; regional adipose tissue ; regional blood flow ; RNA, Messenger - analysis ; Sterol Esterase - metabolism ; Triglycerides - blood ; Veins</subject><ispartof>Obesity (Silver Spring, Md.), 2004-01, Vol.12 (1), p.114-118</ispartof><rights>2004 North American Association for the Study of Obesity (NAASO)</rights><rights>Copyright Nature Publishing Group Jan 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4815-a5765d183a157c635e0c5f443d32a49b0327e7871828242821c60b1bd6503efd3</citedby><cites>FETCH-LOGICAL-c4815-a5765d183a157c635e0c5f443d32a49b0327e7871828242821c60b1bd6503efd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1038%2Foby.2004.15$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1038%2Foby.2004.15$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14742849$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tan, G.D</creatorcontrib><creatorcontrib>Goossens, G.H</creatorcontrib><creatorcontrib>Humphreys, S.M</creatorcontrib><creatorcontrib>Vidal, H</creatorcontrib><creatorcontrib>Karpe, F</creatorcontrib><title>Upper and lower body adipose tissue function: a direct comparison of fat mobilization in humans</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obes Res</addtitle><description>Objectives: Fat in the lower body is not associated with the same risk of cardiovascular disease as fat in the upper body. Is this explained by differences in the physiological functioning of the two depots? This study had two objectives: 1) to determine whether fat mobilization and blood flow differ between gluteal and abdominal adipose tissues in humans, and 2) to develop a new technique to assess gluteal adipose tissue function directly.
Research Methods and Procedures: We performed detailed in vivo studies of adipose tissue function involving the assessment of fat mobilization by measurement of adipose tissue blood flows, arterio‐venous differences of metabolites across each depot, and gene expression in tissue biopsies in a small‐scale physiological study.
Results: Gluteal adipose tissue has a lower blood flow (67% lower, p < 0.05) and lower hormone‐sensitive lipase rate of action (87% lower, p < 0.05) than abdominal adipose tissue. Lipoprotein lipase rate of action and mRNA expression are not different between the depots. This is the first demonstration of a novel technique to directly investigate gluteal adipose tissue metabolism.
Discussion: Direct assessment of fasting adipose tissue metabolism in defined depots show that the buttock is metabolically “silent” in terms of fatty acid release compared with the abdomen.</description><subject>Abdomen</subject><subject>Adipose Tissue - blood supply</subject><subject>Adipose Tissue - physiology</subject><subject>Adult</subject><subject>Arteries</subject><subject>Biopsy</subject><subject>Blood Flow Velocity</subject><subject>Body Composition</subject><subject>Body fat</subject><subject>Body Mass Index</subject><subject>Buttocks</subject><subject>Fatty Acids - blood</subject><subject>free fatty acids</subject><subject>gene expression</subject><subject>Humans</subject><subject>Kinetics</subject><subject>lipolysis</subject><subject>Lipoprotein Lipase - genetics</subject><subject>Lipoprotein Lipase - metabolism</subject><subject>Male</subject><subject>regional adipose tissue</subject><subject>regional blood flow</subject><subject>RNA, Messenger - analysis</subject><subject>Sterol Esterase - metabolism</subject><subject>Triglycerides - blood</subject><subject>Veins</subject><issn>1071-7323</issn><issn>1930-7381</issn><issn>1550-8528</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2LFDEQhoMo7jp68q4BwYv0WJWPTmZvuvgFC3vQOXgK6SStWbo7bdLNMv56M8yA4MFTCvLUWy8PIc8Rtghcv03dYcsAxBblA3KJUkKjJdMP6wwKG8UZvyBPSrkDwFZofEwuUCjBtNhdErOf55CpnTwd0n2duuQP1Po4pxLoEktZA-3XyS0xTVfUUh9zcAt1aZxtjiVNNPW0twsdUxeH-NseQRon-nMd7VSekke9HUp4dn43ZP_xw7frz83N7acv1-9uGlcbycZK1UqPmluUyrVcBnCyF4J7zqzYdcCZCkor1EyzWp2ha6HDzrcSeOg935DXp9w5p19rKIsZY3FhGOwU0lqMBmRsV31tyKt_wLu05ql2M_UX6g2OolJvTpTLqZQcejPnONp8qNCR06ZaN0frBmWlX5wz124M_i971lwBOAH3cQiH_2WZ2_ffUbBj5svTSm-TsT-qarP_ygA5IAhQAPwPcviUCA</recordid><startdate>200401</startdate><enddate>200401</enddate><creator>Tan, G.D</creator><creator>Goossens, G.H</creator><creator>Humphreys, S.M</creator><creator>Vidal, H</creator><creator>Karpe, F</creator><general>Blackwell Publishing Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200401</creationdate><title>Upper and lower body adipose tissue function: a direct comparison of fat mobilization in humans</title><author>Tan, G.D ; Goossens, G.H ; Humphreys, S.M ; Vidal, H ; Karpe, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4815-a5765d183a157c635e0c5f443d32a49b0327e7871828242821c60b1bd6503efd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Abdomen</topic><topic>Adipose Tissue - blood supply</topic><topic>Adipose Tissue - physiology</topic><topic>Adult</topic><topic>Arteries</topic><topic>Biopsy</topic><topic>Blood Flow Velocity</topic><topic>Body Composition</topic><topic>Body fat</topic><topic>Body Mass Index</topic><topic>Buttocks</topic><topic>Fatty Acids - blood</topic><topic>free fatty acids</topic><topic>gene expression</topic><topic>Humans</topic><topic>Kinetics</topic><topic>lipolysis</topic><topic>Lipoprotein Lipase - genetics</topic><topic>Lipoprotein Lipase - metabolism</topic><topic>Male</topic><topic>regional adipose tissue</topic><topic>regional blood flow</topic><topic>RNA, Messenger - analysis</topic><topic>Sterol Esterase - metabolism</topic><topic>Triglycerides - blood</topic><topic>Veins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tan, G.D</creatorcontrib><creatorcontrib>Goossens, G.H</creatorcontrib><creatorcontrib>Humphreys, S.M</creatorcontrib><creatorcontrib>Vidal, H</creatorcontrib><creatorcontrib>Karpe, F</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tan, G.D</au><au>Goossens, G.H</au><au>Humphreys, S.M</au><au>Vidal, H</au><au>Karpe, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Upper and lower body adipose tissue function: a direct comparison of fat mobilization in humans</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obes Res</addtitle><date>2004-01</date><risdate>2004</risdate><volume>12</volume><issue>1</issue><spage>114</spage><epage>118</epage><pages>114-118</pages><issn>1071-7323</issn><issn>1930-7381</issn><eissn>1550-8528</eissn><eissn>1930-739X</eissn><abstract>Objectives: Fat in the lower body is not associated with the same risk of cardiovascular disease as fat in the upper body. Is this explained by differences in the physiological functioning of the two depots? This study had two objectives: 1) to determine whether fat mobilization and blood flow differ between gluteal and abdominal adipose tissues in humans, and 2) to develop a new technique to assess gluteal adipose tissue function directly.
Research Methods and Procedures: We performed detailed in vivo studies of adipose tissue function involving the assessment of fat mobilization by measurement of adipose tissue blood flows, arterio‐venous differences of metabolites across each depot, and gene expression in tissue biopsies in a small‐scale physiological study.
Results: Gluteal adipose tissue has a lower blood flow (67% lower, p < 0.05) and lower hormone‐sensitive lipase rate of action (87% lower, p < 0.05) than abdominal adipose tissue. Lipoprotein lipase rate of action and mRNA expression are not different between the depots. This is the first demonstration of a novel technique to directly investigate gluteal adipose tissue metabolism.
Discussion: Direct assessment of fasting adipose tissue metabolism in defined depots show that the buttock is metabolically “silent” in terms of fatty acid release compared with the abdomen.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>14742849</pmid><doi>10.1038/oby.2004.15</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE; Wiley Online Library Free Content; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Abdomen Adipose Tissue - blood supply Adipose Tissue - physiology Adult Arteries Biopsy Blood Flow Velocity Body Composition Body fat Body Mass Index Buttocks Fatty Acids - blood free fatty acids gene expression Humans Kinetics lipolysis Lipoprotein Lipase - genetics Lipoprotein Lipase - metabolism Male regional adipose tissue regional blood flow RNA, Messenger - analysis Sterol Esterase - metabolism Triglycerides - blood Veins |
| title | Upper and lower body adipose tissue function: a direct comparison of fat mobilization in humans |
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