Pharmacokinetics and biodistribution of [ 111In]-avidin and [ 99mTc]-biotin-liposomes injected in the pleural space for the targeting of mediastinal nodes

Pharmacokinetics and mediastinal node uptake of [ 111In]-avidin and [ 99mTc]-biotin-liposomes following either intrapleural (pleural) or intraperitoneal (ip) injection were determined using scintigraphic imaging. Biodistribution results of [ 111In]-avidin at 44 h showed 3.3% uptake in mediastinal no...

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Veröffentlicht in:	Nuclear medicine and biology 2004, Vol.31 (1), p.41-51
Hauptverfasser:	Medina, Luis A, Klipper, Robert, Phillips, William T, Goins, Beth
Format:	Artikel
Sprache:	eng
Schlagworte:	[ 111In]-avidin [ 99mTc]-liposomes Animals Avidin - administration & dosage Avidin - pharmacokinetics Biotin - administration & dosage Biotin - pharmacokinetics Feasibility Studies Indium Radioisotopes - administration & dosage Indium Radioisotopes - pharmacokinetics Injections Liposomes - pharmacokinetics Lymph Nodes - diagnostic imaging Lymph Nodes - metabolism Lymphatics Male Mediastinal nodes Mediastinum - diagnostic imaging Metabolic Clearance Rate Organ Specificity Pharmacokinetics Pleural Cavity - diagnostic imaging Pleural Cavity - metabolism Pleural space Radionuclide Imaging Radiopharmaceuticals - administration & dosage Radiopharmaceuticals - pharmacokinetics Rats Rats, Sprague-Dawley Technetium - administration & dosage Technetium - pharmacokinetics Tissue Distribution
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