G972R IRS-1 variant impairs insulin regulation of endothelial nitric oxide synthase in cultured human endothelial cells

Impaired insulin-mediated vasodilation might contribute to vascular damage in insulin-resistant states. Little is known about insulin regulation of nitric oxide (NO) synthesis in insulin-resistant cells. The aim of this work was to investigate insulin regulation of NO synthesis in human umbilical ve...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2004-01, Vol.109 (3), p.399-405
Hauptverfasser:	FEDERICI, Massimo, PANDOLFI, Assunta, CONSOLI, Agostino, DE FILIPPIS, Elena Anna, PELLEGRINI, Giuliana, MENGHINI, Rossella, LAURO, Davide, CARDELLINI, Marina, ROMANO, Mario, SESTI, Giorgio, LAURO, Renato
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cells, Cultured Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - enzymology Gene Expression Regulation, Enzymologic Humans Insulin - pharmacology Insulin Receptor Substrate Proteins Medical sciences Mitogen-Activated Protein Kinases - metabolism Nitric Oxide Synthase - genetics Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type III Phosphatidylinositol 3-Kinases - metabolism Phosphoproteins - genetics Phosphoproteins - metabolism Phosphorylation - drug effects Polymorphism, Genetic Protein-Serine-Threonine Kinases Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt RNA, Messenger - metabolism Signal Transduction
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