Fluorinated dihydroquinolines as potent n-NOS inhibitors
Fluorinated dihydroquinolines showed reduced basicity of the amidine function. Their syntheses and potencies as neuronal nitric oxide synthase ( n-NOS) inhibitors are reported. Fluorinated dihydroquinolines showed reduced basicity of the amidine function. Their syntheses and potencies as neuronal ni...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2004-02, Vol.14 (3), p.743-746 |
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| container_issue | 3 |
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| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 14 |
| creator | Jaroch, Stefan Rehwinkel, Hartmut Hölscher, Peter Sülzle, Detlev Burton, Gerardine Hillmann, Margrit McDonald, Fiona M. Miklautz, Heribert |
| description | Fluorinated dihydroquinolines showed reduced basicity of the amidine function. Their syntheses and potencies as neuronal nitric oxide synthase (
n-NOS) inhibitors are reported.
Fluorinated dihydroquinolines showed reduced basicity of the amidine function. Their syntheses and potencies as neuronal nitric oxide synthase (
n-NOS) inhibitors are reported. |
| doi_str_mv | 10.1016/j.bmcl.2003.11.022 |
| format | Article |
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n-NOS) inhibitors are reported.
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n-NOS) inhibitors are reported.
Fluorinated dihydroquinolines showed reduced basicity of the amidine function. Their syntheses and potencies as neuronal nitric oxide synthase (
n-NOS) inhibitors are reported.</description><subject>Amidines - metabolism</subject><subject>Biological and medical sciences</subject><subject>Enzyme Inhibitors - chemistry</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Fluorine - chemistry</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Nitric Oxide Synthase - antagonists & inhibitors</subject><subject>Nitric Oxide Synthase Type I</subject><subject>Pharmacology. Drug treatments</subject><subject>Quinolines - chemistry</subject><subject>Quinolines - pharmacology</subject><subject>Structure-Activity Relationship</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAURYMozvjxB1xIN7prfS9N2xTcyOCoILpQwV1Ik1cmQycdk47gv7fDDLhzdTfnXi6HsQuEDAHLm2XWrEyXcYA8Q8yA8wM2RVGKNBdQHLIp1CWkshafE3YS4xIABQhxzCYoKoFc4pTJebfpg_N6IJtYt_ixof_aON93zlNMdEzW_UB-SHz68vqWOL9wjRv6EM_YUau7SOf7PGUf8_v32WP6_PrwNLt7Tk0u-ZCW0hJHbkSTNzVvsTa6aAuZly3Ztq6kkA1y0NJaU5RCkxYGGwuVKDRUFVF-yq53u-vtMYqDWrloqOu0p34TlQTkCEU9gnwHmtDHGKhV6-BWOvwoBLX1pZZq60ttfSlENfoaS5f79U2zIvtX2Qsagas9oKPRXRu0Ny7-cYWoJBRi5G53HI0uvh0FFY0jb8i6QGZQtnf__fgF8r2I2g</recordid><startdate>20040209</startdate><enddate>20040209</enddate><creator>Jaroch, Stefan</creator><creator>Rehwinkel, Hartmut</creator><creator>Hölscher, Peter</creator><creator>Sülzle, Detlev</creator><creator>Burton, Gerardine</creator><creator>Hillmann, Margrit</creator><creator>McDonald, Fiona M.</creator><creator>Miklautz, Heribert</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040209</creationdate><title>Fluorinated dihydroquinolines as potent n-NOS inhibitors</title><author>Jaroch, Stefan ; Rehwinkel, Hartmut ; Hölscher, Peter ; Sülzle, Detlev ; Burton, Gerardine ; Hillmann, Margrit ; McDonald, Fiona M. ; Miklautz, Heribert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-68de212c4b3b92f19ca5f5836fedf97848b120a8ddc564aea4c1bd0745a077ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Amidines - metabolism</topic><topic>Biological and medical sciences</topic><topic>Enzyme Inhibitors - chemistry</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Fluorine - chemistry</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Nitric Oxide Synthase - antagonists & inhibitors</topic><topic>Nitric Oxide Synthase Type I</topic><topic>Pharmacology. Drug treatments</topic><topic>Quinolines - chemistry</topic><topic>Quinolines - pharmacology</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jaroch, Stefan</creatorcontrib><creatorcontrib>Rehwinkel, Hartmut</creatorcontrib><creatorcontrib>Hölscher, Peter</creatorcontrib><creatorcontrib>Sülzle, Detlev</creatorcontrib><creatorcontrib>Burton, Gerardine</creatorcontrib><creatorcontrib>Hillmann, Margrit</creatorcontrib><creatorcontrib>McDonald, Fiona M.</creatorcontrib><creatorcontrib>Miklautz, Heribert</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jaroch, Stefan</au><au>Rehwinkel, Hartmut</au><au>Hölscher, Peter</au><au>Sülzle, Detlev</au><au>Burton, Gerardine</au><au>Hillmann, Margrit</au><au>McDonald, Fiona M.</au><au>Miklautz, Heribert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fluorinated dihydroquinolines as potent n-NOS inhibitors</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2004-02-09</date><risdate>2004</risdate><volume>14</volume><issue>3</issue><spage>743</spage><epage>746</epage><pages>743-746</pages><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>Fluorinated dihydroquinolines showed reduced basicity of the amidine function. Their syntheses and potencies as neuronal nitric oxide synthase (
n-NOS) inhibitors are reported.
Fluorinated dihydroquinolines showed reduced basicity of the amidine function. Their syntheses and potencies as neuronal nitric oxide synthase (
n-NOS) inhibitors are reported.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>14741281</pmid><doi>10.1016/j.bmcl.2003.11.022</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2004-02, Vol.14 (3), p.743-746 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Amidines - metabolism Biological and medical sciences Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Fluorine - chemistry Medical sciences Miscellaneous Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase Type I Pharmacology. Drug treatments Quinolines - chemistry Quinolines - pharmacology Structure-Activity Relationship |
| title | Fluorinated dihydroquinolines as potent n-NOS inhibitors |
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