Fluorinated dihydroquinolines as potent n-NOS inhibitors

Fluorinated dihydroquinolines as potent n-NOS inhibitors

Fluorinated dihydroquinolines showed reduced basicity of the amidine function. Their syntheses and potencies as neuronal nitric oxide synthase ( n-NOS) inhibitors are reported. Fluorinated dihydroquinolines showed reduced basicity of the amidine function. Their syntheses and potencies as neuronal ni...

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 2004-02, Vol.14 (3), p.743-746
Hauptverfasser: Jaroch, Stefan, Rehwinkel, Hartmut, Hölscher, Peter, Sülzle, Detlev, Burton, Gerardine, Hillmann, Margrit, McDonald, Fiona M., Miklautz, Heribert
Format: Artikel
Sprache:eng
Schlagworte:
Amidines - metabolism
Biological and medical sciences
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - pharmacology
Fluorine - chemistry
Medical sciences
Miscellaneous
Nitric Oxide Synthase - antagonists & inhibitors
Nitric Oxide Synthase Type I
Pharmacology. Drug treatments
Quinolines - chemistry
Quinolines - pharmacology
Structure-Activity Relationship
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Zusammenfassung:Fluorinated dihydroquinolines showed reduced basicity of the amidine function. Their syntheses and potencies as neuronal nitric oxide synthase ( n-NOS) inhibitors are reported. Fluorinated dihydroquinolines showed reduced basicity of the amidine function. Their syntheses and potencies as neuronal nitric oxide synthase ( n-NOS) inhibitors are reported.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2003.11.022