Synthesis and Structure-Activity Relationship of Some New β-Blocking Agents with Possible α-Adrenoreceptor Activity
A series of new phenoxypropanolamines with cyclic guanidine and isothiourea moieties has been prepared and investigated for non‐specific α‐ and α‐adrenoreceptor activity by receptor binding experiments on crude rat brain membrane. Some of them [9a, 10c] possess affinity for both β‐ and α‐adrenorecep...
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| Veröffentlicht in: | Archiv der Pharmazie (Weinheim) 1990, Vol.323 (7), p.387-391 |
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| container_title | Archiv der Pharmazie (Weinheim) |
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| creator | Bergmann, JáNos Takács, KáLmáN |
| description | A series of new phenoxypropanolamines with cyclic guanidine and isothiourea moieties has been prepared and investigated for non‐specific α‐ and α‐adrenoreceptor activity by receptor binding experiments on crude rat brain membrane. Some of them [9a, 10c] possess affinity for both β‐ and α‐adrenoreceptors.
Synthese und Zusammenhänge zwischen Struktur und Aktivität von einigen neuen β‐Blockern mit potentieller Aktivität gegenüber α‐Adrenorezeptoren
Einige neue Phenoxypropanolamine mit zyklischen Guanidin‐ und Isothioharnstoff‐Strukturelementen wurden hergestellt und gegenüber unspezifischen β‐ und α‐Adrenorezeptoren durch Rezeptorbindungsexperimente an Rattenhirn‐Membran Präparaten geprüft. Zwei Derivate [9a, 10c] zeigten Affinität gegenüber beiden Typen von Adrenorezeptoren. |
| doi_str_mv | 10.1002/ardp.19903230703 |
| format | Article |
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Synthese und Zusammenhänge zwischen Struktur und Aktivität von einigen neuen β‐Blockern mit potentieller Aktivität gegenüber α‐Adrenorezeptoren
Einige neue Phenoxypropanolamine mit zyklischen Guanidin‐ und Isothioharnstoff‐Strukturelementen wurden hergestellt und gegenüber unspezifischen β‐ und α‐Adrenorezeptoren durch Rezeptorbindungsexperimente an Rattenhirn‐Membran Präparaten geprüft. Zwei Derivate [9a, 10c] zeigten Affinität gegenüber beiden Typen von Adrenorezeptoren.</description><identifier>ISSN: 0365-6233</identifier><identifier>EISSN: 1521-4184</identifier><identifier>DOI: 10.1002/ardp.19903230703</identifier><identifier>PMID: 1978654</identifier><identifier>CODEN: ARPMAS</identifier><language>eng</language><publisher>Hannover: WILEY-VCH Verlag</publisher><subject>Adrenergic alpha-Antagonists - chemical synthesis ; Adrenergic alpha-Antagonists - pharmacology ; Adrenergic beta-Antagonists - chemical synthesis ; Adrenergic beta-Antagonists - pharmacology ; Animals ; Chemical Phenomena ; Chemistry ; Exact sciences and technology ; Heterocyclic compounds ; Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms ; Imidazoles - chemical synthesis ; Imidazoles - pharmacology ; In Vitro Techniques ; Organic chemistry ; Preparations and properties ; Propanolamines - chemical synthesis ; Propanolamines - pharmacology ; Rats ; Structure-Activity Relationship ; Thiourea - analogs & derivatives</subject><ispartof>Archiv der Pharmazie (Weinheim), 1990, Vol.323 (7), p.387-391</ispartof><rights>Copyright © 1990 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3313-c1d34907e669b1c43c491a734eb752a1e6d5a04c0a32fa3119e201a3d62dd9bd3</citedby><cites>FETCH-LOGICAL-c3313-c1d34907e669b1c43c491a734eb752a1e6d5a04c0a32fa3119e201a3d62dd9bd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fardp.19903230703$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fardp.19903230703$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,4024,27923,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19395926$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1978654$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bergmann, JáNos</creatorcontrib><creatorcontrib>Takács, KáLmáN</creatorcontrib><title>Synthesis and Structure-Activity Relationship of Some New β-Blocking Agents with Possible α-Adrenoreceptor Activity</title><title>Archiv der Pharmazie (Weinheim)</title><addtitle>Arch. Pharm. Pharm. Med. Chem</addtitle><description>A series of new phenoxypropanolamines with cyclic guanidine and isothiourea moieties has been prepared and investigated for non‐specific α‐ and α‐adrenoreceptor activity by receptor binding experiments on crude rat brain membrane. Some of them [9a, 10c] possess affinity for both β‐ and α‐adrenoreceptors.
Synthese und Zusammenhänge zwischen Struktur und Aktivität von einigen neuen β‐Blockern mit potentieller Aktivität gegenüber α‐Adrenorezeptoren
Einige neue Phenoxypropanolamine mit zyklischen Guanidin‐ und Isothioharnstoff‐Strukturelementen wurden hergestellt und gegenüber unspezifischen β‐ und α‐Adrenorezeptoren durch Rezeptorbindungsexperimente an Rattenhirn‐Membran Präparaten geprüft. Zwei Derivate [9a, 10c] zeigten Affinität gegenüber beiden Typen von Adrenorezeptoren.</description><subject>Adrenergic alpha-Antagonists - chemical synthesis</subject><subject>Adrenergic alpha-Antagonists - pharmacology</subject><subject>Adrenergic beta-Antagonists - chemical synthesis</subject><subject>Adrenergic beta-Antagonists - pharmacology</subject><subject>Animals</subject><subject>Chemical Phenomena</subject><subject>Chemistry</subject><subject>Exact sciences and technology</subject><subject>Heterocyclic compounds</subject><subject>Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms</subject><subject>Imidazoles - chemical synthesis</subject><subject>Imidazoles - pharmacology</subject><subject>In Vitro Techniques</subject><subject>Organic chemistry</subject><subject>Preparations and properties</subject><subject>Propanolamines - chemical synthesis</subject><subject>Propanolamines - pharmacology</subject><subject>Rats</subject><subject>Structure-Activity Relationship</subject><subject>Thiourea - analogs & derivatives</subject><issn>0365-6233</issn><issn>1521-4184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFv1DAUhC0EKkvhzgXJF7il2H6Jszlw2BZokVZltSniaDn2S9c0mwTbYdmfBT-kv4lUWaCcOL3DfDNvNIQ85-yEMyZea2_7E14UDASwnMEDMuOZ4EnK5-lDMmMgs0QKgMfkSQhfGGPARHZEjniRz2WWzshQ7tu4weAC1a2lZfSDiYPHZGGi--binq6x0dF1bdi4nnY1Lbst0kvc0dufyWnTmRvXXtPFNbYx0J2LG7rqQnBVg_T2R7KwHtvOo8E-dp7-Dn1KHtW6CfjscI_Jp_fvrs4ukuXH8w9ni2ViADgkhltIC5ajlEXFTQomLbjOIcUqz4TmKG2mWWqYBlFr4LxAwbgGK4W1RWXhmLyacnvffR0wRLV1wWDT6Ba7Iag544JJOR9BNoHGj-091qr3bqv9XnGm7pZWd0ure0uPlheH7KHaov1rmKYd9ZcHXQejm9rr1rhwD4MiK4QcuTcTt3MN7v_7Vy3Wb1f_9kgmvwsRv__xa3-jZA55pj5fnquL9VUJ5WqpBPwC2TCqnw</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>Bergmann, JáNos</creator><creator>Takács, KáLmáN</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><general>Wiley-VCH</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1990</creationdate><title>Synthesis and Structure-Activity Relationship of Some New β-Blocking Agents with Possible α-Adrenoreceptor Activity</title><author>Bergmann, JáNos ; Takács, KáLmáN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3313-c1d34907e669b1c43c491a734eb752a1e6d5a04c0a32fa3119e201a3d62dd9bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adrenergic alpha-Antagonists - chemical synthesis</topic><topic>Adrenergic alpha-Antagonists - pharmacology</topic><topic>Adrenergic beta-Antagonists - chemical synthesis</topic><topic>Adrenergic beta-Antagonists - pharmacology</topic><topic>Animals</topic><topic>Chemical Phenomena</topic><topic>Chemistry</topic><topic>Exact sciences and technology</topic><topic>Heterocyclic compounds</topic><topic>Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms</topic><topic>Imidazoles - chemical synthesis</topic><topic>Imidazoles - pharmacology</topic><topic>In Vitro Techniques</topic><topic>Organic chemistry</topic><topic>Preparations and properties</topic><topic>Propanolamines - chemical synthesis</topic><topic>Propanolamines - pharmacology</topic><topic>Rats</topic><topic>Structure-Activity Relationship</topic><topic>Thiourea - analogs & derivatives</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bergmann, JáNos</creatorcontrib><creatorcontrib>Takács, KáLmáN</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archiv der Pharmazie (Weinheim)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bergmann, JáNos</au><au>Takács, KáLmáN</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and Structure-Activity Relationship of Some New β-Blocking Agents with Possible α-Adrenoreceptor Activity</atitle><jtitle>Archiv der Pharmazie (Weinheim)</jtitle><addtitle>Arch. Pharm. Pharm. Med. Chem</addtitle><date>1990</date><risdate>1990</risdate><volume>323</volume><issue>7</issue><spage>387</spage><epage>391</epage><pages>387-391</pages><issn>0365-6233</issn><eissn>1521-4184</eissn><coden>ARPMAS</coden><abstract>A series of new phenoxypropanolamines with cyclic guanidine and isothiourea moieties has been prepared and investigated for non‐specific α‐ and α‐adrenoreceptor activity by receptor binding experiments on crude rat brain membrane. Some of them [9a, 10c] possess affinity for both β‐ and α‐adrenoreceptors.
Synthese und Zusammenhänge zwischen Struktur und Aktivität von einigen neuen β‐Blockern mit potentieller Aktivität gegenüber α‐Adrenorezeptoren
Einige neue Phenoxypropanolamine mit zyklischen Guanidin‐ und Isothioharnstoff‐Strukturelementen wurden hergestellt und gegenüber unspezifischen β‐ und α‐Adrenorezeptoren durch Rezeptorbindungsexperimente an Rattenhirn‐Membran Präparaten geprüft. Zwei Derivate [9a, 10c] zeigten Affinität gegenüber beiden Typen von Adrenorezeptoren.</abstract><cop>Hannover</cop><pub>WILEY-VCH Verlag</pub><pmid>1978654</pmid><doi>10.1002/ardp.19903230703</doi><tpages>5</tpages></addata></record> |
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| ispartof | Archiv der Pharmazie (Weinheim), 1990, Vol.323 (7), p.387-391 |
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| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adrenergic alpha-Antagonists - chemical synthesis Adrenergic alpha-Antagonists - pharmacology Adrenergic beta-Antagonists - chemical synthesis Adrenergic beta-Antagonists - pharmacology Animals Chemical Phenomena Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms Imidazoles - chemical synthesis Imidazoles - pharmacology In Vitro Techniques Organic chemistry Preparations and properties Propanolamines - chemical synthesis Propanolamines - pharmacology Rats Structure-Activity Relationship Thiourea - analogs & derivatives |
| title | Synthesis and Structure-Activity Relationship of Some New β-Blocking Agents with Possible α-Adrenoreceptor Activity |
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