Chronic vasopeptidase inhibition normalizes diabetic endothelial dysfunction

Type 2 diabetes mellitus is a major cause of vascular morbidity but animal models for this disease have not been adequately characterized. We demonstrate that endothelial dysfunction is present in the Zucker diabetic fatty (ZDF) rat. Vasopeptidase inhibition with AVE7688 (7-[[(2 S)-2-(acetylthio)-1-...

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Veröffentlicht in:	European journal of pharmacology 2004-01, Vol.484 (2), p.361-362
Hauptverfasser:	Schäfer, Stefan, Steioff, Kerstin, Linz, Wolfgang, Bleich, Markus, Busch, Andreas E., Löhn, Matthias
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - enzymology Diabetes. Impaired glucose tolerance Diabetic vasculopathy Endocrine pancreas. Apud cells (diseases) Endocrinopathies Endothelium, Vascular - drug effects Endothelium, Vascular - enzymology Heterocyclic Compounds, 3-Ring - administration & dosage Male Medical sciences Mesenteric Arteries - drug effects Mesenteric Arteries - enzymology Protease Inhibitors - administration & dosage Rats Rats, Zucker Renin-Angiotensin System - drug effects Vasopeptidase inhibition Zucker diabetic fatty rat
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