The Long-Term Effect of Oxandrolone on Hepatic Acute Phase Proteins in Severely Burned Children
BACKGROUND Acute phase protein production is a hallmark of severe burns. We wondered whether anabolic treatment with oxandrolone would affect these proteins. METHODS Thirty-five children with ≥40% total body surface area burns were randomized to receive either placebo or oxandrolone (0.1 mg/kg by mo...
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| Veröffentlicht in: | The journal of trauma 2004-01, Vol.56 (1), p.37-44 |
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| container_title | The journal of trauma |
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| creator | Thomas, Suchmor Wolf, Steven E. Murphy, Kevin D. Chinkes, David L. Herndon, David N. |
| description | BACKGROUND Acute phase protein production is a hallmark of severe burns. We wondered whether anabolic treatment with oxandrolone would affect these proteins.
METHODS Thirty-five children with ≥40% total body surface area burns were randomized to receive either placebo or oxandrolone (0.1 mg/kg by mouth twice daily) from postoperative day 5 to 1 year postburn. Levels of constitutive proteins and acute phase proteins were measured at admission; at discharge; and at 6, 9, and 12 months after burn. Total albumin supplementation and hepatic transaminases were also assessed.
RESULTS Constitutive proteins such as albumin, prealbumin, and retinol-binding protein levels increased (p < 0.05), and acute phase proteins such as α1-acid glycoprotein, C3 complement, α2-macroglobulin, and fibrinogen levels significantly decreased in the oxandrolone group compared with placebo (p < 0.05). Albumin supplementation during the acute hospitalization was reduced in the oxandrolone group. Hepatic transaminases remained within normal levels.
CONCLUSION Treatment with oxandrolone in severe burns significantly increases constitutive protein and reduces acute phase protein levels. |
| doi_str_mv | 10.1097/01.TA.0000108636.63225.63 |
| format | Article |
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METHODS Thirty-five children with ≥40% total body surface area burns were randomized to receive either placebo or oxandrolone (0.1 mg/kg by mouth twice daily) from postoperative day 5 to 1 year postburn. Levels of constitutive proteins and acute phase proteins were measured at admission; at discharge; and at 6, 9, and 12 months after burn. Total albumin supplementation and hepatic transaminases were also assessed.
RESULTS Constitutive proteins such as albumin, prealbumin, and retinol-binding protein levels increased (p < 0.05), and acute phase proteins such as α1-acid glycoprotein, C3 complement, α2-macroglobulin, and fibrinogen levels significantly decreased in the oxandrolone group compared with placebo (p < 0.05). Albumin supplementation during the acute hospitalization was reduced in the oxandrolone group. Hepatic transaminases remained within normal levels.
CONCLUSION Treatment with oxandrolone in severe burns significantly increases constitutive protein and reduces acute phase protein levels.</description><identifier>ISSN: 0022-5282</identifier><identifier>EISSN: 1529-8809</identifier><identifier>DOI: 10.1097/01.TA.0000108636.63225.63</identifier><identifier>PMID: 14749563</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins, Inc</publisher><subject>Acute-Phase Proteins - biosynthesis ; Acute-Phase Proteins - metabolism ; Adolescent ; Anabolic Agents - therapeutic use ; Burn Units ; Burns - blood ; Burns - classification ; Burns - metabolism ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Liver - drug effects ; Liver - enzymology ; Liver - metabolism ; Male ; Oxandrolone - therapeutic use ; Transaminases - metabolism</subject><ispartof>The journal of trauma, 2004-01, Vol.56 (1), p.37-44</ispartof><rights>2004 Lippincott Williams & Wilkins, Inc.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4246-d0c428393c3632e26f3d1184e176af4b376733889da54d70c901218030709b133</citedby><cites>FETCH-LOGICAL-c4246-d0c428393c3632e26f3d1184e176af4b376733889da54d70c901218030709b133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27928,27929</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14749563$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thomas, Suchmor</creatorcontrib><creatorcontrib>Wolf, Steven E.</creatorcontrib><creatorcontrib>Murphy, Kevin D.</creatorcontrib><creatorcontrib>Chinkes, David L.</creatorcontrib><creatorcontrib>Herndon, David N.</creatorcontrib><title>The Long-Term Effect of Oxandrolone on Hepatic Acute Phase Proteins in Severely Burned Children</title><title>The journal of trauma</title><addtitle>J Trauma</addtitle><description>BACKGROUND Acute phase protein production is a hallmark of severe burns. We wondered whether anabolic treatment with oxandrolone would affect these proteins.
METHODS Thirty-five children with ≥40% total body surface area burns were randomized to receive either placebo or oxandrolone (0.1 mg/kg by mouth twice daily) from postoperative day 5 to 1 year postburn. Levels of constitutive proteins and acute phase proteins were measured at admission; at discharge; and at 6, 9, and 12 months after burn. Total albumin supplementation and hepatic transaminases were also assessed.
RESULTS Constitutive proteins such as albumin, prealbumin, and retinol-binding protein levels increased (p < 0.05), and acute phase proteins such as α1-acid glycoprotein, C3 complement, α2-macroglobulin, and fibrinogen levels significantly decreased in the oxandrolone group compared with placebo (p < 0.05). Albumin supplementation during the acute hospitalization was reduced in the oxandrolone group. Hepatic transaminases remained within normal levels.
CONCLUSION Treatment with oxandrolone in severe burns significantly increases constitutive protein and reduces acute phase protein levels.</description><subject>Acute-Phase Proteins - biosynthesis</subject><subject>Acute-Phase Proteins - metabolism</subject><subject>Adolescent</subject><subject>Anabolic Agents - therapeutic use</subject><subject>Burn Units</subject><subject>Burns - blood</subject><subject>Burns - classification</subject><subject>Burns - metabolism</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Liver - drug effects</subject><subject>Liver - enzymology</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Oxandrolone - therapeutic use</subject><subject>Transaminases - metabolism</subject><issn>0022-5282</issn><issn>1529-8809</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE-P0zAQxS0EYkvhKyBz4ZYy_hPHPpZqYZEqLRLhbLnJhARcu9jJLvvt8W4r7RzeSNZv3ngeIR8YbBiY5hOwTbvdQCkGWgm1UYLzuugLsmI1N5XWYF6SFQDnVc01vyJvcv5deCmFfk2umGykqZVYEduOSPcx_KpaTEd6PQzYzTQO9PafC32KPgakMdAbPLl56ui2W2ak30eXi6Y44xQynQL9gXeY0D_Qz0sK2NPdOPk-YXhLXg3OZ3x36Wvy88t1u7up9rdfv-22-6qTXKqqh9K1MKIT5RbkahA9Y1oia5Qb5EE0qhFCa9O7WvYNdAYYZxoENGAOTIg1-Xj2PaX4d8E82-OUO_TeBYxLtrrwAMVkTcwZ7FLMOeFgT2k6uvRgGdjHdC0w227tc7r2Kd2iZfb9ZclyOGL_PHmJswDyDNxHP2PKf_xyj8mO6Pw8PlnWohFV-Yks5gDV45MS_wEhsILt</recordid><startdate>200401</startdate><enddate>200401</enddate><creator>Thomas, Suchmor</creator><creator>Wolf, Steven E.</creator><creator>Murphy, Kevin D.</creator><creator>Chinkes, David L.</creator><creator>Herndon, David N.</creator><general>Lippincott Williams & Wilkins, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200401</creationdate><title>The Long-Term Effect of Oxandrolone on Hepatic Acute Phase Proteins in Severely Burned Children</title><author>Thomas, Suchmor ; Wolf, Steven E. ; Murphy, Kevin D. ; Chinkes, David L. ; Herndon, David N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4246-d0c428393c3632e26f3d1184e176af4b376733889da54d70c901218030709b133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Acute-Phase Proteins - biosynthesis</topic><topic>Acute-Phase Proteins - metabolism</topic><topic>Adolescent</topic><topic>Anabolic Agents - therapeutic use</topic><topic>Burn Units</topic><topic>Burns - blood</topic><topic>Burns - classification</topic><topic>Burns - metabolism</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Liver - drug effects</topic><topic>Liver - enzymology</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Oxandrolone - therapeutic use</topic><topic>Transaminases - metabolism</topic><toplevel>online_resources</toplevel><creatorcontrib>Thomas, Suchmor</creatorcontrib><creatorcontrib>Wolf, Steven E.</creatorcontrib><creatorcontrib>Murphy, Kevin D.</creatorcontrib><creatorcontrib>Chinkes, David L.</creatorcontrib><creatorcontrib>Herndon, David N.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of trauma</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thomas, Suchmor</au><au>Wolf, Steven E.</au><au>Murphy, Kevin D.</au><au>Chinkes, David L.</au><au>Herndon, David N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Long-Term Effect of Oxandrolone on Hepatic Acute Phase Proteins in Severely Burned Children</atitle><jtitle>The journal of trauma</jtitle><addtitle>J Trauma</addtitle><date>2004-01</date><risdate>2004</risdate><volume>56</volume><issue>1</issue><spage>37</spage><epage>44</epage><pages>37-44</pages><issn>0022-5282</issn><eissn>1529-8809</eissn><abstract>BACKGROUND Acute phase protein production is a hallmark of severe burns. We wondered whether anabolic treatment with oxandrolone would affect these proteins.
METHODS Thirty-five children with ≥40% total body surface area burns were randomized to receive either placebo or oxandrolone (0.1 mg/kg by mouth twice daily) from postoperative day 5 to 1 year postburn. Levels of constitutive proteins and acute phase proteins were measured at admission; at discharge; and at 6, 9, and 12 months after burn. Total albumin supplementation and hepatic transaminases were also assessed.
RESULTS Constitutive proteins such as albumin, prealbumin, and retinol-binding protein levels increased (p < 0.05), and acute phase proteins such as α1-acid glycoprotein, C3 complement, α2-macroglobulin, and fibrinogen levels significantly decreased in the oxandrolone group compared with placebo (p < 0.05). Albumin supplementation during the acute hospitalization was reduced in the oxandrolone group. Hepatic transaminases remained within normal levels.
CONCLUSION Treatment with oxandrolone in severe burns significantly increases constitutive protein and reduces acute phase protein levels.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>14749563</pmid><doi>10.1097/01.TA.0000108636.63225.63</doi><tpages>8</tpages></addata></record> |
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| ispartof | The journal of trauma, 2004-01, Vol.56 (1), p.37-44 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Acute-Phase Proteins - biosynthesis Acute-Phase Proteins - metabolism Adolescent Anabolic Agents - therapeutic use Burn Units Burns - blood Burns - classification Burns - metabolism Child Child, Preschool Female Humans Infant Liver - drug effects Liver - enzymology Liver - metabolism Male Oxandrolone - therapeutic use Transaminases - metabolism |
| title | The Long-Term Effect of Oxandrolone on Hepatic Acute Phase Proteins in Severely Burned Children |
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