Periodontitis and Systemic Inflammation: Control of the Local Infection is Associated with a Reduction in Serum Inflammatory Markers
Severe periodontitis is associated with elevated inflammatory markers in otherwise healthy populations. However, the nature of this association has not been determined. Our aim was to assess whether the degree of response to periodontal therapy was associated with changes in serological markers of s...
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| Veröffentlicht in: | Journal of dental research 2004-02, Vol.83 (2), p.156-160 |
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| creator | D’Aiuto, F. Parkar, M. Andreou, G. Suvan, J. Brett, P.M. Ready, D. Tonetti, M.S. |
| description | Severe periodontitis is associated with elevated inflammatory markers in otherwise
healthy populations. However, the nature of this association has not been determined.
Our aim was to assess whether the degree of response to periodontal therapy was
associated with changes in serological markers of systemic inflammation. Ninety-four
systemically healthy subjects with severe generalized periodontitis participated in a
prospective six-month blind intervention trial. Periodontal parameters and
inflammatory markers [C-reactive Protein (CRP) and Interleukin-6 (IL-6)] were
evaluated prior to and 2 and 6 mos after delivery of standard non-surgical
periodontal therapy. Six months after treatment, significant reductions in serum IL-6
(p < 0.001, median decrease 0.2 ng/L, 95% CI 0.1–0.4 ng/L) and CRP (p < 0.0001,
median decrease 0.5 mg/L, 95% CI 0.4–0.7) were observed. Decreases in inflammatory
markers were significant in subjects with above average clinical response to
periodontal therapy after correction for possible confounders. Periodontitis may add
to the systemic inflammatory burden of affected individuals. |
| doi_str_mv | 10.1177/154405910408300214 |
| format | Article |
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healthy populations. However, the nature of this association has not been determined.
Our aim was to assess whether the degree of response to periodontal therapy was
associated with changes in serological markers of systemic inflammation. Ninety-four
systemically healthy subjects with severe generalized periodontitis participated in a
prospective six-month blind intervention trial. Periodontal parameters and
inflammatory markers [C-reactive Protein (CRP) and Interleukin-6 (IL-6)] were
evaluated prior to and 2 and 6 mos after delivery of standard non-surgical
periodontal therapy. Six months after treatment, significant reductions in serum IL-6
(p < 0.001, median decrease 0.2 ng/L, 95% CI 0.1–0.4 ng/L) and CRP (p < 0.0001,
median decrease 0.5 mg/L, 95% CI 0.4–0.7) were observed. Decreases in inflammatory
markers were significant in subjects with above average clinical response to
periodontal therapy after correction for possible confounders. Periodontitis may add
to the systemic inflammatory burden of affected individuals.</description><identifier>ISSN: 0022-0345</identifier><identifier>EISSN: 1544-0591</identifier><identifier>DOI: 10.1177/154405910408300214</identifier><identifier>PMID: 14742655</identifier><identifier>CODEN: JDREAF</identifier><language>eng</language><publisher>United States: SAGE Publications</publisher><subject>Aggregatibacter actinomycetemcomitans - isolation & purification ; Bacteroides - isolation & purification ; Biomarkers - blood ; C-Reactive Protein - analysis ; Confidence Intervals ; Confounding Factors (Epidemiology) ; Dentistry ; Female ; Follow-Up Studies ; Humans ; Inflammation - prevention & control ; Inflammation Mediators - blood ; Interleukin-6 - blood ; Longitudinal Studies ; Male ; Middle Aged ; Periodontal Pocket - microbiology ; Periodontal Pocket - therapy ; Periodontitis - blood ; Periodontitis - microbiology ; Periodontitis - prevention & control ; Pilot Projects ; Porphyromonas gingivalis - isolation & purification ; Prospective Studies ; Single-Blind Method</subject><ispartof>Journal of dental research, 2004-02, Vol.83 (2), p.156-160</ispartof><rights>International and American Associations for Dental Research</rights><rights>Copyright American Association for Dental Research/American Academy of Implant Dentistry Feb 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c395t-87cd489c0085689b0397a5ea3cfff66ee06f37195fdf7c9887380b836e47e433</citedby><cites>FETCH-LOGICAL-c395t-87cd489c0085689b0397a5ea3cfff66ee06f37195fdf7c9887380b836e47e433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/154405910408300214$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/154405910408300214$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14742655$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>D’Aiuto, F.</creatorcontrib><creatorcontrib>Parkar, M.</creatorcontrib><creatorcontrib>Andreou, G.</creatorcontrib><creatorcontrib>Suvan, J.</creatorcontrib><creatorcontrib>Brett, P.M.</creatorcontrib><creatorcontrib>Ready, D.</creatorcontrib><creatorcontrib>Tonetti, M.S.</creatorcontrib><title>Periodontitis and Systemic Inflammation: Control of the Local Infection is Associated with a Reduction in Serum Inflammatory Markers</title><title>Journal of dental research</title><addtitle>J Dent Res</addtitle><description>Severe periodontitis is associated with elevated inflammatory markers in otherwise
healthy populations. However, the nature of this association has not been determined.
Our aim was to assess whether the degree of response to periodontal therapy was
associated with changes in serological markers of systemic inflammation. Ninety-four
systemically healthy subjects with severe generalized periodontitis participated in a
prospective six-month blind intervention trial. Periodontal parameters and
inflammatory markers [C-reactive Protein (CRP) and Interleukin-6 (IL-6)] were
evaluated prior to and 2 and 6 mos after delivery of standard non-surgical
periodontal therapy. Six months after treatment, significant reductions in serum IL-6
(p < 0.001, median decrease 0.2 ng/L, 95% CI 0.1–0.4 ng/L) and CRP (p < 0.0001,
median decrease 0.5 mg/L, 95% CI 0.4–0.7) were observed. Decreases in inflammatory
markers were significant in subjects with above average clinical response to
periodontal therapy after correction for possible confounders. Periodontitis may add
to the systemic inflammatory burden of affected individuals.</description><subject>Aggregatibacter actinomycetemcomitans - isolation & purification</subject><subject>Bacteroides - isolation & purification</subject><subject>Biomarkers - blood</subject><subject>C-Reactive Protein - analysis</subject><subject>Confidence Intervals</subject><subject>Confounding Factors (Epidemiology)</subject><subject>Dentistry</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Inflammation - prevention & control</subject><subject>Inflammation Mediators - blood</subject><subject>Interleukin-6 - blood</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Periodontal Pocket - microbiology</subject><subject>Periodontal Pocket - therapy</subject><subject>Periodontitis - blood</subject><subject>Periodontitis - microbiology</subject><subject>Periodontitis - prevention & control</subject><subject>Pilot Projects</subject><subject>Porphyromonas gingivalis - isolation & purification</subject><subject>Prospective Studies</subject><subject>Single-Blind Method</subject><issn>0022-0345</issn><issn>1544-0591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kVFrFDEUhYModlv9Az5I8MG3sTeTZJL4VhathZUW2_chm7mxqTOTmmSQfe8Pd4ZdWFDo04Vzv3NuyCHkHYNPjCl1zqQQIA0DAZoD1Ey8IKtFrBb1JVnNWl0BF_KEnOb8AMBMrflrcsKEEnUj5Yo83WAKsYtjCSVkaseO3u5ywSE4ejX63g6DLSGOn-l6ZlLsafS03CPdRGf7BUG37Olsvsg5umALdvRPKPfU0h_YTYf1SG8xTcMxNKYd_W7TL0z5DXnlbZ_x7WGekbuvX-7W36rN9eXV-mJTOW5kqbRyndDGAWjZaLMFbpSVaLnz3jcNIjSeK2ak77xyRmvFNWw1b1AoFJyfkY_72McUf0-YSzuE7LDv7Yhxyq0GNn8QNDP44R_wIU5pnJ_W1mBEw4HLGar3kEsx54S-fUxhsGnXMmiXftr_-5lN7w_J03bA7mg5FDID53sg2594PPtM5F-GOpig</recordid><startdate>20040201</startdate><enddate>20040201</enddate><creator>D’Aiuto, F.</creator><creator>Parkar, M.</creator><creator>Andreou, G.</creator><creator>Suvan, J.</creator><creator>Brett, P.M.</creator><creator>Ready, D.</creator><creator>Tonetti, M.S.</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RQ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>20040201</creationdate><title>Periodontitis and Systemic Inflammation: Control of the Local Infection is Associated with a Reduction in Serum Inflammatory Markers</title><author>D’Aiuto, F. ; 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healthy populations. However, the nature of this association has not been determined.
Our aim was to assess whether the degree of response to periodontal therapy was
associated with changes in serological markers of systemic inflammation. Ninety-four
systemically healthy subjects with severe generalized periodontitis participated in a
prospective six-month blind intervention trial. Periodontal parameters and
inflammatory markers [C-reactive Protein (CRP) and Interleukin-6 (IL-6)] were
evaluated prior to and 2 and 6 mos after delivery of standard non-surgical
periodontal therapy. Six months after treatment, significant reductions in serum IL-6
(p < 0.001, median decrease 0.2 ng/L, 95% CI 0.1–0.4 ng/L) and CRP (p < 0.0001,
median decrease 0.5 mg/L, 95% CI 0.4–0.7) were observed. Decreases in inflammatory
markers were significant in subjects with above average clinical response to
periodontal therapy after correction for possible confounders. Periodontitis may add
to the systemic inflammatory burden of affected individuals.</abstract><cop>United States</cop><pub>SAGE Publications</pub><pmid>14742655</pmid><doi>10.1177/154405910408300214</doi><tpages>5</tpages></addata></record> |
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| subjects | Aggregatibacter actinomycetemcomitans - isolation & purification Bacteroides - isolation & purification Biomarkers - blood C-Reactive Protein - analysis Confidence Intervals Confounding Factors (Epidemiology) Dentistry Female Follow-Up Studies Humans Inflammation - prevention & control Inflammation Mediators - blood Interleukin-6 - blood Longitudinal Studies Male Middle Aged Periodontal Pocket - microbiology Periodontal Pocket - therapy Periodontitis - blood Periodontitis - microbiology Periodontitis - prevention & control Pilot Projects Porphyromonas gingivalis - isolation & purification Prospective Studies Single-Blind Method |
| title | Periodontitis and Systemic Inflammation: Control of the Local Infection is Associated with a Reduction in Serum Inflammatory Markers |
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