Interleukin‐1‐induced interleukin‐6 is required for the inhibition of proteoglycan synthesis by interleukin‐1 in human articular cartilage

Cartilage from normal controls, patients with osteoarthritis, and patients with rheumatoid arthritis produced no interleukin‐6 (IL‐6) in culture. However, IL‐1 induced massive production of IL‐6 (up to 135 ng/ml) in cartilage from all 3 sources, in a dose‐dependent manner (in some cases, a peak valu...

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Veröffentlicht in:	Arthritis and rheumatism 1990-11, Vol.33 (11), p.1695-1701
Hauptverfasser:	Nietfeld, J. J., Wilbrink, B., Helle, M., Roy, J. L. A. M. Van, Otter, W. Den, Swaak, A. J. G., Huber‐Bruning, O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Arthritis, Rheumatoid - metabolism Cartilage, Articular - metabolism Child, Preschool Culture Techniques Dose-Response Relationship, Drug Humans Interleukin-1 - pharmacology Interleukin-1 - physiology Interleukin-6 - biosynthesis Interleukin-6 - pharmacology Interleukin-6 - physiology Osteoarthritis - metabolism Proteoglycans - biosynthesis Recombinant Proteins - pharmacology Synovial Fluid - metabolism
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