Metabolic dysfunction and depletion of mitochondria in hearts of septic rats

Our previous studies indicate that hearts from septic rats have decreased work with oxygen wasting. The present studies test if there is energy deficit, changes in cardiac mitochondrial content and caspase activation during sepsis. Anesthetized, male Sprague–Dawley rats received no surgical treatmen...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 2004, Vol.36 (1), p.141-150
Hauptverfasser:	Watts, J.A., Kline, J.A., Thornton, L.R., Grattan, R.M., Brar, S.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagy Caspases Caspases - metabolism Cecal ligation and puncture Energy Metabolism Enzyme Activation Heart - physiopathology Mitochondria, Heart - metabolism Mitochondria, Heart - pathology Mitochondria, Heart - ultrastructure Myocardial efficiency Myocardial work Myocardium - metabolism Myocardium - pathology Polymicrobial sepsis Rats Rats, Sprague-Dawley Sepsis - enzymology Sepsis - metabolism Sepsis - pathology Sepsis - physiopathology Substrate oxidation TNFα
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