Blood-glucose-lowering activity of 2-(3-phenylpropoxyimido)-butyrate (BM 13.677)

A single oral or intraperitoneal application of 2-(3-phenylpropoxyimido)-butyrate (BM 13.677) resulted in a dose-dependent blood-glucose-lowering effect in fasted guinea-pigs. The threshold dose and the ec 50 were estimated as 25 mg/kg and 63 mg/kg, respectively, which is between that of the biguani...

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Veröffentlicht in:	Biochemical pharmacology 1990-10, Vol.40 (8), p.1821-1825
Hauptverfasser:	Kühnle, H.F., Wolff, H.P., Schmidt, F.H., Reiter, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cells, Cultured Fasting General and cellular metabolism. Vitamins Gluconeogenesis - drug effects Guinea Pigs Hypoglycemic Agents - pharmacology Imino Acids - administration & dosage Imino Acids - pharmacology Liver - drug effects Male Medical sciences Metformin - pharmacology Mice Pharmacology. Drug treatments Phenformin - pharmacology Rabbits Rats
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