Nuclear accumulation of globular actin as a cellular senescence marker

We evaluated the nuclear actin accumulation as a new marker of cellular senescence, using human diploid fibroblast (HDF), chondrocyte primary cultures, Mv1Lu epithelial cells, and Huh7 cancer cells. Nuclear accumulation of globular actin (G-actin) and dephosphorylated cofilin was highly significant...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2004-01, Vol.64 (2), p.572-580
Hauptverfasser:	Kwak, In Hae, Kim, Hong Seok, Choi, Ok Ran, Ryu, Min Sook, Lim, In Kyoung
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Depolymerizing Factors Actins - metabolism Antineoplastic agents Biological and medical sciences Cell Nucleus - drug effects Cell Nucleus - physiology Cells, Cultured Cellular Senescence - drug effects Cellular Senescence - physiology Deferoxamine - pharmacology Diploidy Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - physiology Humans Hydrogen Peroxide - pharmacology Hydroxyurea - pharmacology Immunohistochemistry Medical sciences Microfilament Proteins - metabolism Pharmacology. Drug treatments Tumors
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