A randomized trial comparing adjuvant chemotherapy versus surgery alone for completely resected pN2 non-small cell lung cancer (JCOG9304)
The purpose of this study was to evaluate the efficacy of adjuvant chemotherapy with three courses of cisplatin and vindesine, in comparison to observation only, for N2 non-small cell lung cancer that had been completely resected. Patients with pathologically demonstrated mediastinal lymph node meta...
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| Veröffentlicht in: | Lung cancer (Amsterdam, Netherlands) Netherlands), 2004-02, Vol.43 (2), p.167-173 |
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| container_title | Lung cancer (Amsterdam, Netherlands) |
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| creator | Tada, Hirohito Tsuchiya, Ryosuke Ichinose, Yukito Koike, Teruaki Nishizawa, Nobuhiro Nagai, Kanji Kato, Harubumi |
| description | The purpose of this study was to evaluate the efficacy of adjuvant chemotherapy with three courses of cisplatin and vindesine, in comparison to observation only, for N2 non-small cell lung cancer that had been completely resected. Patients with pathologically demonstrated mediastinal lymph node metastasis (N2), who had undergone complete resection, were randomized to observation or adjuvant chemotherapy (cisplatin 80
mg/m
2 on day 1; vindesine 3
mg/m
2 on days 1 and 8: ×3 courses). Cycles started within 6 weeks after complete resection and were repeated every 4 weeks. This trial was terminated before accumulation of the planned numbers for registration because of a slow accrual rate. A total of 119 patients were randomized (59 patients in the adjuvant arm and 60 with surgery alone). The median survival was 36 months for both groups. Postoperative cisplatin with vindesine chemotherapy was not shown to be efficacious in cases of completely resected N2 non-small cell lung cancer in this setting of timing, dose and agents studied. |
| doi_str_mv | 10.1016/j.lungcan.2003.08.028 |
| format | Article |
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mg/m
2 on day 1; vindesine 3
mg/m
2 on days 1 and 8: ×3 courses). Cycles started within 6 weeks after complete resection and were repeated every 4 weeks. This trial was terminated before accumulation of the planned numbers for registration because of a slow accrual rate. A total of 119 patients were randomized (59 patients in the adjuvant arm and 60 with surgery alone). The median survival was 36 months for both groups. Postoperative cisplatin with vindesine chemotherapy was not shown to be efficacious in cases of completely resected N2 non-small cell lung cancer in this setting of timing, dose and agents studied.</description><identifier>ISSN: 0169-5002</identifier><identifier>EISSN: 1872-8332</identifier><identifier>DOI: 10.1016/j.lungcan.2003.08.028</identifier><identifier>PMID: 14739037</identifier><identifier>CODEN: LUCAE5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adjuvant chemotherapy ; Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biological and medical sciences ; Carcinoma, Non-Small-Cell Lung - drug therapy ; Carcinoma, Non-Small-Cell Lung - pathology ; Carcinoma, Non-Small-Cell Lung - surgery ; CDDP ; Chemotherapy, Adjuvant ; Cisplatin - administration & dosage ; Complete resection ; Female ; Humans ; Lung Neoplasms - drug therapy ; Lung Neoplasms - pathology ; Lung Neoplasms - surgery ; Lymphatic Metastasis ; Male ; Medical sciences ; Middle Aged ; N2 disease ; Neoplasm Staging ; Non-small cell lung cancer ; Pneumology ; Treatment Outcome ; Tumors of the respiratory system and mediastinum ; Vindesine ; Vindesine - administration & dosage</subject><ispartof>Lung cancer (Amsterdam, Netherlands), 2004-02, Vol.43 (2), p.167-173</ispartof><rights>2003 Elsevier Ireland Ltd</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-9ba570d04842dbe67453f704260eaa028a533c43be00cd656c80f9564b0eee0c3</citedby><cites>FETCH-LOGICAL-c457t-9ba570d04842dbe67453f704260eaa028a533c43be00cd656c80f9564b0eee0c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.lungcan.2003.08.028$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15474414$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14739037$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tada, Hirohito</creatorcontrib><creatorcontrib>Tsuchiya, Ryosuke</creatorcontrib><creatorcontrib>Ichinose, Yukito</creatorcontrib><creatorcontrib>Koike, Teruaki</creatorcontrib><creatorcontrib>Nishizawa, Nobuhiro</creatorcontrib><creatorcontrib>Nagai, Kanji</creatorcontrib><creatorcontrib>Kato, Harubumi</creatorcontrib><creatorcontrib>Japan Clinical Oncology Group</creatorcontrib><title>A randomized trial comparing adjuvant chemotherapy versus surgery alone for completely resected pN2 non-small cell lung cancer (JCOG9304)</title><title>Lung cancer (Amsterdam, Netherlands)</title><addtitle>Lung Cancer</addtitle><description>The purpose of this study was to evaluate the efficacy of adjuvant chemotherapy with three courses of cisplatin and vindesine, in comparison to observation only, for N2 non-small cell lung cancer that had been completely resected. Patients with pathologically demonstrated mediastinal lymph node metastasis (N2), who had undergone complete resection, were randomized to observation or adjuvant chemotherapy (cisplatin 80
mg/m
2 on day 1; vindesine 3
mg/m
2 on days 1 and 8: ×3 courses). Cycles started within 6 weeks after complete resection and were repeated every 4 weeks. This trial was terminated before accumulation of the planned numbers for registration because of a slow accrual rate. A total of 119 patients were randomized (59 patients in the adjuvant arm and 60 with surgery alone). The median survival was 36 months for both groups. Postoperative cisplatin with vindesine chemotherapy was not shown to be efficacious in cases of completely resected N2 non-small cell lung cancer in this setting of timing, dose and agents studied.</description><subject>Adjuvant chemotherapy</subject><subject>Adult</subject><subject>Aged</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Non-Small-Cell Lung - drug therapy</subject><subject>Carcinoma, Non-Small-Cell Lung - pathology</subject><subject>Carcinoma, Non-Small-Cell Lung - surgery</subject><subject>CDDP</subject><subject>Chemotherapy, Adjuvant</subject><subject>Cisplatin - administration & dosage</subject><subject>Complete resection</subject><subject>Female</subject><subject>Humans</subject><subject>Lung Neoplasms - drug therapy</subject><subject>Lung Neoplasms - pathology</subject><subject>Lung Neoplasms - surgery</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>N2 disease</subject><subject>Neoplasm Staging</subject><subject>Non-small cell lung cancer</subject><subject>Pneumology</subject><subject>Treatment Outcome</subject><subject>Tumors of the respiratory system and mediastinum</subject><subject>Vindesine</subject><subject>Vindesine - administration & dosage</subject><issn>0169-5002</issn><issn>1872-8332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhS0EotPCI4C8AcEi4Tq287OqqhEtoIpuYG059s3UoyQOdjLS8Aa8NR4mUpds7M13zj06h5A3DHIGrPy0z_tl3Bk95gUAz6HOoaifkQ2rqyKrOS-ek03imkwCFBfkMsY9AKsYNC_JBRMVb4BXG_LnhgY9Wj-432jpHJzuqfHDpIMbd1Tb_XLQ40zNIw5-fsSgpyM9YIhLpHEJOwxHqns_Iu18-Cfsccb-SANGNHOynL4XdPRjFgfdJ2tMzyk4TckNBvrh2_bhruEgPr4iLzrdR3y9_lfk5-3nH9sv2f3D3dftzX1mhKzmrGm1rMCCqEVhWywrIXlXgShKQK1TB1pybgRvEcDYUpamhq6RpWgBEcHwK_L-7DsF_2vBOKvBxVMuPaJfoqqBMdGIMoHyDJrgYwzYqSm4QYejYqBOG6i9WjdQpw0U1CrdT7q364GlHdA-qdbSE_BuBXQ0uu_SAMbFJ06KSggmEnd95jDVcXAYVDQOU23WhVSust79J8pfvNGorA</recordid><startdate>20040201</startdate><enddate>20040201</enddate><creator>Tada, Hirohito</creator><creator>Tsuchiya, Ryosuke</creator><creator>Ichinose, Yukito</creator><creator>Koike, Teruaki</creator><creator>Nishizawa, Nobuhiro</creator><creator>Nagai, Kanji</creator><creator>Kato, Harubumi</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040201</creationdate><title>A randomized trial comparing adjuvant chemotherapy versus surgery alone for completely resected pN2 non-small cell lung cancer (JCOG9304)</title><author>Tada, Hirohito ; Tsuchiya, Ryosuke ; Ichinose, Yukito ; Koike, Teruaki ; Nishizawa, Nobuhiro ; Nagai, Kanji ; Kato, Harubumi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-9ba570d04842dbe67453f704260eaa028a533c43be00cd656c80f9564b0eee0c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adjuvant chemotherapy</topic><topic>Adult</topic><topic>Aged</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Non-Small-Cell Lung - drug therapy</topic><topic>Carcinoma, Non-Small-Cell Lung - pathology</topic><topic>Carcinoma, Non-Small-Cell Lung - surgery</topic><topic>CDDP</topic><topic>Chemotherapy, Adjuvant</topic><topic>Cisplatin - administration & dosage</topic><topic>Complete resection</topic><topic>Female</topic><topic>Humans</topic><topic>Lung Neoplasms - drug therapy</topic><topic>Lung Neoplasms - pathology</topic><topic>Lung Neoplasms - surgery</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>N2 disease</topic><topic>Neoplasm Staging</topic><topic>Non-small cell lung cancer</topic><topic>Pneumology</topic><topic>Treatment Outcome</topic><topic>Tumors of the respiratory system and mediastinum</topic><topic>Vindesine</topic><topic>Vindesine - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tada, Hirohito</creatorcontrib><creatorcontrib>Tsuchiya, Ryosuke</creatorcontrib><creatorcontrib>Ichinose, Yukito</creatorcontrib><creatorcontrib>Koike, Teruaki</creatorcontrib><creatorcontrib>Nishizawa, Nobuhiro</creatorcontrib><creatorcontrib>Nagai, Kanji</creatorcontrib><creatorcontrib>Kato, Harubumi</creatorcontrib><creatorcontrib>Japan Clinical Oncology Group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Lung cancer (Amsterdam, Netherlands)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tada, Hirohito</au><au>Tsuchiya, Ryosuke</au><au>Ichinose, Yukito</au><au>Koike, Teruaki</au><au>Nishizawa, Nobuhiro</au><au>Nagai, Kanji</au><au>Kato, Harubumi</au><aucorp>Japan Clinical Oncology Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A randomized trial comparing adjuvant chemotherapy versus surgery alone for completely resected pN2 non-small cell lung cancer (JCOG9304)</atitle><jtitle>Lung cancer (Amsterdam, Netherlands)</jtitle><addtitle>Lung Cancer</addtitle><date>2004-02-01</date><risdate>2004</risdate><volume>43</volume><issue>2</issue><spage>167</spage><epage>173</epage><pages>167-173</pages><issn>0169-5002</issn><eissn>1872-8332</eissn><coden>LUCAE5</coden><abstract>The purpose of this study was to evaluate the efficacy of adjuvant chemotherapy with three courses of cisplatin and vindesine, in comparison to observation only, for N2 non-small cell lung cancer that had been completely resected. Patients with pathologically demonstrated mediastinal lymph node metastasis (N2), who had undergone complete resection, were randomized to observation or adjuvant chemotherapy (cisplatin 80
mg/m
2 on day 1; vindesine 3
mg/m
2 on days 1 and 8: ×3 courses). Cycles started within 6 weeks after complete resection and were repeated every 4 weeks. This trial was terminated before accumulation of the planned numbers for registration because of a slow accrual rate. A total of 119 patients were randomized (59 patients in the adjuvant arm and 60 with surgery alone). The median survival was 36 months for both groups. Postoperative cisplatin with vindesine chemotherapy was not shown to be efficacious in cases of completely resected N2 non-small cell lung cancer in this setting of timing, dose and agents studied.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>14739037</pmid><doi>10.1016/j.lungcan.2003.08.028</doi><tpages>7</tpages></addata></record> |
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| issn | 0169-5002 1872-8332 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Adjuvant chemotherapy Adult Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - surgery CDDP Chemotherapy, Adjuvant Cisplatin - administration & dosage Complete resection Female Humans Lung Neoplasms - drug therapy Lung Neoplasms - pathology Lung Neoplasms - surgery Lymphatic Metastasis Male Medical sciences Middle Aged N2 disease Neoplasm Staging Non-small cell lung cancer Pneumology Treatment Outcome Tumors of the respiratory system and mediastinum Vindesine Vindesine - administration & dosage |
| title | A randomized trial comparing adjuvant chemotherapy versus surgery alone for completely resected pN2 non-small cell lung cancer (JCOG9304) |
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