Systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis

Studies in acute liver failure show correlation between evidence of a systemic inflammatory response syndrome (SIRS) and progression of hepatic encephalopathy (HE). We tested the hypothesis that SIRS mediators, such as nitric oxide and proinflammatory cytokines, may exacerbate the neuropsychological...

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Veröffentlicht in:	Journal of hepatology 2004-02, Vol.40 (2), p.247-254
Hauptverfasser:	Shawcross, Debbie L, Davies, Nathan A, Williams, Roger, Jalan, Rajiv
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - blood Amino-acid solution Aminoacid disorders Ammonia - blood Biological and medical sciences C-Reactive Protein - metabolism Errors of metabolism Female Gastroenterology. Liver. Pancreas. Abdomen Hepatic Encephalopathy - complications Hepatic Encephalopathy - immunology Hepatic Encephalopathy - psychology Humans Hyperammonemia - complications Hyperammonemia - immunology Hyperammonemia - psychology Inflammation - complications Inflammation - immunology Inflammation - psychology Inflammation Mediators - metabolism Liver Cirrhosis - complications Liver Cirrhosis - immunology Liver Cirrhosis - psychology Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Mental Recall Metabolic diseases Middle Aged Minimal hepatic encephalopathy Neuropsychological function Neuropsychological Tests Other diseases. Semiology Proinflammatory cytokines Reaction Time
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