Activation of alpha2 adrenergic receptors suppresses fear conditioning: expression of c-Fos and phosphorylated CREB in mouse amygdala

alpha(2) adrenergic agonists such as dexmedetomidine generally suppress noradrenergic transmission and have sedative, analgesic, and antihypertensive properties. Considering the importance of the neurotransmitter norepinephrine in forming memories for fearful events, we have investigated the acute a...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2004-02, Vol.29 (2), p.229-239
Hauptverfasser:	Davies, M Frances, Tsui, Janet, Flannery, Judy A, Li, Xiangqi, DeLorey, Timothy M, Hoffman, Brian B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-2 Receptor Antagonists Amygdala - drug effects Amygdala - metabolism Analysis of Variance Animals Avoidance Learning - drug effects Behavior, Animal Conditioning, Classical - drug effects Conditioning, Classical - physiology Cues Cyclic AMP Response Element-Binding Protein - metabolism Dexmedetomidine - pharmacology Dose-Response Relationship, Drug Fear - physiology Immunohistochemistry - methods Inhibition (Psychology) Male Memory - drug effects Memory - physiology Mice Mice, Inbred Strains Mice, Knockout Phosphorylation Proto-Oncogene Proteins c-fos - metabolism Receptors, Adrenergic, alpha-2 - genetics Receptors, Adrenergic, alpha-2 - metabolism Receptors, Adrenergic, alpha-2 - physiology Species Specificity
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