Metabolic remodelling of the failing heart: the cardiac burn-out syndrome?

It has been postulated that the failing heart suffers from chronic energy starvation, and that derangements in cardiac energy conversion are accessory to the progressive nature of this disease. The molecular mechanisms driving this ‘metabolic remodelling’ process and their significance for the devel...

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Veröffentlicht in:	Cardiovascular research 2004-02, Vol.61 (2), p.218-226
Hauptverfasser:	van Bilsen, Marc, Smeets, Pascal J.H, Gilde, Andries J, van der Vusse, Ger J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Burns Cardiac failure Cardiology. Vascular system Cardiomegaly - metabolism DNA Damage Energy Metabolism Fatty Acids - metabolism Glucose - metabolism Heart Heart Failure - genetics Heart Failure - metabolism Heart failure, cardiogenic pulmonary edema, cardiac enlargement High-energy phosphates Humans Hypertrophy Hypoxia-inducible factor Medical sciences Metabolism Mitochondria Mitochondria, Heart - metabolism Myocardium - metabolism Peroxisome proliferator-activated receptor Phosphates - metabolism Traumas. Diseases due to physical agents
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