Sudden death in young competitive athletes: clinicopathologic correlations in 22 cases
purpose: To investigate the pathologic substrates of sudden death in young competitive athletes. patients and methods: Twenty-two cases of sudden death in young competitive athletes occurring in the Veneto region (northern Italy) in the period January 1979 to December 1989 were studied by postmortem...
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| Veröffentlicht in: | The American journal of medicine 1990-11, Vol.89 (5), p.588-596 |
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| container_title | The American journal of medicine |
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| creator | Corrado, Domenico Thiene, Gaetano Nava, Andrea Rossi, Lino Pennelli, Natale |
| description | purpose: To investigate the pathologic substrates of sudden death in young competitive athletes.
patients and methods: Twenty-two cases of sudden death in young competitive athletes occurring in the Veneto region (northern Italy) in the period January 1979 to December 1989 were studied by postmortem examination. The athletes included 19 males and three females, ranging in age from 11 to 35 years (mean, 23 years).
results: In 18 cases, sudden death occurred during (16 cases) or immediately after (two cases) a competitive sport activity. In 10 subjects, sudden death was apparently the first sign of disease. Postmortem examination disclosed that this fatality was due to arrhythmic cardiac arrest in 17 cases; among these, right ventricular cardiomyopathy, also known as “right ventricular dysplasia,” was the most frequently encountered cardiovascular disease (six cases), followed by atherosclerotic coronary artery disease (four cases), conduction system pathology (three cases), anomalous origin of right coronary artery from the wrong aortic sinus (two cases), and mitral valve prolapse (two cases). In two athletes, the abrupt lethal complication was “mechanical” and consisted of pulmonary embolism and rupture of the aorta; in three athletes, death was due to a cerebral cause. All athletes with right ventricular cardiomyopathy died during effort, and most had a history of palpitations and/or syncope. Whenever available, electrocardiographic (ECG) tracings showed inverted T waves in precordial leads and/or left bundle branch block ventricular arrhythmias.
conclusions: Clinicopathologic correlations indicate that in the Veneto region of Italy, right ventricular cardiomyopathy is not so rare among the cardiovascular diseases associated with the risk of arrhythmic cardiac arrest, and seems to account for the majority of cases of sudden death in young athletes; this disorder can be suspected during life on the basis of prodromal symptoms and ECG signs. |
| doi_str_mv | 10.1016/0002-9343(90)90176-E |
| format | Article |
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patients and methods: Twenty-two cases of sudden death in young competitive athletes occurring in the Veneto region (northern Italy) in the period January 1979 to December 1989 were studied by postmortem examination. The athletes included 19 males and three females, ranging in age from 11 to 35 years (mean, 23 years).
results: In 18 cases, sudden death occurred during (16 cases) or immediately after (two cases) a competitive sport activity. In 10 subjects, sudden death was apparently the first sign of disease. Postmortem examination disclosed that this fatality was due to arrhythmic cardiac arrest in 17 cases; among these, right ventricular cardiomyopathy, also known as “right ventricular dysplasia,” was the most frequently encountered cardiovascular disease (six cases), followed by atherosclerotic coronary artery disease (four cases), conduction system pathology (three cases), anomalous origin of right coronary artery from the wrong aortic sinus (two cases), and mitral valve prolapse (two cases). In two athletes, the abrupt lethal complication was “mechanical” and consisted of pulmonary embolism and rupture of the aorta; in three athletes, death was due to a cerebral cause. All athletes with right ventricular cardiomyopathy died during effort, and most had a history of palpitations and/or syncope. Whenever available, electrocardiographic (ECG) tracings showed inverted T waves in precordial leads and/or left bundle branch block ventricular arrhythmias.
conclusions: Clinicopathologic correlations indicate that in the Veneto region of Italy, right ventricular cardiomyopathy is not so rare among the cardiovascular diseases associated with the risk of arrhythmic cardiac arrest, and seems to account for the majority of cases of sudden death in young athletes; this disorder can be suspected during life on the basis of prodromal symptoms and ECG signs.</description><identifier>ISSN: 0002-9343</identifier><identifier>EISSN: 1555-7162</identifier><identifier>DOI: 10.1016/0002-9343(90)90176-E</identifier><identifier>PMID: 2239978</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Arrhythmias, Cardiac - complications ; Arrhythmias, Cardiac - pathology ; Cardiomyopathies - complications ; Cardiomyopathies - pathology ; Child ; Coronary Artery Disease - complications ; Coronary Artery Disease - pathology ; Coronary Vessel Anomalies - complications ; Coronary Vessel Anomalies - pathology ; Death, Sudden - etiology ; Death, Sudden - pathology ; Female ; Heart Diseases - complications ; Heart Diseases - pathology ; Heart Ventricles - pathology ; Humans ; Italy ; Male ; Mitral Valve Prolapse - complications ; Mitral Valve Prolapse - pathology ; Myocardium - pathology ; Sports</subject><ispartof>The American journal of medicine, 1990-11, Vol.89 (5), p.588-596</ispartof><rights>1990</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-6e463e7225537f77c04136b0658e65e784e560e84a2733f8846e6361058d37ef3</citedby><cites>FETCH-LOGICAL-c389t-6e463e7225537f77c04136b0658e65e784e560e84a2733f8846e6361058d37ef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0002-9343(90)90176-E$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2239978$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Corrado, Domenico</creatorcontrib><creatorcontrib>Thiene, Gaetano</creatorcontrib><creatorcontrib>Nava, Andrea</creatorcontrib><creatorcontrib>Rossi, Lino</creatorcontrib><creatorcontrib>Pennelli, Natale</creatorcontrib><title>Sudden death in young competitive athletes: clinicopathologic correlations in 22 cases</title><title>The American journal of medicine</title><addtitle>Am J Med</addtitle><description>purpose: To investigate the pathologic substrates of sudden death in young competitive athletes.
patients and methods: Twenty-two cases of sudden death in young competitive athletes occurring in the Veneto region (northern Italy) in the period January 1979 to December 1989 were studied by postmortem examination. The athletes included 19 males and three females, ranging in age from 11 to 35 years (mean, 23 years).
results: In 18 cases, sudden death occurred during (16 cases) or immediately after (two cases) a competitive sport activity. In 10 subjects, sudden death was apparently the first sign of disease. Postmortem examination disclosed that this fatality was due to arrhythmic cardiac arrest in 17 cases; among these, right ventricular cardiomyopathy, also known as “right ventricular dysplasia,” was the most frequently encountered cardiovascular disease (six cases), followed by atherosclerotic coronary artery disease (four cases), conduction system pathology (three cases), anomalous origin of right coronary artery from the wrong aortic sinus (two cases), and mitral valve prolapse (two cases). In two athletes, the abrupt lethal complication was “mechanical” and consisted of pulmonary embolism and rupture of the aorta; in three athletes, death was due to a cerebral cause. All athletes with right ventricular cardiomyopathy died during effort, and most had a history of palpitations and/or syncope. Whenever available, electrocardiographic (ECG) tracings showed inverted T waves in precordial leads and/or left bundle branch block ventricular arrhythmias.
conclusions: Clinicopathologic correlations indicate that in the Veneto region of Italy, right ventricular cardiomyopathy is not so rare among the cardiovascular diseases associated with the risk of arrhythmic cardiac arrest, and seems to account for the majority of cases of sudden death in young athletes; this disorder can be suspected during life on the basis of prodromal symptoms and ECG signs.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Arrhythmias, Cardiac - complications</subject><subject>Arrhythmias, Cardiac - pathology</subject><subject>Cardiomyopathies - complications</subject><subject>Cardiomyopathies - pathology</subject><subject>Child</subject><subject>Coronary Artery Disease - complications</subject><subject>Coronary Artery Disease - pathology</subject><subject>Coronary Vessel Anomalies - complications</subject><subject>Coronary Vessel Anomalies - pathology</subject><subject>Death, Sudden - etiology</subject><subject>Death, Sudden - pathology</subject><subject>Female</subject><subject>Heart Diseases - complications</subject><subject>Heart Diseases - pathology</subject><subject>Heart Ventricles - pathology</subject><subject>Humans</subject><subject>Italy</subject><subject>Male</subject><subject>Mitral Valve Prolapse - complications</subject><subject>Mitral Valve Prolapse - pathology</subject><subject>Myocardium - pathology</subject><subject>Sports</subject><issn>0002-9343</issn><issn>1555-7162</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtLw0AQxhdRaq3-Bwo5iR6i-8g-4kGQUh9Q8ODjuqSbSV1JsnV3U-h_b2JLj56Gme_7ZpgfQucE3xBMxC3GmKY5y9hVjq9zTKRIZwdoTDjnqSSCHqLx3nKMTkL47lucczFCI0pZnks1Rp9vXVlCm5RQxK_EtsnGde0yMa5ZQbTRriHphRoihLvE1La1xq36iavd0pre5z3URbSuDUOa0sQUAcIpOqqKOsDZrk7Qx-Psffqczl-fXqYP89QwlcdUQCYYSEo5Z7KS0uCMMLHAgisQHKTKgAsMKiuoZKxSKhMgmCCYq5JJqNgEXW73rrz76SBE3dhgoK6LFlwXtMKEUC5ob8y2RuNdCB4qvfK2KfxGE6wHnHpgpQdWOsf6D6ee9bGL3f5u0UC5D-349fr9Vof-ybUFr4Ox0BoorQcTdens_wd-AcFlgw4</recordid><startdate>199011</startdate><enddate>199011</enddate><creator>Corrado, Domenico</creator><creator>Thiene, Gaetano</creator><creator>Nava, Andrea</creator><creator>Rossi, Lino</creator><creator>Pennelli, Natale</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199011</creationdate><title>Sudden death in young competitive athletes: clinicopathologic correlations in 22 cases</title><author>Corrado, Domenico ; Thiene, Gaetano ; Nava, Andrea ; Rossi, Lino ; Pennelli, Natale</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-6e463e7225537f77c04136b0658e65e784e560e84a2733f8846e6361058d37ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Arrhythmias, Cardiac - complications</topic><topic>Arrhythmias, Cardiac - pathology</topic><topic>Cardiomyopathies - complications</topic><topic>Cardiomyopathies - pathology</topic><topic>Child</topic><topic>Coronary Artery Disease - complications</topic><topic>Coronary Artery Disease - pathology</topic><topic>Coronary Vessel Anomalies - complications</topic><topic>Coronary Vessel Anomalies - pathology</topic><topic>Death, Sudden - etiology</topic><topic>Death, Sudden - pathology</topic><topic>Female</topic><topic>Heart Diseases - complications</topic><topic>Heart Diseases - pathology</topic><topic>Heart Ventricles - pathology</topic><topic>Humans</topic><topic>Italy</topic><topic>Male</topic><topic>Mitral Valve Prolapse - complications</topic><topic>Mitral Valve Prolapse - pathology</topic><topic>Myocardium - pathology</topic><topic>Sports</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Corrado, Domenico</creatorcontrib><creatorcontrib>Thiene, Gaetano</creatorcontrib><creatorcontrib>Nava, Andrea</creatorcontrib><creatorcontrib>Rossi, Lino</creatorcontrib><creatorcontrib>Pennelli, Natale</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Corrado, Domenico</au><au>Thiene, Gaetano</au><au>Nava, Andrea</au><au>Rossi, Lino</au><au>Pennelli, Natale</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sudden death in young competitive athletes: clinicopathologic correlations in 22 cases</atitle><jtitle>The American journal of medicine</jtitle><addtitle>Am J Med</addtitle><date>1990-11</date><risdate>1990</risdate><volume>89</volume><issue>5</issue><spage>588</spage><epage>596</epage><pages>588-596</pages><issn>0002-9343</issn><eissn>1555-7162</eissn><abstract>purpose: To investigate the pathologic substrates of sudden death in young competitive athletes.
patients and methods: Twenty-two cases of sudden death in young competitive athletes occurring in the Veneto region (northern Italy) in the period January 1979 to December 1989 were studied by postmortem examination. The athletes included 19 males and three females, ranging in age from 11 to 35 years (mean, 23 years).
results: In 18 cases, sudden death occurred during (16 cases) or immediately after (two cases) a competitive sport activity. In 10 subjects, sudden death was apparently the first sign of disease. Postmortem examination disclosed that this fatality was due to arrhythmic cardiac arrest in 17 cases; among these, right ventricular cardiomyopathy, also known as “right ventricular dysplasia,” was the most frequently encountered cardiovascular disease (six cases), followed by atherosclerotic coronary artery disease (four cases), conduction system pathology (three cases), anomalous origin of right coronary artery from the wrong aortic sinus (two cases), and mitral valve prolapse (two cases). In two athletes, the abrupt lethal complication was “mechanical” and consisted of pulmonary embolism and rupture of the aorta; in three athletes, death was due to a cerebral cause. All athletes with right ventricular cardiomyopathy died during effort, and most had a history of palpitations and/or syncope. Whenever available, electrocardiographic (ECG) tracings showed inverted T waves in precordial leads and/or left bundle branch block ventricular arrhythmias.
conclusions: Clinicopathologic correlations indicate that in the Veneto region of Italy, right ventricular cardiomyopathy is not so rare among the cardiovascular diseases associated with the risk of arrhythmic cardiac arrest, and seems to account for the majority of cases of sudden death in young athletes; this disorder can be suspected during life on the basis of prodromal symptoms and ECG signs.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>2239978</pmid><doi>10.1016/0002-9343(90)90176-E</doi><tpages>9</tpages></addata></record> |
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| subjects | Adolescent Adult Arrhythmias, Cardiac - complications Arrhythmias, Cardiac - pathology Cardiomyopathies - complications Cardiomyopathies - pathology Child Coronary Artery Disease - complications Coronary Artery Disease - pathology Coronary Vessel Anomalies - complications Coronary Vessel Anomalies - pathology Death, Sudden - etiology Death, Sudden - pathology Female Heart Diseases - complications Heart Diseases - pathology Heart Ventricles - pathology Humans Italy Male Mitral Valve Prolapse - complications Mitral Valve Prolapse - pathology Myocardium - pathology Sports |
| title | Sudden death in young competitive athletes: clinicopathologic correlations in 22 cases |
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