Endothelial Function in Obstructive Sleep Apnea and Response to Treatment
Impaired endothelium-dependent vascular relaxation is a prognostic marker of atherosclerosis and cardiovascular disease. We evaluated endothelium-dependent flow-mediated dilation (FMD) and endothelium-independent nitroglycerin (NTG)-induced dilation of the brachial artery with Doppler ultrasound in...
Gespeichert in:
| Veröffentlicht in: | American journal of respiratory and critical care medicine 2004-02, Vol.169 (3), p.348-353 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 353 |
|---|---|
| container_issue | 3 |
| container_start_page | 348 |
| container_title | American journal of respiratory and critical care medicine |
| container_volume | 169 |
| creator | Ip, Mary S. M Tse, Hung-Fat Lam, Bing Tsang, Kenneth W. T Lam, Wah-Kit |
| description | Impaired endothelium-dependent vascular relaxation is a prognostic marker of atherosclerosis and cardiovascular disease. We evaluated endothelium-dependent flow-mediated dilation (FMD) and endothelium-independent nitroglycerin (NTG)-induced dilation of the brachial artery with Doppler ultrasound in 28 men with obstructive sleep apnea (OSA) and 12 men without OSA. Subjects with OSA (apnea-hypopnea index; mean +/- SD, 46.0 +/- 14.5) had lower FMD compared with subjects without OSA (5.3 +/- 1.7% vs. 8.3 +/- 1.0%, p < 0.001), and major determinants of FMD were the apnea-hypopnea index and age. There was no significant difference in NTG-induced dilation. Subjects with OSA were randomized to nasal continuous positive airway pressure (nCPAP) or observation for 4 weeks. Subjects on nCPAP had significant increase in FMD, whereas those on observation had no change (4.4% vs. -0.8%, difference of 5.2%, p < 0.001). Neither group showed significant change in NTG-induced vasodilation. Eight subjects who used nCPAP for over 3 months were reassessed on withdrawing treatment for 1 week. On nCPAP withdrawal, FMD became lower than during treatment (p = 0.02) and were similar to baseline values. Our findings demonstrated that men with moderate/severe OSA have endothelial dysfunction and treatment with nCPAP could reverse the dysfunction; the effect, however, was dependent on ongoing use. |
| doi_str_mv | 10.1164/rccm.200306-767OC |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80112371</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>543398741</sourcerecordid><originalsourceid>FETCH-LOGICAL-c454t-d3e9e026cf0589e2b9bcb4978b5b4d372693c37d8232739ca665d29cb0952bb53</originalsourceid><addsrcrecordid>eNpdkF1rFDEUhoNY7If-AG8kCBa8mJrvTC7L0mqhsKAt9C4kmbPuLJnMmMwo_nuz7kKhV-cceM57Dg9C7ym5olSJLzmE4YoRwolqtNLr1St0RiWXjTCavK490bwRwjydovNSdoRQ1lLyBp1SIWVN0Gfo7iZ147yF2LuIb5cU5n5MuE947cuclzr-BvwjAkz4ekrgsEsd_g5lGlMBPI_4IYObB0jzW3SycbHAu2O9QI-3Nw-rb839-uvd6vq-CUKKuek4GCBMhQ2RrQHmjQ--_tt66UXHNVOGB667lnGmuQlOKdkxEzwxknkv-QW6POROefy1QJnt0JcAMboE41JsSyhlXNMKfnwB7sYlp_qbpcYoopVRFaIHKOSxlAwbO-V-cPmvpcTuJdu9ZHuQbP9LrjsfjsGLH6B73jharcCnI-BKcHGTXQp9eeakoESK_fHPB27b_9z-6TPYMrgYayy1brc_TJWx3HLR8n9Lv5Kr</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>199607696</pqid></control><display><type>article</type><title>Endothelial Function in Obstructive Sleep Apnea and Response to Treatment</title><source>Journals@Ovid Ovid Autoload</source><source>MEDLINE</source><source>American Thoracic Society (ATS) Journals Online</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Ip, Mary S. M ; Tse, Hung-Fat ; Lam, Bing ; Tsang, Kenneth W. T ; Lam, Wah-Kit</creator><creatorcontrib>Ip, Mary S. M ; Tse, Hung-Fat ; Lam, Bing ; Tsang, Kenneth W. T ; Lam, Wah-Kit</creatorcontrib><description>Impaired endothelium-dependent vascular relaxation is a prognostic marker of atherosclerosis and cardiovascular disease. We evaluated endothelium-dependent flow-mediated dilation (FMD) and endothelium-independent nitroglycerin (NTG)-induced dilation of the brachial artery with Doppler ultrasound in 28 men with obstructive sleep apnea (OSA) and 12 men without OSA. Subjects with OSA (apnea-hypopnea index; mean +/- SD, 46.0 +/- 14.5) had lower FMD compared with subjects without OSA (5.3 +/- 1.7% vs. 8.3 +/- 1.0%, p < 0.001), and major determinants of FMD were the apnea-hypopnea index and age. There was no significant difference in NTG-induced dilation. Subjects with OSA were randomized to nasal continuous positive airway pressure (nCPAP) or observation for 4 weeks. Subjects on nCPAP had significant increase in FMD, whereas those on observation had no change (4.4% vs. -0.8%, difference of 5.2%, p < 0.001). Neither group showed significant change in NTG-induced vasodilation. Eight subjects who used nCPAP for over 3 months were reassessed on withdrawing treatment for 1 week. On nCPAP withdrawal, FMD became lower than during treatment (p = 0.02) and were similar to baseline values. Our findings demonstrated that men with moderate/severe OSA have endothelial dysfunction and treatment with nCPAP could reverse the dysfunction; the effect, however, was dependent on ongoing use.</description><identifier>ISSN: 1073-449X</identifier><identifier>EISSN: 1535-4970</identifier><identifier>DOI: 10.1164/rccm.200306-767OC</identifier><identifier>PMID: 14551167</identifier><language>eng</language><publisher>New York, NY: Am Thoracic Soc</publisher><subject>Adult ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Blood Pressure Determination ; Echocardiography, Doppler ; Endothelium, Vascular - physiopathology ; Humans ; Intensive care medicine ; Laryngeal Masks ; Linear Models ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Polysomnography ; Positive-Pressure Respiration ; Probability ; Reference Values ; Sensitivity and Specificity ; Severity of Illness Index ; Sleep Apnea, Obstructive - diagnosis ; Sleep Apnea, Obstructive - therapy ; Treatment Outcome ; Vascular Resistance - physiology ; Vasoconstriction - physiology ; Vasodilation - physiology</subject><ispartof>American journal of respiratory and critical care medicine, 2004-02, Vol.169 (3), p.348-353</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright American Thoracic Society Feb 1, 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-d3e9e026cf0589e2b9bcb4978b5b4d372693c37d8232739ca665d29cb0952bb53</citedby><cites>FETCH-LOGICAL-c454t-d3e9e026cf0589e2b9bcb4978b5b4d372693c37d8232739ca665d29cb0952bb53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4011,4012,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15410546$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14551167$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ip, Mary S. M</creatorcontrib><creatorcontrib>Tse, Hung-Fat</creatorcontrib><creatorcontrib>Lam, Bing</creatorcontrib><creatorcontrib>Tsang, Kenneth W. T</creatorcontrib><creatorcontrib>Lam, Wah-Kit</creatorcontrib><title>Endothelial Function in Obstructive Sleep Apnea and Response to Treatment</title><title>American journal of respiratory and critical care medicine</title><addtitle>Am J Respir Crit Care Med</addtitle><description>Impaired endothelium-dependent vascular relaxation is a prognostic marker of atherosclerosis and cardiovascular disease. We evaluated endothelium-dependent flow-mediated dilation (FMD) and endothelium-independent nitroglycerin (NTG)-induced dilation of the brachial artery with Doppler ultrasound in 28 men with obstructive sleep apnea (OSA) and 12 men without OSA. Subjects with OSA (apnea-hypopnea index; mean +/- SD, 46.0 +/- 14.5) had lower FMD compared with subjects without OSA (5.3 +/- 1.7% vs. 8.3 +/- 1.0%, p < 0.001), and major determinants of FMD were the apnea-hypopnea index and age. There was no significant difference in NTG-induced dilation. Subjects with OSA were randomized to nasal continuous positive airway pressure (nCPAP) or observation for 4 weeks. Subjects on nCPAP had significant increase in FMD, whereas those on observation had no change (4.4% vs. -0.8%, difference of 5.2%, p < 0.001). Neither group showed significant change in NTG-induced vasodilation. Eight subjects who used nCPAP for over 3 months were reassessed on withdrawing treatment for 1 week. On nCPAP withdrawal, FMD became lower than during treatment (p = 0.02) and were similar to baseline values. Our findings demonstrated that men with moderate/severe OSA have endothelial dysfunction and treatment with nCPAP could reverse the dysfunction; the effect, however, was dependent on ongoing use.</description><subject>Adult</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure Determination</subject><subject>Echocardiography, Doppler</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Laryngeal Masks</subject><subject>Linear Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Polysomnography</subject><subject>Positive-Pressure Respiration</subject><subject>Probability</subject><subject>Reference Values</subject><subject>Sensitivity and Specificity</subject><subject>Severity of Illness Index</subject><subject>Sleep Apnea, Obstructive - diagnosis</subject><subject>Sleep Apnea, Obstructive - therapy</subject><subject>Treatment Outcome</subject><subject>Vascular Resistance - physiology</subject><subject>Vasoconstriction - physiology</subject><subject>Vasodilation - physiology</subject><issn>1073-449X</issn><issn>1535-4970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkF1rFDEUhoNY7If-AG8kCBa8mJrvTC7L0mqhsKAt9C4kmbPuLJnMmMwo_nuz7kKhV-cceM57Dg9C7ym5olSJLzmE4YoRwolqtNLr1St0RiWXjTCavK490bwRwjydovNSdoRQ1lLyBp1SIWVN0Gfo7iZ147yF2LuIb5cU5n5MuE947cuclzr-BvwjAkz4ekrgsEsd_g5lGlMBPI_4IYObB0jzW3SycbHAu2O9QI-3Nw-rb839-uvd6vq-CUKKuek4GCBMhQ2RrQHmjQ--_tt66UXHNVOGB667lnGmuQlOKdkxEzwxknkv-QW6POROefy1QJnt0JcAMboE41JsSyhlXNMKfnwB7sYlp_qbpcYoopVRFaIHKOSxlAwbO-V-cPmvpcTuJdu9ZHuQbP9LrjsfjsGLH6B73jharcCnI-BKcHGTXQp9eeakoESK_fHPB27b_9z-6TPYMrgYayy1brc_TJWx3HLR8n9Lv5Kr</recordid><startdate>20040201</startdate><enddate>20040201</enddate><creator>Ip, Mary S. M</creator><creator>Tse, Hung-Fat</creator><creator>Lam, Bing</creator><creator>Tsang, Kenneth W. T</creator><creator>Lam, Wah-Kit</creator><general>Am Thoracic Soc</general><general>American Lung Association</general><general>American Thoracic Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20040201</creationdate><title>Endothelial Function in Obstructive Sleep Apnea and Response to Treatment</title><author>Ip, Mary S. M ; Tse, Hung-Fat ; Lam, Bing ; Tsang, Kenneth W. T ; Lam, Wah-Kit</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-d3e9e026cf0589e2b9bcb4978b5b4d372693c37d8232739ca665d29cb0952bb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure Determination</topic><topic>Echocardiography, Doppler</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Laryngeal Masks</topic><topic>Linear Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Polysomnography</topic><topic>Positive-Pressure Respiration</topic><topic>Probability</topic><topic>Reference Values</topic><topic>Sensitivity and Specificity</topic><topic>Severity of Illness Index</topic><topic>Sleep Apnea, Obstructive - diagnosis</topic><topic>Sleep Apnea, Obstructive - therapy</topic><topic>Treatment Outcome</topic><topic>Vascular Resistance - physiology</topic><topic>Vasoconstriction - physiology</topic><topic>Vasodilation - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ip, Mary S. M</creatorcontrib><creatorcontrib>Tse, Hung-Fat</creatorcontrib><creatorcontrib>Lam, Bing</creatorcontrib><creatorcontrib>Tsang, Kenneth W. T</creatorcontrib><creatorcontrib>Lam, Wah-Kit</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of respiratory and critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ip, Mary S. M</au><au>Tse, Hung-Fat</au><au>Lam, Bing</au><au>Tsang, Kenneth W. T</au><au>Lam, Wah-Kit</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endothelial Function in Obstructive Sleep Apnea and Response to Treatment</atitle><jtitle>American journal of respiratory and critical care medicine</jtitle><addtitle>Am J Respir Crit Care Med</addtitle><date>2004-02-01</date><risdate>2004</risdate><volume>169</volume><issue>3</issue><spage>348</spage><epage>353</epage><pages>348-353</pages><issn>1073-449X</issn><eissn>1535-4970</eissn><abstract>Impaired endothelium-dependent vascular relaxation is a prognostic marker of atherosclerosis and cardiovascular disease. We evaluated endothelium-dependent flow-mediated dilation (FMD) and endothelium-independent nitroglycerin (NTG)-induced dilation of the brachial artery with Doppler ultrasound in 28 men with obstructive sleep apnea (OSA) and 12 men without OSA. Subjects with OSA (apnea-hypopnea index; mean +/- SD, 46.0 +/- 14.5) had lower FMD compared with subjects without OSA (5.3 +/- 1.7% vs. 8.3 +/- 1.0%, p < 0.001), and major determinants of FMD were the apnea-hypopnea index and age. There was no significant difference in NTG-induced dilation. Subjects with OSA were randomized to nasal continuous positive airway pressure (nCPAP) or observation for 4 weeks. Subjects on nCPAP had significant increase in FMD, whereas those on observation had no change (4.4% vs. -0.8%, difference of 5.2%, p < 0.001). Neither group showed significant change in NTG-induced vasodilation. Eight subjects who used nCPAP for over 3 months were reassessed on withdrawing treatment for 1 week. On nCPAP withdrawal, FMD became lower than during treatment (p = 0.02) and were similar to baseline values. Our findings demonstrated that men with moderate/severe OSA have endothelial dysfunction and treatment with nCPAP could reverse the dysfunction; the effect, however, was dependent on ongoing use.</abstract><cop>New York, NY</cop><pub>Am Thoracic Soc</pub><pmid>14551167</pmid><doi>10.1164/rccm.200306-767OC</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1073-449X |
| ispartof | American journal of respiratory and critical care medicine, 2004-02, Vol.169 (3), p.348-353 |
| issn | 1073-449X 1535-4970 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80112371 |
| source | Journals@Ovid Ovid Autoload; MEDLINE; American Thoracic Society (ATS) Journals Online; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood Pressure Determination Echocardiography, Doppler Endothelium, Vascular - physiopathology Humans Intensive care medicine Laryngeal Masks Linear Models Male Medical sciences Middle Aged Multivariate Analysis Polysomnography Positive-Pressure Respiration Probability Reference Values Sensitivity and Specificity Severity of Illness Index Sleep Apnea, Obstructive - diagnosis Sleep Apnea, Obstructive - therapy Treatment Outcome Vascular Resistance - physiology Vasoconstriction - physiology Vasodilation - physiology |
| title | Endothelial Function in Obstructive Sleep Apnea and Response to Treatment |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-20T20%3A51%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Endothelial%20Function%20in%20Obstructive%20Sleep%20Apnea%20and%20Response%20to%20Treatment&rft.jtitle=American%20journal%20of%20respiratory%20and%20critical%20care%20medicine&rft.au=Ip,%20Mary%20S.%20M&rft.date=2004-02-01&rft.volume=169&rft.issue=3&rft.spage=348&rft.epage=353&rft.pages=348-353&rft.issn=1073-449X&rft.eissn=1535-4970&rft_id=info:doi/10.1164/rccm.200306-767OC&rft_dat=%3Cproquest_cross%3E543398741%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=199607696&rft_id=info:pmid/14551167&rfr_iscdi=true |